CA2582462C - Liants pour prions et procedes d'utilisation - Google Patents

Liants pour prions et procedes d'utilisation Download PDF

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Publication number
CA2582462C
CA2582462C CA2582462A CA2582462A CA2582462C CA 2582462 C CA2582462 C CA 2582462C CA 2582462 A CA2582462 A CA 2582462A CA 2582462 A CA2582462 A CA 2582462A CA 2582462 C CA2582462 C CA 2582462C
Authority
CA
Canada
Prior art keywords
binding
sample
prion
prion protein
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2582462A
Other languages
English (en)
Other versions
CA2582462A1 (fr
Inventor
David John Hammond
Ruben G. Carbonell
Honglue Shen
Patrick V. Gurgel
Viterose Wiltshire-Lyerly
Steven J. Burton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
North Carolina State University
Pathogen Removal and Diagnostic Technologies Inc
Original Assignee
North Carolina State University
Pathogen Removal and Diagnostic Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Carolina State University, Pathogen Removal and Diagnostic Technologies Inc filed Critical North Carolina State University
Publication of CA2582462A1 publication Critical patent/CA2582462A1/fr
Application granted granted Critical
Publication of CA2582462C publication Critical patent/CA2582462C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2582462A 2004-10-13 2005-10-13 Liants pour prions et procedes d'utilisation Expired - Fee Related CA2582462C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/962,670 2004-10-13
US10/962,670 US7510848B2 (en) 2003-04-04 2004-10-13 Prion protein binding materials and methods of use
PCT/US2005/036676 WO2006044459A2 (fr) 2004-10-13 2005-10-13 Liants pour prions et procedes d'utilisation

Publications (2)

Publication Number Publication Date
CA2582462A1 CA2582462A1 (fr) 2006-04-27
CA2582462C true CA2582462C (fr) 2013-08-06

Family

ID=36145798

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2582462A Expired - Fee Related CA2582462C (fr) 2004-10-13 2005-10-13 Liants pour prions et procedes d'utilisation

Country Status (17)

Country Link
US (1) US7510848B2 (fr)
EP (1) EP1802322A4 (fr)
JP (1) JP4897689B2 (fr)
KR (1) KR20070117533A (fr)
CN (1) CN101065136A (fr)
AP (1) AP2007003974A0 (fr)
AU (1) AU2005295773B2 (fr)
BR (1) BRPI0515970A (fr)
CA (1) CA2582462C (fr)
EA (1) EA200700847A1 (fr)
IL (1) IL182422A0 (fr)
MA (1) MA29004B1 (fr)
MX (1) MX2007004399A (fr)
NO (1) NO20072427L (fr)
TN (1) TNSN07136A1 (fr)
WO (1) WO2006044459A2 (fr)
ZA (1) ZA200702634B (fr)

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US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
ES2527408T3 (es) * 2002-12-03 2015-01-23 North Carolina State University Ligandos de proteínas priones y procedimientos de uso
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
EP1853915B1 (fr) * 2005-02-15 2011-10-12 Adlyfe, Inc. Procede de detection de proteines et de prions a repliement incorrect
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
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US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
HRP20192259T1 (hr) * 2009-04-15 2020-03-06 Abraxis Bioscience, Llc Pripravci nanočestica bez priona i metode njihove proizvodnje
WO2012015908A2 (fr) 2010-07-30 2012-02-02 Millipore Corporation Phase de chromatographie et procédé
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US20140255409A1 (en) * 2011-10-28 2014-09-11 Glycorex Transplantation Ab Method for extracorporeal elimination of one or more components from blood
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KR101363575B1 (ko) * 2012-08-07 2014-02-24 가천대학교 산학협력단 신부전증에 대한 신규 바이오마커 및 그의 용도
CN103336124B (zh) * 2012-12-11 2015-07-15 武汉工业学院 一种检测朊病毒蛋白(PrPSC)的方法和试剂盒
EP3188816B1 (fr) 2014-09-02 2021-06-09 EMD Millipore Corporation Support chromatographique comprenant des faisceaux poreux discrets de nanofibrilles
US20170298091A1 (en) 2014-12-08 2017-10-19 Emd Millipore Corporation Mixed Bed Ion Exchange Adsorber
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CA2995204A1 (fr) 2015-08-10 2017-02-16 Essenlix Corp. Dispositifs et procedes de dosages biochimiques pour des applications a etapes simplifiees, sur petits echantillons, a vitesse acceleree et faciles a utiliser
US10132794B2 (en) 2015-09-14 2018-11-20 Essenlix Corporation Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
KR20190057445A (ko) 2015-09-14 2019-05-28 에센릭스 코프. 샘플 특히 혈액샘플을 분석하기 위한 장치와 시스템 및 그 사용 방법
US10628693B2 (en) 2016-12-21 2020-04-21 Essenlix Corporation Devices and methods for authenticating a sample and use of the same
JP7003158B2 (ja) 2017-02-07 2022-01-20 エッセンリックス コーポレーション 圧縮開放流アッセイおよび使用
CA3053002A1 (fr) 2017-02-08 2018-08-16 Essenlix Corp. Extraction et dosage de matieres bio/chimiques
CA3052809A1 (fr) 2017-02-08 2018-08-23 Essenlix Corporation Dosages qmax et applications
WO2018148470A1 (fr) 2017-02-08 2018-08-16 Essenlix Corporation Collecte et manipulation d'échantillons pour analyse retardée
CN122234927A (zh) 2017-02-08 2026-06-19 上海宜晟生物科技有限公司 通过控制温度的分子操作和检测
US12569851B2 (en) 2017-02-08 2026-03-10 Essenlix Corporation Digital assay
CA3053114A1 (fr) 2017-02-09 2018-08-16 Essenlix Corporation Dosage utilisant differentes hauteurs d'espacement
CA3053132A1 (fr) 2017-02-09 2018-08-16 Essenlix Corp. Dosage avec amplification
JP2020507770A (ja) 2017-02-09 2020-03-12 エッセンリックス コーポレーション 比色アッセイ法
CA3053295A1 (fr) 2017-02-15 2018-08-23 Essenlix Corporation Dosage a changement rapide de temperature
CN111448449B (zh) 2017-02-16 2024-08-27 上海宜晟生物科技有限公司 采用纹理化表面的测定方法及装置
US12181472B2 (en) 2017-06-12 2024-12-31 Essenlix Corporation Homogeneous assay
CN111492222A (zh) 2017-08-01 2020-08-04 Essenlix公司 样品收集、保持和测定
US11725227B2 (en) 2017-08-01 2023-08-15 Essenlix Corporation Devices and methods for examining drug effects on microorganisms
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
WO2019075244A1 (fr) 2017-10-11 2019-04-18 Essenlix Corporation Contenant d'un échantillon liquide
WO2019075415A1 (fr) 2017-10-13 2019-04-18 Essenlix Corporation Dispositifs et procédés d'authentification d'analyse médicale et leurs utilisations
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
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Also Published As

Publication number Publication date
US20060078892A1 (en) 2006-04-13
CA2582462A1 (fr) 2006-04-27
AP2007003974A0 (en) 2007-06-30
JP2008516260A (ja) 2008-05-15
WO2006044459A2 (fr) 2006-04-27
EP1802322A4 (fr) 2009-07-22
JP4897689B2 (ja) 2012-03-14
MX2007004399A (es) 2007-04-25
AU2005295773B2 (en) 2011-06-09
EA200700847A1 (ru) 2007-10-26
NO20072427L (no) 2007-07-04
AU2005295773A1 (en) 2006-04-27
US7510848B2 (en) 2009-03-31
CN101065136A (zh) 2007-10-31
ZA200702634B (en) 2008-09-25
TNSN07136A1 (en) 2008-11-21
BRPI0515970A (pt) 2007-12-18
MA29004B1 (fr) 2007-11-01
EP1802322A2 (fr) 2007-07-04
KR20070117533A (ko) 2007-12-12
IL182422A0 (en) 2007-07-24
WO2006044459A3 (fr) 2006-07-13

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Effective date: 20171013