CA2521908A1 - Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) - Google Patents

Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) Download PDF

Info

Publication number: CA2521908A1
Authority: CA; Canada
Prior art keywords: phenylamino; methylethyl; fluorophenyl; pyrrole; dihydroxy
Prior art date: 2001-06-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002521908A

Other languages

English (en)

Other versions

CA2521908C (fr

Inventor

Stephen Robert Byrn

David Andrew Coates

Karen Sue Gushurst

Henry Grant Ii Morrison

Aeri Park

Petinka Ivanova Vlahova

Zheng Jane Li

Joseph Francis Krzyzaniak

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-29

Filing date

2002-05-21

Publication date

2003-01-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35452260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2521908(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-05-21 Application filed by Individual filed Critical Individual

2002-05-21 Priority claimed from CA002450111A external-priority patent/CA2450111C/fr

2003-01-16 Publication of CA2521908A1 publication Critical patent/CA2521908A1/fr

2006-04-25 Application granted granted Critical

2006-04-25 Publication of CA2521908C publication Critical patent/CA2521908C/fr

2022-05-21 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 2
229960005370 atorvastatin Drugs 0.000 title abstract 2
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 title 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title 1
SAGAISAEDMDRFK-UHFFFAOYSA-N 2-hydroxy-7-[2-hydroxy-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]heptanoic acid Chemical compound C=1C=CC=CC=1C1=C(O)N(CCCCCC(O)C(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 SAGAISAEDMDRFK-UHFFFAOYSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
238000001069 Raman spectroscopy Methods 0.000 abstract 1
159000000007 calcium salts Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000000634 powder X-ray diffraction Methods 0.000 abstract 1
238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

CA002521908A 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) Expired - Fee Related CA2521908C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US30204901P	2001-06-29	2001-06-29
US60/302,049		2001-06-29
CA002450111A CA2450111C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002450111A Division CA2450111C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Publications (2)

Publication Number	Publication Date
CA2521908A1 true CA2521908A1 (fr)	2003-01-16
CA2521908C CA2521908C (fr)	2006-04-25

Family

ID=35452260

Family Applications (14)

Application Number	Title	Priority Date	Filing Date
CA002521833A Expired - Fee Related CA2521833C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002522899A Expired - Fee Related CA2522899C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521828A Expired - Fee Related CA2521828C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521933A Expired - Fee Related CA2521933C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521993A Abandoned CA2521993A1 (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide¬r-(r,r)\|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl\|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521980A Expired - Fee Related CA2521980C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide[r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521776A Expired - Fee Related CA2521776C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521887A Expired - Fee Related CA2521887C (fr)	2001-06-29	2002-05-21	Crystalline forms of [r-(r,r)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521891A Expired - Fee Related CA2521891C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521953A Expired - Fee Related CA2521953C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521792A Expired - Fee Related CA2521792C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521958A Expired - Fee Related CA2521958C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521908A Expired - Fee Related CA2521908C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521956A Expired - Fee Related CA2521956C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Family Applications Before (12)

Application Number	Title	Priority Date	Filing Date
CA002521833A Expired - Fee Related CA2521833C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002522899A Expired - Fee Related CA2522899C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521828A Expired - Fee Related CA2521828C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521933A Expired - Fee Related CA2521933C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521993A Abandoned CA2521993A1 (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide¬r-(r,r)\|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl\|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521980A Expired - Fee Related CA2521980C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide[r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521776A Expired - Fee Related CA2521776C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521887A Expired - Fee Related CA2521887C (fr)	2001-06-29	2002-05-21	Crystalline forms of [r-(r,r)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)
CA002521891A Expired - Fee Related CA2521891C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521953A Expired - Fee Related CA2521953C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521792A Expired - Fee Related CA2521792C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521958A Expired - Fee Related CA2521958C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CA002521956A Expired - Fee Related CA2521956C (fr)	2001-06-29	2002-05-21	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Country Status (1)

Country	Link
CA (14)	CA2521833C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8080672B2 (en)	2005-12-13	2011-12-20	Teva Pharmaceutical Industries Ltd.	Crystal form of atorvastatin hemi-calcium and processes for preparation thereof

2002
- 2002-05-21 CA CA002521833A patent/CA2521833C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002522899A patent/CA2522899C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521828A patent/CA2521828C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521933A patent/CA2521933C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521993A patent/CA2521993A1/fr not_active Abandoned
- 2002-05-21 CA CA002521980A patent/CA2521980C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521776A patent/CA2521776C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521887A patent/CA2521887C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521891A patent/CA2521891C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521953A patent/CA2521953C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521792A patent/CA2521792C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521958A patent/CA2521958C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521908A patent/CA2521908C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521956A patent/CA2521956C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2521887A1 (fr)	2003-01-16
CA2522899C (fr)	2006-04-25
CA2521776A1 (fr)	2003-01-16
CA2521958A1 (fr)	2003-01-16
CA2521828C (fr)	2006-04-25
CA2521933C (fr)	2006-03-21
CA2521980A1 (fr)	2003-01-16
CA2522899A1 (fr)	2003-01-16
CA2521887C (fr)	2006-04-25
CA2521833A1 (fr)	2003-01-16
CA2521792A1 (fr)	2003-01-16
CA2521776C (fr)	2006-04-25
CA2521993A1 (fr)	2003-01-16
CA2521833C (fr)	2006-04-25
CA2521980C (fr)	2006-08-29
CA2521828A1 (fr)	2003-01-16
CA2521891C (fr)	2006-04-25
CA2521933A1 (fr)	2003-01-16
CA2521958C (fr)	2006-08-29
CA2521908C (fr)	2006-04-25
CA2521956A1 (fr)	2003-01-16
CA2521891A1 (fr)	2003-01-16
CA2521953C (fr)	2006-03-14
CA2521953A1 (fr)	2003-01-16
CA2521956C (fr)	2006-04-25
CA2521792C (fr)	2006-04-25

Legal Events

Date	Code	Title	Description
2005-11-03	EEER	Examination request
2019-07-02	MKLA	Lapsed	Effective date: 20190521

Publication	Publication Date	Title
CA2450111A1 (fr)	2003-01-16	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA2220018A1 (fr)	1997-02-06	Formes cristallines d'hemi-sel de calcium d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique(atorvastatine)
IL122162A0 (en)	1998-04-05	Crystalline form III atorvastatin and pharmceutical compositions containing it
NZ533935A (en)	2006-03-31	Crystalline [R-(R,R)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-heptanoic acid calcium salt (2:1)
EP2540704A3 (fr)	2013-05-15	Formes de sel de bénéthamine avec d'atorvastatine
CA2521908A1 (fr)	2003-01-16	Formes cristallines de sel hemicalcique d'acide [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
TH61086A (th)	2004-03-10	รูปแบบผลึกของเกลือแคลเซียม (2

CA2521908A1 - Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) - Google Patents