CA2536181A1 - Polymer compositions and methods for their use - Google Patents

Polymer compositions and methods for their use Download PDF

Info

Publication number: CA2536181A1
Authority: CA; Canada
Prior art keywords: fibrotic agent; polymer; reactants; agent; inhibitor
Prior art date: 2003-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002536181A

Other languages

English (en)

French (fr)

Inventor

William L. Hunter

David M. Gravett

Philip M. Toleikis

Arpita Maiti

Richard T. Liggins

Aniko Takacs-Cox

Rui Avelar

Troy A. E. Loss

Dechi Guan

Kaiyue Wang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

IPXMEDICAL LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-20

Filing date

2004-11-22

Publication date

2005-06-09

2004-11-10 Priority claimed from US10/986,231 external-priority patent/US20050181977A1/en

2004-11-22 Application filed by Individual filed Critical Individual

2005-06-09 Publication of CA2536181A1 publication Critical patent/CA2536181A1/en

Status Abandoned legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims 1889
229920000642 polymer Polymers 0.000 title claims 568
239000000203 mixture Substances 0.000 title claims 62
239000003795 chemical substances by application Substances 0.000 claims 1183
230000003510 anti-fibrotic effect Effects 0.000 claims 1148
239000000376 reactant Substances 0.000 claims 516
150000001875 compounds Chemical class 0.000 claims 247
229960005475 antiinfective agent Drugs 0.000 claims 140
239000004599 antimicrobial Substances 0.000 claims 140
108010035532 Collagen Proteins 0.000 claims 130
102000008186 Collagen Human genes 0.000 claims 130
229920001436 collagen Polymers 0.000 claims 130
239000003112 inhibitor Substances 0.000 claims 126
229920000233 poly(alkylene oxides) Polymers 0.000 claims 68
239000005557 antagonist Substances 0.000 claims 56
102000004169 proteins and genes Human genes 0.000 claims 56
108090000623 proteins and genes Proteins 0.000 claims 56
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 54
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 52
210000001519 tissue Anatomy 0.000 claims 49
125000003277 amino group Chemical group 0.000 claims 48
125000003396 thiol group Chemical group [H]S* 0.000 claims 48
229940045799 anthracyclines and related substance Drugs 0.000 claims 42
108010039918 Polylysine Proteins 0.000 claims 28
239000003429 antifungal agent Substances 0.000 claims 28
230000015572 biosynthetic process Effects 0.000 claims 28
229940043355 kinase inhibitor Drugs 0.000 claims 28
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical group COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims 28
229920000656 polylysine Polymers 0.000 claims 28
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 27
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 27
235000014655 lactic acid Nutrition 0.000 claims 26
239000004310 lactic acid Substances 0.000 claims 26
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 24
-1 poly(ethylene glycol) Polymers 0.000 claims 24
229920001059 synthetic polymer Polymers 0.000 claims 22
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 21
229940123034 Heat shock protein 90 antagonist Drugs 0.000 claims 21
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical group C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 21
229940122696 MAP kinase inhibitor Drugs 0.000 claims 21
239000000556 agonist Substances 0.000 claims 21
YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 21
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 21
239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 21
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 21
108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 21
239000003757 phosphotransferase inhibitor Substances 0.000 claims 21
229960001237 podophyllotoxin Drugs 0.000 claims 21
YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims 21
238000003786 synthesis reaction Methods 0.000 claims 21
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 21
PGEGFAGJACEMIS-UHFFFAOYSA-N carbon dioxide;pyrrolidine-2,5-dione Chemical group O=C=O.O=C1CCC(=O)N1 PGEGFAGJACEMIS-UHFFFAOYSA-N 0.000 claims 20
WAVYAFBQOXCGSZ-UHFFFAOYSA-N 2-fluoropyrimidine Chemical group FC1=NC=CC=N1 WAVYAFBQOXCGSZ-UHFFFAOYSA-N 0.000 claims 14
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 14
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 14
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 14
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GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 14
108010010803 Gelatin Proteins 0.000 claims 14
229940118547 Guanylate cyclase stimulant Drugs 0.000 claims 14
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical group NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 14
VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical group NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 14
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 14
229940126033 PPAR agonist Drugs 0.000 claims 14
229930012538 Paclitaxel Natural products 0.000 claims 14
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 14
229940044684 anti-microtubule agent Drugs 0.000 claims 14
229920000229 biodegradable polyester Polymers 0.000 claims 14
239000004622 biodegradable polyester Substances 0.000 claims 14
229940127093 camptothecin Drugs 0.000 claims 14
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 14
GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 claims 14
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 14
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 14
229960005420 etoposide Drugs 0.000 claims 14
229940012952 fibrinogen Drugs 0.000 claims 14
229960002949 fluorouracil Drugs 0.000 claims 14
239000004052 folic acid antagonist Substances 0.000 claims 14
229920000159 gelatin Polymers 0.000 claims 14
239000008273 gelatin Substances 0.000 claims 14
235000019322 gelatine Nutrition 0.000 claims 14
235000011852 gelatine desserts Nutrition 0.000 claims 14
229960001330 hydroxycarbamide Drugs 0.000 claims 14
229960001592 paclitaxel Drugs 0.000 claims 14
239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 claims 14
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 14
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 14
229960002930 sirolimus Drugs 0.000 claims 14
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 14
229960001967 tacrolimus Drugs 0.000 claims 14
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 14
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 12
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 12
229920001223 polyethylene glycol Polymers 0.000 claims 12
210000004204 blood vessel Anatomy 0.000 claims 9
VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical group O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 7
DOEWDSDBFRHVAP-KRXBUXKQSA-N (E)-3-tosylacrylonitrile Chemical group CC1=CC=C(S(=O)(=O)\C=C\C#N)C=C1 DOEWDSDBFRHVAP-KRXBUXKQSA-N 0.000 claims 7
101710175516 14 kDa zinc-binding protein Proteins 0.000 claims 7
YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical group [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 claims 7
229940124125 5 Lipoxygenase inhibitor Drugs 0.000 claims 7
101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 7
SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 7
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 7
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102000055025 Adenosine deaminases Human genes 0.000 claims 7
108010088751 Albumins Proteins 0.000 claims 7
102000009027 Albumins Human genes 0.000 claims 7
229940122195 Alpha2 integrin antagonist Drugs 0.000 claims 7
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229940123413 Angiotensin II antagonist Drugs 0.000 claims 7
102000000412 Annexin Human genes 0.000 claims 7
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108010039627 Aprotinin Proteins 0.000 claims 7
229940122361 Bisphosphonate Drugs 0.000 claims 7
102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 7
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229940123587 Cell cycle inhibitor Drugs 0.000 claims 7
229940122444 Chemokine receptor antagonist Drugs 0.000 claims 7
108020004414 DNA Proteins 0.000 claims 7
108020005124 DNA Adducts Proteins 0.000 claims 7
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229940126161 DNA alkylating agent Drugs 0.000 claims 7
239000012624 DNA alkylating agent Substances 0.000 claims 7
230000005778 DNA damage Effects 0.000 claims 7
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101710088194 Dehydrogenase Proteins 0.000 claims 7
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229940122858 Elastase inhibitor Drugs 0.000 claims 7
229940118365 Endothelin receptor antagonist Drugs 0.000 claims 7
229940122586 Enkephalinase inhibitor Drugs 0.000 claims 7
102400001368 Epidermal growth factor Human genes 0.000 claims 7
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HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 7
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JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 claims 7
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229940122296 IKK2 inhibitor Drugs 0.000 claims 7
GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical group O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 claims 7
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102000029749 Microtubule Human genes 0.000 claims 7
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RRHONYZEMUNMJX-UHFFFAOYSA-N N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-methylbutan-2-ylamino)methyl]benzamide Chemical group C1=C(C(=O)N2CCN(CC2)C(C)=O)C(OC)=CC(C)=C1SC(S1)=CN=C1NC(=O)C1=CC=C(CNC(C)C(C)C)C=C1 RRHONYZEMUNMJX-UHFFFAOYSA-N 0.000 claims 7
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229940123924 Protein kinase C inhibitor Drugs 0.000 claims 7
229940123752 RNA synthesis inhibitor Drugs 0.000 claims 7
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LVBMFPUTQOHXQE-UHFFFAOYSA-N [2-[6-(diaminomethylideneamino)hexylamino]-2-oxoethyl] n-[4-(3-aminopropylamino)butyl]carbamate Chemical group NCCCNCCCCNC(=O)OCC(=O)NCCCCCCN=C(N)N LVBMFPUTQOHXQE-UHFFFAOYSA-N 0.000 claims 7
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NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 7
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229920002988 biodegradable polymer Polymers 0.000 claims 7
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150000004663 bisphosphonates Chemical group 0.000 claims 7
235000020964 calcitriol Nutrition 0.000 claims 7
239000011612 calcitriol Substances 0.000 claims 7
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical group C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 7
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DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 7
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 7
CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical group N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 7
229950009819 zotarolimus Drugs 0.000 claims 7
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239000003086 colorant Substances 0.000 claims 6
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238000010168 coupling process Methods 0.000 claims 5
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210000004392 genitalia Anatomy 0.000 claims 4
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210000002388 eustachian tube Anatomy 0.000 claims 3
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208000010412 Glaucoma Diseases 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
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230000017531 blood circulation Effects 0.000 claims 1
210000003169 central nervous system Anatomy 0.000 claims 1
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210000004351 coronary vessel Anatomy 0.000 claims 1
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239000012530 fluid Substances 0.000 claims 1
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229910052751 metal Inorganic materials 0.000 claims 1
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229910001092 metal group alloy Inorganic materials 0.000 claims 1
238000012806 monitoring device Methods 0.000 claims 1
210000003101 oviduct Anatomy 0.000 claims 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Surgery (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Prostheses (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002536181A 2003-11-20 2004-11-22 Polymer compositions and methods for their use Abandoned CA2536181A1 (en)

Applications Claiming Priority (15)

Application Number	Priority Date	Filing Date	Title
US52390803P	2003-11-20	2003-11-20
US60/523,908		2003-11-20
US52522603P	2003-11-24	2003-11-24
US60/525,226		2003-11-24
US52654103P	2003-12-03	2003-12-03
US60/526,541		2003-12-03
US56656904P	2004-04-28	2004-04-28
US60/566,569		2004-04-28
US58686104P	2004-07-09	2004-07-09
US60/586,861		2004-07-09
US61107704P	2004-09-17	2004-09-17
US60/611,077		2004-09-17
US10/986,231 US20050181977A1 (en)	2003-11-10	2004-11-10	Medical implants and anti-scarring agents
US10/986,231		2004-11-10
PCT/US2004/039389 WO2005051452A2 (en)	2003-11-20	2004-11-22	Polymer compositions and methods for their use

Publications (1)

Publication Number	Publication Date
CA2536181A1 true CA2536181A1 (en)	2005-06-09

Family

ID=34637499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002536181A Abandoned CA2536181A1 (en)	2003-11-20	2004-11-22	Polymer compositions and methods for their use

Country Status (6)

Country	Link
EP (1)	EP1684819A2 (de)
JP (1)	JP2007517543A (de)
AU (1)	AU2004293071A1 (de)
CA (1)	CA2536181A1 (de)
IL (1)	IL174641A0 (de)
WO (2)	WO2005051316A2 (de)

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2004
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- 2004-11-22 EP EP04816983A patent/EP1684819A2/de not_active Withdrawn
- 2004-11-22 CA CA002536181A patent/CA2536181A1/en not_active Abandoned
- 2004-11-22 AU AU2004293071A patent/AU2004293071A1/en not_active Abandoned
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- 2004-11-22 JP JP2006541670A patent/JP2007517543A/ja active Pending
2006
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Also Published As

Publication number	Publication date
WO2005051316A2 (en)	2005-06-09
WO2005051316A3 (en)	2010-01-28
JP2007517543A (ja)	2007-07-05
AU2004293071A1 (en)	2005-06-09
IL174641A0 (en)	2006-08-20
EP1684819A2 (de)	2006-08-02
WO2005051452A2 (en)	2005-06-09

Legal Events

Date	Code	Title	Description
2009-10-02	EEER	Examination request
2016-06-01	FZDE	Discontinued	Effective date: 20160420

Publication	Publication Date	Title
CA2536181A1 (en)	2005-06-09	Polymer compositions and methods for their use
US20050152941A1 (en)	2005-07-14	Soft tissue implants and anti-scarring agents