CA2462646C - Compositions de meningocoque assorties d'un adjuvant - Google Patents
Compositions de meningocoque assorties d'un adjuvant Download PDFInfo
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- CA2462646C CA2462646C CA2462646A CA2462646A CA2462646C CA 2462646 C CA2462646 C CA 2462646C CA 2462646 A CA2462646 A CA 2462646A CA 2462646 A CA2462646 A CA 2462646A CA 2462646 C CA2462646 C CA 2462646C
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- antigen
- microparticles
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- protein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Biological Depolymerization Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
L'invention concerne une combinaison d'oligonucléotides CpG et de microparticules polymères qui constitue un adjuvant extrêmement efficace pour des antigènes de Neisseria. L'invention concerne donc une composition comprenant (a) un antigène de Neisseria; (b) un oligonucléotide CpG; et (c) une microparticule polymère biodégradable.
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32692901P | 2001-10-03 | 2001-10-03 | |
| US60/326,929 | 2001-10-03 | ||
| PCT/US2002/010869 WO2002080648A2 (fr) | 2001-04-05 | 2002-04-05 | Augmentation de l'immunite des muqueuses a la suite d'un amorçage parenteral |
| USPCT/US02/10869 | 2002-04-05 | ||
| US37354702P | 2002-04-17 | 2002-04-17 | |
| US60/373,547 | 2002-04-17 | ||
| US38067702P | 2002-05-13 | 2002-05-13 | |
| US60/380,677 | 2002-05-13 | ||
| US25443802A | 2002-09-24 | 2002-09-24 | |
| US0230423 | 2002-09-24 | ||
| USPCT/US02/30423 | 2002-09-24 | ||
| US10/254,438 | 2002-09-24 | ||
| US10/265,083 | 2002-10-03 | ||
| PCT/US2002/031726 WO2003028661A2 (fr) | 2001-10-03 | 2002-10-03 | Compositions de meningocoque assorties d'un adjuvant |
| USPCT/US02/31486 | 2002-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2462646A1 CA2462646A1 (fr) | 2003-04-10 |
| CA2462646C true CA2462646C (fr) | 2013-02-12 |
Family
ID=32601151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2462646A Expired - Fee Related CA2462646C (fr) | 2001-10-03 | 2002-10-03 | Compositions de meningocoque assorties d'un adjuvant |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1438323A4 (fr) |
| JP (1) | JP4522699B2 (fr) |
| CN (1) | CN100354297C (fr) |
| AU (1) | AU2002334844B2 (fr) |
| BR (1) | BR0213119A (fr) |
| CA (1) | CA2462646C (fr) |
| NZ (1) | NZ532274A (fr) |
| WO (1) | WO2003028661A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| DE60328481D1 (de) * | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| CN1674933B (zh) * | 2002-08-02 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
| EP2263687B1 (fr) | 2002-12-27 | 2015-03-25 | Novartis Vaccines and Diagnostics, Inc. | Compositions immunogènes contenant des phospholipides |
| CA2514667C (fr) * | 2003-01-30 | 2013-01-08 | Chiron Corporation | Vaccin contre la grippe contenant un adjuvant |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| ES2596553T3 (es) | 2003-06-02 | 2017-01-10 | Glaxosmithkline Biologicals Sa | Composiciones inmunogénicas a base de micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido |
| JP2007523173A (ja) * | 2004-02-20 | 2007-08-16 | イデラ ファーマシューティカルズ インコーポレイテッド | 修飾免疫調節オリゴヌクレオチドにより誘導された強力な粘膜免疫応答 |
| AU2005334819B2 (en) * | 2004-11-15 | 2011-11-24 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
| ZA200707249B (en) | 2005-01-28 | 2010-08-25 | Galen Bio Inc | Immunologically active compositions |
| DE602006008278D1 (de) * | 2005-03-02 | 2009-09-17 | Pharmazeutische zusammensetzung | |
| AU2008335457B2 (en) | 2007-12-07 | 2015-04-16 | Glaxosmithkline Biologicals S.A. | Compositions for inducing immune responses |
| CN101559225B (zh) * | 2008-04-18 | 2012-07-11 | 北京生物制品研究所 | 脑膜炎球菌疫苗 |
| KR102283760B1 (ko) * | 2012-06-21 | 2021-08-03 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| WO2022192937A1 (fr) * | 2021-03-15 | 2022-09-22 | Griffith University | Fractions pathogènes et leurs utilisations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO2000006123A1 (fr) * | 1998-07-29 | 2000-02-10 | Chiron Corporation | Microparticules avec des surfaces adsorbantes, procedes de fabrication de ces dernieres, et utilisation de ces dernieres |
| BR9813930A (pt) * | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| ATE446368T1 (de) * | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| MX343752B (es) * | 1998-05-01 | 2016-11-22 | Novartis Vaccines & Diagnostics Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| BR9914374A (pt) * | 1998-10-09 | 2002-09-17 | Chiron Corp | Sequências genÈmicas de neisseria e métodos para seu uso |
| WO2000050006A2 (fr) * | 1999-02-26 | 2000-08-31 | Chiron Corporation | Microemulsions a macromolecules et microparticules adsorbees |
| AU2457100A (en) * | 1999-02-26 | 2000-09-14 | Chiron S.P.A. | Enhancement of bactericidal activity of neisseria antigens with oligonucleotidescontaining cg motifs |
| NZ571167A (en) * | 1999-04-30 | 2010-05-28 | Novartis Vaccines & Diagnostic | Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents |
| PT2270030E (pt) * | 2000-02-28 | 2012-07-24 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
-
2002
- 2002-10-03 NZ NZ532274A patent/NZ532274A/en not_active IP Right Cessation
- 2002-10-03 BR BR0213119-6A patent/BR0213119A/pt not_active IP Right Cessation
- 2002-10-03 CA CA2462646A patent/CA2462646C/fr not_active Expired - Fee Related
- 2002-10-03 WO PCT/US2002/031726 patent/WO2003028661A2/fr not_active Ceased
- 2002-10-03 EP EP02800481A patent/EP1438323A4/fr not_active Withdrawn
- 2002-10-03 CN CNB028241282A patent/CN100354297C/zh not_active Expired - Fee Related
- 2002-10-03 JP JP2003531997A patent/JP4522699B2/ja not_active Expired - Fee Related
- 2002-10-03 AU AU2002334844A patent/AU2002334844B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005526697A (ja) | 2005-09-08 |
| WO2003028661A2 (fr) | 2003-04-10 |
| AU2002334844B8 (en) | 2003-04-14 |
| BR0213119A (pt) | 2004-12-28 |
| JP4522699B2 (ja) | 2010-08-11 |
| WO2003028661A3 (fr) | 2003-10-09 |
| CN1599746A (zh) | 2005-03-23 |
| EP1438323A2 (fr) | 2004-07-21 |
| AU2002334844B2 (en) | 2007-08-02 |
| CN100354297C (zh) | 2007-12-12 |
| EP1438323A4 (fr) | 2007-08-01 |
| CA2462646A1 (fr) | 2003-04-10 |
| NZ532274A (en) | 2006-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20141003 |