CA2464947C - Polytherapie pour le traitement de maladie - Google Patents

Polytherapie pour le traitement de maladie Download PDF

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Publication number
CA2464947C
CA2464947C CA2464947A CA2464947A CA2464947C CA 2464947 C CA2464947 C CA 2464947C CA 2464947 A CA2464947 A CA 2464947A CA 2464947 A CA2464947 A CA 2464947A CA 2464947 C CA2464947 C CA 2464947C
Authority
CA
Canada
Prior art keywords
antigen
alt
chemotherapeutic drug
patient
monoclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2464947A
Other languages
English (en)
Other versions
CA2464947A1 (fr
Inventor
Birgit C. Schultes
Christopher F. Nicodemus
Antoine Noujaim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Quest Pharmatech Inc
Oncoquest Inc
Oncoquest Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Pharmatech Inc, Oncoquest Inc, Oncoquest Pharmaceuticals Inc filed Critical Quest Pharmatech Inc
Publication of CA2464947A1 publication Critical patent/CA2464947A1/fr
Application granted granted Critical
Publication of CA2464947C publication Critical patent/CA2464947C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des procédés permettant de traiter le cancer, qui consistent à administrer à un patient souffrant du cancer un anticorps monoclonal xénotypique et un produit chimiothérapeutique. L'invention concerne également un procédé permettant d'induire une réponse immunitaire de l'hôte chez un patient contre un antigène tumoral in vivo à épitopes multiples présent dans le sérum de l'hôte, ledit antigène ne déclenchant pas une réponse immunitaire de l'hôte, qui consiste à administrer au patient un produit chimiothérapeutique et une composition comportant un liant qui se lie spécifiquement à un premier épitope sur l'antigène et à permettre au liant de former une paire agent de liaison/antigène, la réponse immunitaire d'hôte étant déclenchée contre un second épitope sur l'antigène.
CA2464947A 2001-10-26 2002-10-28 Polytherapie pour le traitement de maladie Expired - Lifetime CA2464947C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33924001P 2001-10-26 2001-10-26
US60/339,240 2001-10-26
PCT/IB2002/005794 WO2003034977A2 (fr) 2001-10-26 2002-10-28 Polytherapie pour le traitement de maladie

Publications (2)

Publication Number Publication Date
CA2464947A1 CA2464947A1 (fr) 2003-05-01
CA2464947C true CA2464947C (fr) 2012-05-22

Family

ID=23328122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2464947A Expired - Lifetime CA2464947C (fr) 2001-10-26 2002-10-28 Polytherapie pour le traitement de maladie

Country Status (9)

Country Link
AT (1) AT500649A1 (fr)
AU (1) AU2002358246B2 (fr)
CA (1) CA2464947C (fr)
CH (1) CH696871A5 (fr)
DE (1) DE10297379T5 (fr)
ES (1) ES2304264A1 (fr)
GB (1) GB2397018B (fr)
NO (1) NO20042166L (fr)
WO (1) WO2003034977A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8038994B2 (en) 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
WO2008091643A2 (fr) * 2007-01-23 2008-07-31 Altarex Medical Corp. Système de culture in vitro pour évaluer la synergie du ciblage de voies immunosuppressives concomitantes à une immunothérapie

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027637A1 (fr) * 1993-05-27 1994-12-08 Uwe Wagner Anticorps monoclonaux anti-ca125 et antiidiotypiques, et compositions pharmaceutiques les contenant
SI0910407T1 (en) * 1996-05-15 2003-10-31 Altarex Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
AT500848B1 (de) * 1999-06-25 2008-01-15 Genentech Inc Humanisierte anti-erbb2-antikörper
AU5286999A (en) * 1999-07-23 2001-02-13 Glaxo Group Limited Combination of an anti-ep-cam antibody with a chemotherapeutic agent
DE60018761T2 (de) * 1999-08-18 2006-02-02 Altarex Medical Corp., Edmonton Therapeutischer antikörper gegen das muc-1-antigen und verfahren zu dessen verwendung
PL202369B1 (pl) * 1999-08-27 2009-06-30 Genentech Inc Zastosowanie przeciwciała skierowanego przeciw ErbB2, zastosowanie przeciwciała skierowanego przeciw ErbB oraz zestaw zawierający to przeciwciało
WO2001059452A2 (fr) * 2000-02-08 2001-08-16 Altarex Corp. Determination de l'efficacite d'une therapie par anticorps xenotypiques
US20050031619A1 (en) * 2001-03-21 2005-02-10 Nicodemus Christopher F. Therapeutic compositions that alter the immune response

Also Published As

Publication number Publication date
AT500649A1 (de) 2006-02-15
WO2003034977A2 (fr) 2003-05-01
CA2464947A1 (fr) 2003-05-01
AU2002358246B2 (en) 2008-02-28
GB0409191D0 (en) 2004-05-26
DE10297379T5 (de) 2004-10-14
WO2003034977A3 (fr) 2004-05-27
GB2397018A (en) 2004-07-14
ES2304264A1 (es) 2008-10-01
GB2397018B (en) 2006-05-31
CH696871A5 (de) 2008-01-15
NO20042166L (no) 2004-05-25

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Effective date: 20221028