CA2502017A1 - Derives de n-(4-(piperazine-1-yl)-phenyl-2-oxazolidinone-5-carboxamides et composes associes servant d'agents antibacteriens - Google Patents

Derives de n-(4-(piperazine-1-yl)-phenyl-2-oxazolidinone-5-carboxamides et composes associes servant d'agents antibacteriens Download PDF

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Publication number
CA2502017A1
CA2502017A1 CA002502017A CA2502017A CA2502017A1 CA 2502017 A1 CA2502017 A1 CA 2502017A1 CA 002502017 A CA002502017 A CA 002502017A CA 2502017 A CA2502017 A CA 2502017A CA 2502017 A1 CA2502017 A1 CA 2502017A1
Authority
CA
Canada
Prior art keywords
methyl
oxo
oxazolidin
phenyl
oxobutanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002502017A
Other languages
English (en)
Inventor
Christina R. Harris
Jackson Boling Hester, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2502017A1 publication Critical patent/CA2502017A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des agents antibactériens représentés par la formule (I), ou des sels pharmaceutiquement acceptables desdits agents : A étant une structure i, ii, iii ou iv ; W étant N(H)C(X)-R¿1?, het ou Y-HET, het ou Y-HET étant éventuellement substitué avec =S ou =O, à la condition que, si A est la structure iv, W n'est ni het ni Y-HET ; X étant O ou S ; et, Y étant NH, O ou S.
CA002502017A 2002-11-21 2003-11-19 Derives de n-(4-(piperazine-1-yl)-phenyl-2-oxazolidinone-5-carboxamides et composes associes servant d'agents antibacteriens Abandoned CA2502017A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42802502P 2002-11-21 2002-11-21
US60/428,025 2002-11-21
US44553003P 2003-02-06 2003-02-06
US60/445,530 2003-02-06
PCT/IB2003/005355 WO2004045616A1 (fr) 2002-11-21 2003-11-19 Derives de n-(4-(piperazine-1-yl)-phenyl-2-oxazolidinone-5-carboxamides et composes associes servant d'agents antibacteriens

Publications (1)

Publication Number Publication Date
CA2502017A1 true CA2502017A1 (fr) 2004-06-03

Family

ID=32329201

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002502017A Abandoned CA2502017A1 (fr) 2002-11-21 2003-11-19 Derives de n-(4-(piperazine-1-yl)-phenyl-2-oxazolidinone-5-carboxamides et composes associes servant d'agents antibacteriens

Country Status (13)

Country Link
US (1) US7141570B2 (fr)
EP (1) EP1565186B1 (fr)
JP (1) JP2006509035A (fr)
AR (1) AR042086A1 (fr)
AT (1) ATE344036T1 (fr)
AU (1) AU2003280143A1 (fr)
BR (1) BR0316483A (fr)
CA (1) CA2502017A1 (fr)
DE (1) DE60309504T2 (fr)
ES (1) ES2271660T3 (fr)
MX (1) MXPA05005472A (fr)
TW (1) TW200413360A (fr)
WO (1) WO2004045616A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2170874A4 (fr) * 2007-06-22 2011-08-31 Orchid Res Lab Ltd Nouveaux composés et leur utilisation
BRPI0912245A2 (pt) 2008-03-05 2019-09-24 Takeda Pharmaceuticals Co composto, prodroga, medicamento, métodos de suprimir produção de açúcar em um mamífero e para a profilaxia ou o tratamento de diabetes em um mamífero, e, uso do composto
CN102224151A (zh) 2008-11-20 2011-10-19 万能药生物有限公司 新的抗微生物剂
WO2013189646A1 (fr) 2012-06-22 2013-12-27 Henkel Ag & Co. Kgaa Substances photolabiles renfermant un parfum

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* Cited by examiner, † Cited by third party
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US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
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US5182403A (en) 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
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EP0610265B1 (fr) 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Aryl- et heteroarylphenyloxazolidinones substituees, utilisees comme agents antibacteriens
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CA2136324A1 (fr) 1992-07-08 1994-01-20 Steven Joseph Brickner 5'-indolinyloxazolidinones utiles pour la lutte contre le bacille de koch
WO1994013649A1 (fr) 1992-12-08 1994-06-23 The Upjohn Company Agents antibacteriens a base de phenyloxazolidinone substituee par tropone
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
CA2174107C (fr) 1993-11-22 2005-04-12 Steven J. Brickner Esters de derives de substitution d'hydroxyacetyl-piperazinyl-phenyl-oxazolidinones
JPH0873455A (ja) 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
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DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
JP3933198B2 (ja) 1994-10-26 2007-06-20 ファルマシア・アンド・アップジョン・カンパニー フェニルオキサゾリジノン抗菌剤
PT792273E (pt) 1994-11-15 2003-06-30 Upjohn Co Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas
ATE205205T1 (de) 1995-02-03 2001-09-15 Upjohn Co Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE69614847T2 (de) 1995-05-11 2002-04-04 Pharmacia & Upjohn Co., Kalamazoo Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
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DE69631347T2 (de) 1995-09-15 2004-10-07 Upjohn Co Aminoaryl oxazolidinone n-oxide
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Also Published As

Publication number Publication date
AR042086A1 (es) 2005-06-08
US20040142939A1 (en) 2004-07-22
ATE344036T1 (de) 2006-11-15
EP1565186B1 (fr) 2006-11-02
BR0316483A (pt) 2005-10-11
US7141570B2 (en) 2006-11-28
EP1565186A1 (fr) 2005-08-24
MXPA05005472A (es) 2005-07-25
AU2003280143A1 (en) 2004-06-15
TW200413360A (en) 2004-08-01
WO2004045616A1 (fr) 2004-06-03
JP2006509035A (ja) 2006-03-16
ES2271660T3 (es) 2007-04-16
DE60309504T2 (de) 2007-05-16
DE60309504D1 (de) 2006-12-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued