ATE500258T1 - Verfahren zur herstellung von olanzapin form i - Google Patents

Verfahren zur herstellung von olanzapin form i

Info

Publication number
ATE500258T1
ATE500258T1 AT03736771T AT03736771T ATE500258T1 AT E500258 T1 ATE500258 T1 AT E500258T1 AT 03736771 T AT03736771 T AT 03736771T AT 03736771 T AT03736771 T AT 03736771T AT E500258 T1 ATE500258 T1 AT E500258T1
Authority
AT
Austria
Prior art keywords
olnzapine
producing
methyl
olanzapine
benzodiazepine
Prior art date
Application number
AT03736771T
Other languages
English (en)
Inventor
Hiren V Patel
Anup K Ray
Pramod B Patel
Mahendra R Patel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE500258T1 publication Critical patent/ATE500258T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03736771T 2002-05-31 2003-05-30 Verfahren zur herstellung von olanzapin form i ATE500258T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16095802A 2002-05-31 2002-05-31
PCT/US2003/017186 WO2003101997A1 (en) 2002-05-31 2003-05-30 Process of preparation of olanzapine form i

Publications (1)

Publication Number Publication Date
ATE500258T1 true ATE500258T1 (de) 2011-03-15

Family

ID=29709737

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03736771T ATE500258T1 (de) 2002-05-31 2003-05-30 Verfahren zur herstellung von olanzapin form i

Country Status (7)

Country Link
US (2) US7297789B2 (de)
EP (1) EP1513846B1 (de)
AT (1) ATE500258T1 (de)
AU (1) AU2003237305A1 (de)
DE (1) DE60336226D1 (de)
SI (1) SI1513846T1 (de)
WO (1) WO2003101997A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
AU2003300324A1 (en) * 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
CA2551806A1 (en) * 2003-12-22 2005-07-14 Teva Pharmaceutical Industries, Ltd. Methods of preparing olanzapine
AR047459A1 (es) 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
AR047460A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
EP2264016B1 (de) * 2004-07-14 2013-05-01 Jubilant Organosys Limited Verfahren zur Herstellung einer reinen Form von 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10H-thieno[2,3-B][1,5]-Benzodiazepin
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
WO2006027800A1 (en) 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited A novel process for preparation of a pharmaceutically pure polymorphic form 1 of olanzapine
KR20070113277A (ko) * 2005-03-21 2007-11-28 닥터 레디스 레보러터리즈 리미티드 올란자핀의 결정 형태 ｉ의 제조방법
WO2007020080A1 (en) * 2005-08-17 2007-02-22 Synthon B.V. A process for making olanzapine form i
HUP0501046A2 (en) 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
ES2279715B1 (es) 2005-12-26 2008-06-01 Laboratorios Lesvi, S.L. Formulacion oral de olanzapina.
US7834176B2 (en) * 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
US8106188B2 (en) * 2006-06-01 2012-01-31 Aurobindo Pharma Ltd Process for preparing olanzapine form I
WO2007144901A1 (en) * 2006-06-12 2007-12-21 Jubilant Organosys Limited Process for stabilization of olanzapine polymorphic form i
PL381564A1 (pl) * 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en) * 2007-06-22 2008-12-22 Apotex Pharmachem Inc. Improved processes for the synthesis of olanzapine
EP2292624A1 (de) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Olanzapinreinigungsverfahren
CN102268010A (zh) * 2011-06-17 2011-12-07 大连美罗大药厂 一种奥氮平的制备方法和精制方法
KR101489062B1 (ko) * 2013-03-28 2015-02-02 동아에스티 주식회사 고순도의 올란자핀 및 이의 결정형 ii의 제조방법
CN109456336A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 奥氮平的精制方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH554362A (de) * 1970-07-30 1974-09-30 Spofa Vereinigte Pharma Werke Verfahren zur herstellung von neuen estern tricyklischer piperazinoalkanole.
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5817656A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5817655A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Methods of treatment using a thieno-benzodiazepine
US5627178A (en) * 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5605897A (en) * 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
US5817657A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Psychoactive substance disorders
EG24221A (en) 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
CR5278A (es) 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
JP2001500878A (ja) 1996-09-23 2001-01-23 イーライ・リリー・アンド・カンパニー オランザピン二水和物ｄ
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
DK1155696T3 (da) 1997-04-15 2004-07-12 Lilly Co Eli Anvendelse af olanzapin til fremstillingen af et medikament til neurobeskyttelse
JP2001517684A (ja) 1997-09-30 2001-10-09 イーライ・リリー・アンド・カンパニー 性機能不全を処置するための方法
US7022698B2 (en) * 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
US6348458B1 (en) * 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
DE60019461T2 (de) 1999-12-28 2005-09-22 Cipla Ltd., Bombay Neue polymorphe formen von olanzapin
SK2502003A3 (en) 2000-08-31 2004-03-02 Reddys Lab Ltd Dr Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
US20030097650A1 (en) * 2001-10-04 2003-05-22 International Business Machines Corporation Method and apparatus for testing software
CA2464306A1 (en) 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
JP4530664B2 (ja) 2001-12-24 2010-08-25 サン・ファーマシューティカル・インダストリーズ・リミテッド ２−メチル−４−（４−メチル−１−ピペラジニル）−１０Ｈ−チエノ［２，３−ｂ］［１，５］ベンゾジアゼピンの結晶形Ｉ、この結晶形Ｉの製造方法、及び医薬組成物
PL196814B1 (pl) 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
WO2007020080A1 (en) 2005-08-17 2007-02-22 Synthon B.V. A process for making olanzapine form i

Also Published As

Publication number Publication date
AU2003237305A1 (en) 2003-12-19
EP1513846B1 (de) 2011-03-02
US20080188465A1 (en) 2008-08-07
US20040048854A1 (en) 2004-03-11
EP1513846A1 (de) 2005-03-16
WO2003101997A1 (en) 2003-12-11
US7297789B2 (en) 2007-11-20
SI1513846T1 (sl) 2011-11-30
DE60336226D1 (de) 2011-04-14

Similar Documents

Publication Publication Date Title
ATE500258T1 (de) Verfahren zur herstellung von olanzapin form i
SG145744A1 (en) Process for the preparation of 4-amino-3- quinolinecarbonitriles
BR0114031A (pt) Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina
DE60202648D1 (de) Verfahren zur Herstellung von kuppelförmigen Gegenständen mit grossem Durchmesser
AU2958502A (en) Method for the production of water-in-water polymer dispersions
ATE371660T1 (de) Verfahren zur herstellung von olanzapine und ein zwischenprodukt dafür
DE69611003D1 (de) Verfahren zur Herstellung eines Thieno(2,3-B)(1,5)benzodiazepinderivats
DK1620439T3 (da) Hidtil ukendte polymorfer af olanzapinhydrochlorid
ATE516267T1 (de) Vefahren zur herstellung von lactamen
DE602004009962D1 (de) Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen
WO2005090359A3 (en) Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof
ATE359287T1 (de) Ein verfahren zur herstellung von clopidogrel
WO2003037903A8 (en) Olanzapine dihydrate-ii a process for its preparation and use thereof
ATE220550T1 (de) Verfahren zur behandlung von wahrnehmungsstörungen
ATE269339T1 (de) Verfahren zur herstellung von (3as)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrolo( ,1-c)(1,2, 4)benzothiadiazin
DE602006021792D1 (de) Verfahren zur herstellung von olanzapin
DK1392698T3 (da) Fremgangsmåde til fremstilling af 6-aryl-4H-s-triazolo-[3,4-c]thieno[2,3-e]-1,4-diazepiner
ATE287399T1 (de) Verfahren zur herstellung eines pgd2-antagonisten
ECSP961694A (es) Procedimeinto para preparar olanzapina (caso x - 9992m)
ATE412000T1 (de) Verfahren zur herstellung von n-demethylolanzapin
DE60205017D1 (de) Verfahren zur Herstellung 2-hydroxymethyl-2, 3- dihydro-thieno(3, 4-b) (1, 4) dioxine-5, 7-dicarbonsaürediester
AU2002249279A1 (en) Method for the production of 6-aryl-4h-s-triazolo(3,4-c)-thieno(2,3-e)-1,4-diazepines
ATE279416T1 (de) Verfahren zur herstellung von 6-aryl-4h-s- triazolo(3,4-c)-thieno(2,3-e)-1,4-diazepinen
PL350717A1 (en) Method of obtaining 4-amino 2-methyl-10h-thiene[2,3-b][1,5]benzodiazepine and method of obtaining olanzapine
PL355037A1 (en) New method of manufacture of olanzapine

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties