CA2516467A1 - Trimeric macrocyclically substituted benzene derivatives - Google Patents

Trimeric macrocyclically substituted benzene derivatives Download PDF

Info

Publication number
CA2516467A1
CA2516467A1 CA002516467A CA2516467A CA2516467A1 CA 2516467 A1 CA2516467 A1 CA 2516467A1 CA 002516467 A CA002516467 A CA 002516467A CA 2516467 A CA2516467 A CA 2516467A CA 2516467 A1 CA2516467 A1 CA 2516467A1
Authority
CA
Canada
Prior art keywords
tris
mmol
stands
hours
degree
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002516467A
Other languages
English (en)
French (fr)
Inventor
Johannes Platzek
Hanns-Joachim Weinmann
Heiko Schirmer
Jose Luis Martin
Juan R. Harto
Bjoern Riefke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of CA2516467A1 publication Critical patent/CA2516467A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002516467A 2003-02-19 2003-12-12 Trimeric macrocyclically substituted benzene derivatives Abandoned CA2516467A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10307759A DE10307759B3 (de) 2003-02-19 2003-02-19 Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
DE10307759.6 2003-02-19
PCT/EP2003/014149 WO2004074267A1 (de) 2003-02-19 2003-12-12 Trimere makrocyclisch substituierte benzolderivate

Publications (1)

Publication Number Publication Date
CA2516467A1 true CA2516467A1 (en) 2004-09-02

Family

ID=32891780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002516467A Abandoned CA2516467A1 (en) 2003-02-19 2003-12-12 Trimeric macrocyclically substituted benzene derivatives

Country Status (16)

Country Link
EP (1) EP1594851A1 (de)
JP (1) JP2006514664A (de)
KR (1) KR20050105474A (de)
CN (1) CN1753878A (de)
AR (1) AR043205A1 (de)
AU (1) AU2003290032B2 (de)
BR (1) BR0318125A (de)
CA (1) CA2516467A1 (de)
CR (1) CR7937A (de)
DE (1) DE10307759B3 (de)
EC (1) ECSP056026A (de)
MX (1) MXPA05008781A (de)
NO (1) NO20054291L (de)
RU (1) RU2005128834A (de)
WO (1) WO2004074267A1 (de)
ZA (1) ZA200507437B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513279B2 (en) 1999-07-14 2013-08-20 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9254262B2 (en) 2008-03-13 2016-02-09 Almirall, S.A. Dosage and formulation
US9737520B2 (en) 2011-04-15 2017-08-22 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
US10085974B2 (en) 2008-03-13 2018-10-02 Almirall, S.A. Dosage and formulation

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004023093B3 (de) 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) * 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
US9233971B2 (en) * 2010-08-26 2016-01-12 Kunyuan Cui Lipomacrocycles and uses thereof
CN104721844B (zh) * 2015-02-02 2017-11-03 湖北大学 一种新型ct，mri，稀土荧光三功能微球及其制备方法和应用
CN104672259B (zh) * 2015-02-02 2017-04-05 湖北大学 一种含碘稀土铕(ⅲ)配合物及其制备方法和应用
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CN105254529B (zh) * 2015-09-21 2017-05-31 西南石油大学 一种树形席夫碱缓蚀剂的制备方法
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
JPH08510458A (ja) * 1993-06-02 1996-11-05 ブラッコ エッセ．ピ．ア． 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513279B2 (en) 1999-07-14 2013-08-20 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US8802699B2 (en) 1999-07-14 2014-08-12 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9056100B2 (en) 1999-07-14 2015-06-16 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9333195B2 (en) 1999-07-14 2016-05-10 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9687478B2 (en) 1999-07-14 2017-06-27 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US10034867B2 (en) 1999-07-14 2018-07-31 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US10588895B2 (en) 1999-07-14 2020-03-17 Almirall, S.A. Quinuclidine derivatives and medicinal compositions containing the same
US9254262B2 (en) 2008-03-13 2016-02-09 Almirall, S.A. Dosage and formulation
US10085974B2 (en) 2008-03-13 2018-10-02 Almirall, S.A. Dosage and formulation
US11000517B2 (en) 2008-03-13 2021-05-11 Almirall, S.A. Dosage and formulation
US9737520B2 (en) 2011-04-15 2017-08-22 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients

Also Published As

Publication number Publication date
BR0318125A (pt) 2006-02-07
AR043205A1 (es) 2005-07-20
NO20054291D0 (no) 2005-09-16
WO2004074267A1 (de) 2004-09-02
NO20054291L (no) 2005-11-17
RU2005128834A (ru) 2006-03-20
ZA200507437B (en) 2007-02-28
MXPA05008781A (es) 2006-03-10
KR20050105474A (ko) 2005-11-04
AU2003290032A1 (en) 2004-09-09
JP2006514664A (ja) 2006-05-11
DE10307759B3 (de) 2004-11-18
EP1594851A1 (de) 2005-11-16
CR7937A (es) 2006-02-07
AU2003290032B2 (en) 2009-04-23
CN1753878A (zh) 2006-03-29
ECSP056026A (es) 2006-01-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued