CA2500940A1 - Utilisation de derives d'iminosucre pour inhiber l'activite du canal ionique - Google Patents
Utilisation de derives d'iminosucre pour inhiber l'activite du canal ionique Download PDFInfo
- Publication number
- CA2500940A1 CA2500940A1 CA002500940A CA2500940A CA2500940A1 CA 2500940 A1 CA2500940 A1 CA 2500940A1 CA 002500940 A CA002500940 A CA 002500940A CA 2500940 A CA2500940 A CA 2500940A CA 2500940 A1 CA2500940 A1 CA 2500940A1
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- Prior art keywords
- alkyl
- linear
- branched
- aryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 210000001519 tissue Anatomy 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000010463 virion release Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- FHQVHHIBKUMWTI-OTMQOFQLSA-N {1-hexadecanoyl-2-[(Z)-octadec-9-enoyl]-sn-glycero-3-phospho}ethanolamine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC FHQVHHIBKUMWTI-OTMQOFQLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Méthodes et kits permettant de traiter l'infection due au virus de l'hépatite C (VHC) par administration d'un composé dérivé d'iminosucre capable d'inhiber l'activité de la protéine p7 de VHC, et méthodes permettant de cribler des composés qui inhibent l'activité de la protéine p7 ou des variantes de ladite protéine. Les composés imino à substitution N selon la présente invention et les compositions pharmaceutiques les contenant inhibent la capacité de p7 de VHC de perméabiliser les membranes. Les iminosucres dérivés de pipéridines N-alkylées sont des composés particulièrement efficaces. La présente invention concerne également des méthodes de criblage d'agents antiviraux potentiels contre le VHC.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41256002P | 2002-09-23 | 2002-09-23 | |
| US60/412,560 | 2002-09-23 | ||
| PCT/IB2003/006471 WO2004047719A2 (fr) | 2002-09-23 | 2003-09-23 | Utilisation de derives d'iminosucre pour inhiber l'activite du canal ionique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2500940A1 true CA2500940A1 (fr) | 2004-06-10 |
Family
ID=32393265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002500940A Abandoned CA2500940A1 (fr) | 2002-09-23 | 2003-09-23 | Utilisation de derives d'iminosucre pour inhiber l'activite du canal ionique |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1556036A2 (fr) |
| JP (1) | JP2006515577A (fr) |
| KR (1) | KR20050092103A (fr) |
| CN (1) | CN1694696A (fr) |
| AU (1) | AU2003302370A1 (fr) |
| CA (1) | CA2500940A1 (fr) |
| WO (1) | WO2004047719A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557764B2 (en) | 2007-01-26 | 2013-10-15 | The Regents Of The University Of Colorado, A Body Corporate | Methods of modulating immune function |
| AU2008317374B2 (en) | 2007-10-23 | 2015-03-19 | The Regents Of The University Of Colorado | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
| US20100166782A1 (en) * | 2008-07-25 | 2010-07-01 | Martha Karen Newell | Clip inhibitors and methods of modulating immune function |
| JP5600329B2 (ja) * | 2009-02-23 | 2014-10-01 | ユナイテッド セラピューティクス コーポレーション | イミノ糖およびウイルス性疾患を治療する方法 |
| CN104703597A (zh) | 2012-06-06 | 2015-06-10 | 尤尼特尔滤过性微生物学有限责任公司 | 新型亚氨基糖及它们的应用 |
| CN113150076B (zh) * | 2021-03-03 | 2022-05-31 | 天津医科大学 | 环五肽的合成方法及其在抗丙肝药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310745A (en) * | 1988-11-03 | 1994-05-10 | G. D. Searle & Co. | Antiviral compounds |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| DE69830241T2 (de) * | 1997-02-14 | 2006-01-26 | G.D. Searle Llc, Chicago | Verwendung von n-substituierten 1,5-dideoxy-1,5-imino-d-glucitol verbindungen in der kombinationstherapie der vom hepatitisvirus verursachten infektionen |
| ATE402701T1 (de) * | 1999-02-12 | 2008-08-15 | United Therapeutics Corp | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen |
| ES2302697T3 (es) * | 1999-08-10 | 2008-08-01 | The Chancellor, Masters And Scholars Of The University Of Oxford | Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales. |
| EP1261339A1 (fr) * | 2000-02-14 | 2002-12-04 | Pharmacia Corporation | UTILISATION DE COMPOSES 1,5-DIDESOXY-1,5-IMINO-D-GLUCITOL i N /i -SUBSTITUES POUR LE TRAITEMENT DES INFECTIONS PAR UN VIRUS D'HEPATITE |
-
2003
- 2003-09-23 EP EP03811849A patent/EP1556036A2/fr not_active Withdrawn
- 2003-09-23 CA CA002500940A patent/CA2500940A1/fr not_active Abandoned
- 2003-09-23 CN CNA038252007A patent/CN1694696A/zh active Pending
- 2003-09-23 WO PCT/IB2003/006471 patent/WO2004047719A2/fr not_active Ceased
- 2003-09-23 JP JP2004554867A patent/JP2006515577A/ja active Pending
- 2003-09-23 KR KR1020057004647A patent/KR20050092103A/ko not_active Withdrawn
- 2003-09-23 AU AU2003302370A patent/AU2003302370A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004047719A3 (fr) | 2005-05-26 |
| WO2004047719A2 (fr) | 2004-06-10 |
| KR20050092103A (ko) | 2005-09-20 |
| AU2003302370A1 (en) | 2004-06-18 |
| EP1556036A2 (fr) | 2005-07-27 |
| CN1694696A (zh) | 2005-11-09 |
| JP2006515577A (ja) | 2006-06-01 |
| AU2003302370A8 (en) | 2004-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20080923 |