CA2490806C - Dispositif et procede servant a effectuer une synthese chimique en phase solide - Google Patents

Dispositif et procede servant a effectuer une synthese chimique en phase solide Download PDF

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Publication number
CA2490806C
CA2490806C CA002490806A CA2490806A CA2490806C CA 2490806 C CA2490806 C CA 2490806C CA 002490806 A CA002490806 A CA 002490806A CA 2490806 A CA2490806 A CA 2490806A CA 2490806 C CA2490806 C CA 2490806C
Authority
CA
Canada
Prior art keywords
receiving container
reactor
container holder
bore
receiving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002490806A
Other languages
English (en)
Other versions
CA2490806A1 (fr
Inventor
Joseph W. Guiles
Gregory Shutske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0225631.1A external-priority patent/GB0225631D0/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of CA2490806A1 publication Critical patent/CA2490806A1/fr
Application granted granted Critical
Publication of CA2490806C publication Critical patent/CA2490806C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B01L3/50855—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
    • B01J2219/00326—Movement by rotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un dispositif conçu pour être utilisé dans des procédés de synthèse chimique en phase solide. Ce dispositif permet de séparer un produit clivé de la phase solide utilisée pour préparer ce produit et d'extraire ensuite la phase solide du dispositif. Ce dernier permet au produit clivé de se concentrer à l'intérieur dudit dispositif sans transfert vers un autre dispositif.
CA002490806A 2002-07-05 2003-07-02 Dispositif et procede servant a effectuer une synthese chimique en phase solide Expired - Fee Related CA2490806C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39399902P 2002-07-05 2002-07-05
US60/393,999 2002-07-05
GBGB0225631.1A GB0225631D0 (en) 2002-07-05 2002-11-02 Apparatus and method for use in solid phase chemical synthesis
GB0225631.1 2002-11-02
PCT/US2003/020758 WO2004004886A2 (fr) 2002-07-05 2003-07-02 Dispositif et procede servant a effectuer une synthese chimique en phase solide

Publications (2)

Publication Number Publication Date
CA2490806A1 CA2490806A1 (fr) 2004-01-15
CA2490806C true CA2490806C (fr) 2008-10-07

Family

ID=30117124

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002490806A Expired - Fee Related CA2490806C (fr) 2002-07-05 2003-07-02 Dispositif et procede servant a effectuer une synthese chimique en phase solide

Country Status (7)

Country Link
US (1) US20080280784A1 (fr)
EP (1) EP1670577A2 (fr)
JP (1) JP2006513835A (fr)
AU (1) AU2003247689A1 (fr)
CA (1) CA2490806C (fr)
MX (1) MXPA05000047A (fr)
WO (1) WO2004004886A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0301392D0 (en) * 2003-01-22 2003-02-19 Millennium Pharm Inc Solid supports
JP2007040964A (ja) * 2005-05-25 2007-02-15 Enplas Corp 流体取扱装置およびそれに用いる流体取扱ユニット
JP4680037B2 (ja) 2005-11-14 2011-05-11 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
JP4842788B2 (ja) * 2006-03-16 2011-12-21 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
EP2148206B1 (fr) * 2008-07-25 2015-11-18 F.Hoffmann-La Roche Ag Système de laboratoire pour la manipulation de portoir de tubes d'échantillons, et élément d'alignement pour portoirs de tubes d'échantillons et ensemble recevant le plateau de portoirs
EP2189218A1 (fr) * 2008-11-12 2010-05-26 F. Hoffmann-Roche AG Séparation utilisant un couvercle de plaque multipuits
KR102207600B1 (ko) * 2016-06-30 2021-01-25 선전 와이에이치엘오 바이오텍 캄파니 리미티드 반응기에서 시약을 분리하는 장치
EP3823759B1 (fr) * 2018-07-16 2022-03-23 Brand Gmbh + Co Kg Dispositif de thermorégulation pour récipients de laboratoire
CN112659570B (zh) * 2021-01-08 2022-07-12 深圳市柏明胜医疗器械有限公司 一种采血试管自动化处理器械

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1598143A1 (de) * 1966-10-15 1970-05-21 Rudolf Brand Fabrik Fuer Labor Zentrifugenzelle,insbesondere fuer Ultrazentrifugen
US4244694A (en) * 1978-03-31 1981-01-13 Union Carbide Corporation Reactor/separator device for use in automated solid phase immunoassay
US4510119A (en) * 1982-05-07 1985-04-09 Centocor, Inc. Diagnostic test bead transfer apparatus
US4941867A (en) * 1989-08-04 1990-07-17 Tomy Seiko Co., Ltd. Container rotor for a centrifugal separator
US4970165A (en) * 1989-09-05 1990-11-13 Montefiore Hospital Association Of Western Pennsylvania Cell harvester tray
EP0558473A1 (fr) * 1989-11-08 1993-09-08 Fmc Corporation Tube centrifuge combine et moyen de selection poreux pour la separation et la recuperation de matieres biologiques
DE4303501A1 (de) * 1993-02-06 1994-08-11 Hans Schwartz Haltevorrichtung
US5456360A (en) * 1994-09-30 1995-10-10 The Perkin-Elmer Corporation Holder assembly for reaction tubes
US5578270A (en) * 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
GB9703779D0 (en) * 1997-02-24 1997-04-16 Oxford Asymmetry Ltd Reaction apparatus and method of using the same
US5888831A (en) * 1997-03-05 1999-03-30 Gautsch; James W. Liquid-sample-separation laboratory device and method particularly permitting ready extraction by syringe of the separated liquid sample
US6190619B1 (en) * 1997-06-11 2001-02-20 Argonaut Technologies, Inc. Systems and methods for parallel synthesis of compounds
DE19734135A1 (de) * 1997-08-07 1999-02-11 Boehringer Mannheim Gmbh System zum Zurverfügungstellen biologischer Materialien
US6121054A (en) * 1997-11-19 2000-09-19 Trega Biosciences, Inc. Method for separation of liquid and solid phases for solid phase organic syntheses
US6436351B1 (en) * 1998-07-15 2002-08-20 Deltagen Research Laboratories, L.L.C. Microtitre chemical reaction system
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
AU779983B2 (en) * 1999-12-13 2005-02-24 Illumina, Inc. Oligonucleotide synthesizer using centrifugal force
US6503457B1 (en) * 2000-04-14 2003-01-07 Discovery Partners International, Inc. Container and method for high volume treatment of samples on solid supports
EP1311345A1 (fr) * 2000-04-21 2003-05-21 University of Rochester Cuve a reaction biphasique et procedes d'utilisation
JP2002000255A (ja) * 2000-06-22 2002-01-08 Hitachi Ltd 核酸抽出装置

Also Published As

Publication number Publication date
JP2006513835A (ja) 2006-04-27
MXPA05000047A (es) 2005-04-08
EP1670577A2 (fr) 2006-06-21
US20080280784A1 (en) 2008-11-13
CA2490806A1 (fr) 2004-01-15
WO2004004886A3 (fr) 2004-02-26
AU2003247689A1 (en) 2004-01-23
WO2004004886A2 (fr) 2004-01-15

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