CA2584690C - Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif - Google Patents
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- CA2584690C CA2584690C CA2584690A CA2584690A CA2584690C CA 2584690 C CA2584690 C CA 2584690C CA 2584690 A CA2584690 A CA 2584690A CA 2584690 A CA2584690 A CA 2584690A CA 2584690 C CA2584690 C CA 2584690C
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- Gynecology & Obstetrics (AREA)
Abstract
L'invention concerne une nouvelle classe de peptides dérivés d'embryons (facteur de préimplantation) qui sont générés de manière synthétique et testés sur des cellules immunitaires sanguines périphériques et s'avèrent bloquer l'immunité activée mais non de base, inhibant la prolifération cellulaire et créant une sollicitation au moyen d'une cytokine de type T<SB>H</SB>2, de plus, ils renforcent la réceptivité de l'endomètre en augmentant l'expression des molécules d'adhésion. L'activité biologique de PIF s'exerce par liaison spécifique à des récepteurs inductibles présents sur plusieurs lignées de leucocytes. Les peptides PIF, qui sont des modulateurs immunitaires, peuvent donc avoir des applications de diagnostic et de thérapie non toxique au niveau de l'amélioration de la fertilité, réduisant ainsi les pertes de gestation; ils peuvent également servir lorsqu'ils sont administrés pour le traitement de maladies auto-immunes et la prévention de rejets de xénotransplants. En outre, les anticorps polyclonaux contre des peptides PIF sont créés et servent à mesurer avec précision des PIF dans des fluides biologiques. Ils documentent la présence et la viabilité de la gestation et contribuent à la surveillance des gestations à risque chez les humains ainsi que chez les animaux de ferme et non de ferme, à l'amélioration de l'élevage, où, actuellement, il n'existe aucun test de gestation spécifique. De plus, les anticorps PIF peuvent avoir d'autres propriétés thérapeutiques au niveau du traitement du VIH et du paludisme.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2894868A CA2894868C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51337003P | 2003-10-22 | 2003-10-22 | |
| US60/513,370 | 2003-10-22 | ||
| US48224403A | 2003-12-22 | 2003-12-22 | |
| US10/482,244 | 2004-08-11 | ||
| PCT/US2004/035382 WO2005040196A2 (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2894868A Division CA2894868C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2584690A1 CA2584690A1 (fr) | 2005-05-06 |
| CA2584690C true CA2584690C (fr) | 2015-10-06 |
Family
ID=34526220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2584690A Expired - Fee Related CA2584690C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Country Status (5)
| Country | Link |
|---|---|
| AU (1) | AU2004284097B2 (fr) |
| CA (1) | CA2584690C (fr) |
| IL (1) | IL175063A (fr) |
| NZ (1) | NZ547139A (fr) |
| WO (1) | WO2005040196A2 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8222211B2 (en) | 2001-07-02 | 2012-07-17 | Bioincept, Llc | Methods of administering PIF agonist peptides and uses thereof |
| US7273708B2 (en) | 2001-07-02 | 2007-09-25 | Bioincept, Llc | Assays for preimplantation factor and preimplantation factor peptides |
| US7723289B2 (en) * | 2003-10-22 | 2010-05-25 | Bioincept, Llc | PIF tetrapeptides |
| US7723290B2 (en) | 2004-10-22 | 2010-05-25 | Bioincept, Llc | Compositions and methods for modulating the immune system |
| US9737585B2 (en) | 2011-03-02 | 2017-08-22 | Bioincept, Llc | Compositions and methods for treatment of intracellular damage and bacterial infection |
| WO2017039751A1 (fr) | 2015-08-28 | 2017-03-09 | Bioincept, Llc | Peptides mutants et procédés de traitement de sujets les employant |
| EP2970496B1 (fr) | 2013-03-12 | 2018-07-18 | Institute of Arthritis Research LLC | Polypeptide actif d'un point de vue immunologique |
| EP3060924B1 (fr) * | 2013-10-22 | 2022-06-01 | Bioincept LLC | Cellules transfectées par un pif et procédés d'utilisation |
| US20170336406A1 (en) * | 2014-09-16 | 2017-11-23 | Bioincept, Llc | Pif binding as a marker for immune dysregulation |
| JP6806685B2 (ja) * | 2014-09-16 | 2021-01-06 | バイオインセプト、エルエルシー | 急性放射線症候群を治療するための組成物及び方法 |
| EP3341006A4 (fr) | 2015-08-28 | 2019-03-13 | BioIncept LLC | Compositions et méthodes pour le traitement d'une lésion neurologique |
| US20240293501A1 (en) * | 2020-06-18 | 2024-09-05 | Michael J. Paidas | Reagents, Pharmaceutical Formulations, and Methods for Treating and Preventing Viral Infection |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7273708B2 (en) | 2001-07-02 | 2007-09-25 | Bioincept, Llc | Assays for preimplantation factor and preimplantation factor peptides |
| WO2004053086A2 (fr) * | 2002-12-06 | 2004-06-24 | Epimmune, Inc. | Antigenes de plasmodium falciparum et procedes d'utilisation |
-
2004
- 2004-10-22 WO PCT/US2004/035382 patent/WO2005040196A2/fr not_active Ceased
- 2004-10-22 NZ NZ547139A patent/NZ547139A/en not_active IP Right Cessation
- 2004-10-22 CA CA2584690A patent/CA2584690C/fr not_active Expired - Fee Related
- 2004-10-22 AU AU2004284097A patent/AU2004284097B2/en not_active Ceased
-
2006
- 2006-04-20 IL IL175063A patent/IL175063A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL175063A (en) | 2011-10-31 |
| AU2004284097B2 (en) | 2011-05-12 |
| AU2004284097A1 (en) | 2005-05-06 |
| IL175063A0 (en) | 2006-08-20 |
| WO2005040196A3 (fr) | 2006-08-17 |
| NZ547139A (en) | 2009-12-24 |
| CA2584690A1 (fr) | 2005-05-06 |
| WO2005040196A2 (fr) | 2005-05-06 |
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