CA2464306A1 - Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation - Google Patents

Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation Download PDF

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Publication number
CA2464306A1
CA2464306A1 CA002464306A CA2464306A CA2464306A1 CA 2464306 A1 CA2464306 A1 CA 2464306A1 CA 002464306 A CA002464306 A CA 002464306A CA 2464306 A CA2464306 A CA 2464306A CA 2464306 A1 CA2464306 A1 CA 2464306A1
Authority
CA
Canada
Prior art keywords
olanzapine
dehydrate
degree
product
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002464306A
Other languages
English (en)
Inventor
Reguri Buchi Reddy
Chakka Ramesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of CA2464306A1 publication Critical patent/CA2464306A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle forme de dihydrate 2-methyl-4-(4-methyl-1-piperazinyl)-10<I>H</I>-thieno[2,3-b][1,5 benzodiazepine (appelé dihydrate-II d'olanzapine), son procédé de préparation et sa conversion en olanzapine de forme II. L'invention concerne également des compositions contenant le dihydrate-II d'olanzapine, l'utilisation dudit dihydrate-II d'olanzapine et des compositions contenant le dihydrate-II d'olanzapine permettant de traiter des troubles du système nerveux central.
CA002464306A 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation Abandoned CA2464306A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN877/MAS/2001 2001-10-29
IN877CH2001 2001-10-29
PCT/US2002/034701 WO2003037903A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Publications (1)

Publication Number Publication Date
CA2464306A1 true CA2464306A1 (fr) 2003-05-08

Family

ID=11097012

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002464306A Abandoned CA2464306A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Country Status (4)

Country Link
EP (1) EP1440074A1 (fr)
AU (1) AU2002340328A1 (fr)
CA (1) CA2464306A1 (fr)
WO (1) WO2003037903A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
AU2003300324A1 (en) 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
ES2289974T1 (es) * 2004-07-14 2008-02-16 Shasun Chemicals And Drugs Limited Metodo mejorado para producir la forma i de la olanzapina.
SI1838716T1 (sl) 2005-01-05 2011-10-28 Lilly Co Eli Olanzapin pamoat dihidrat
CN103185759A (zh) * 2011-12-27 2013-07-03 天津药物研究院 奥氮平中溶剂残留的检测方法及其应用
CN103848847B (zh) * 2012-12-04 2018-02-06 广东东阳光药业有限公司 一种改进制备奥氮平及其晶型ii的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
JP2001500878A (ja) * 1996-09-23 2001-01-23 イーライ・リリー・アンド・カンパニー オランザピン二水和物ｄ
SK2502003A3 (en) * 2000-08-31 2004-03-02 Reddys Lab Ltd Dr Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Also Published As

Publication number Publication date
WO2003037903A1 (fr) 2003-05-08
WO2003037903A8 (fr) 2004-02-12
AU2002340328A1 (en) 2003-05-12
EP1440074A1 (fr) 2004-07-28

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Legal Events

Date Code Title Description
FZDE Discontinued