CA2588761C - 2,4(4,6)pyrimidine derivatives - Google Patents

2,4(4,6)pyrimidine derivatives Download PDF

Info

Publication number
CA2588761C
CA2588761C CA2588761A CA2588761A CA2588761C CA 2588761 C CA2588761 C CA 2588761C CA 2588761 A CA2588761 A CA 2588761A CA 2588761 A CA2588761 A CA 2588761A CA 2588761 C CA2588761 C CA 2588761C
Authority
CA
Canada
Prior art keywords
4alkyl
hydroxy
optionally substituted
2alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2588761A
Other languages
English (en)
French (fr)
Other versions
CA2588761A1 (en
Inventor
Eddy Jean Edgard Freyne
Marc Willems
Werner Constant Johan Embrechts
Kristof Van Emelen
Sven Franciscus Anna Van Brandt
Frederik Jan Rita Rombouts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA2588761A1 publication Critical patent/CA2588761A1/en
Application granted granted Critical
Publication of CA2588761C publication Critical patent/CA2588761C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
CA2588761A 2004-12-08 2005-12-08 2,4(4,6)pyrimidine derivatives Expired - Lifetime CA2588761C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63429104P 2004-12-08 2004-12-08
EP04106384.3 2004-12-08
EP04106384 2004-12-08
US60/634,291 2004-12-08
PCT/EP2005/056606 WO2006061415A1 (en) 2004-12-08 2005-12-08 2,4 (4,6) pyrimidine derivatives

Publications (2)

Publication Number Publication Date
CA2588761A1 CA2588761A1 (en) 2006-06-15
CA2588761C true CA2588761C (en) 2015-04-21

Family

ID=34930016

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2588761A Expired - Lifetime CA2588761C (en) 2004-12-08 2005-12-08 2,4(4,6)pyrimidine derivatives

Country Status (22)

Country Link
US (2) US8148388B2 (pt)
EP (1) EP1824856B1 (pt)
JP (1) JP5022909B2 (pt)
KR (1) KR101428506B1 (pt)
CN (1) CN101072779B (pt)
AR (1) AR051788A1 (pt)
AU (1) AU2005313348B2 (pt)
BR (1) BRPI0518424B8 (pt)
CA (1) CA2588761C (pt)
CR (1) CR9234A (pt)
DK (1) DK1824856T3 (pt)
EA (1) EA013368B1 (pt)
ES (1) ES2442458T3 (pt)
IL (1) IL183706A0 (pt)
MX (1) MX2007006821A (pt)
MY (1) MY169441A (pt)
NO (1) NO340130B1 (pt)
NZ (1) NZ554820A (pt)
TW (1) TWI374140B (pt)
UA (1) UA90693C2 (pt)
WO (1) WO2006061415A1 (pt)
ZA (1) ZA200705040B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA83881C2 (en) 2003-12-18 2008-08-26 Янссен Фармацевтика Н.В. Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
ES2442857T3 (es) * 2004-08-10 2014-02-13 Janssen Pharmaceutica Nv Derivados de 1,2,4-triazin-6-ona inhibidores de VIH
JO3088B1 (ar) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
NZ568325A (en) 2005-11-16 2011-05-27 S Bio Pte Ltd Macrocyclic oxygen linked pyrimidine derivatives
CA2654583C (en) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
WO2008060248A1 (en) * 2006-11-15 2008-05-22 S*Bio Pte Ltd. Indole sustituted pyrimidines and use thereof in the treatment of cancer
ES2562218T3 (es) 2007-07-27 2016-03-03 Janssen Pharmaceutica, N.V. Pirrolopirimidinas útiles para el tratamiento de enfermedades proliferativas
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
CN105367503A (zh) 2007-10-19 2016-03-02 阿维拉制药公司 杂芳基化合物和其用途
EP2283024B1 (en) 2008-03-10 2013-05-15 Janssen Pharmaceutica, N.V. 4-aryl-2-anilino-pyrimidines as plk kinase inhibitors
WO2009132202A2 (en) * 2008-04-24 2009-10-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8815872B2 (en) * 2008-09-08 2014-08-26 Merck Patent Gmbh Macrocyclics pyrimidines as aurora kinase inhibitors
US8765727B2 (en) 2009-01-23 2014-07-01 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
JP2012197231A (ja) * 2009-08-06 2012-10-18 Oncotherapy Science Ltd Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
US8927547B2 (en) 2010-05-21 2015-01-06 Noviga Research Ab Pyrimidine derivatives
MX382354B (es) 2010-11-01 2025-03-13 Celgene Car Llc Compuestos heterocíclicos y usos de los mismos.
US9133224B2 (en) * 2010-11-29 2015-09-15 OSI Pharmaceuticals, LLC Macrocyclic kinase inhibitors
DK2688883T3 (en) 2011-03-24 2016-09-05 Noviga Res Ab pyrimidine
PL2825042T3 (pl) 2012-03-15 2019-02-28 Celgene Car Llc Sole inhibitora kinazy receptora czynnika wzrostu naskórka
KR102081042B1 (ko) 2012-03-15 2020-02-26 셀젠 카르 엘엘씨 상피 성장 인자 수용체 키나제 억제제의 고체 형태
CN105164136B (zh) * 2013-05-06 2017-12-22 默克专利股份公司 作为激酶抑制剂的大环化合物
MA39823A (fr) 2014-04-03 2018-01-09 Janssen Pharmaceutica Nv Dérivés de pyridine macrocyclique
MA39822A (fr) * 2014-04-03 2018-02-06 Janssen Pharmaceutica Nv Dérivés de pyrimidine bicycle
EP3253764B1 (en) * 2015-02-05 2021-06-09 Merck Patent GmbH Macrocyclic compounds as irak1/4 inhibitors and uses thereof
EP3601253B1 (en) 2017-03-28 2021-09-15 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
CA3057891A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
WO2020249692A1 (en) * 2019-06-12 2020-12-17 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream
WO2020249689A1 (en) 2019-06-12 2020-12-17 Nouryon Chemicals International B.V. Process for the production of peroxyesters
ES2963382T3 (es) 2019-06-12 2024-03-26 Nouryon Chemicals Int Bv Proceso para la producción de peróxidos de diacilo
US11976035B2 (en) 2019-06-12 2024-05-07 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
EP3983369B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
KR20220153582A (ko) * 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
CN113549113A (zh) * 2020-06-17 2021-10-26 广州百霆医药科技有限公司 一种含膦大环化合物及其制备方法与应用
KR102613509B1 (ko) * 2021-12-15 2023-12-13 환인제약 주식회사 마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물
CA3250447A1 (en) * 2021-12-15 2025-07-09 Whan In Pharmaceutical Co., Ltd. MACROCYCLIC PYRIMIDINE DERIVATIVE, ITS PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITION INTENDED FOR THE PREVENTION OR TREATMENT OF A NEURODEGENERATIVE DISEASE AND CONTAINING THIS DERIVATIVE AS AN ACTIVE INGREDIENT

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2274634T3 (es) * 1998-08-29 2007-05-16 Astrazeneca Ab Compuestos de pirimidina.
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) * 2002-03-15 2002-05-01 Novartis Ag Organic compounds
ES2445208T3 (es) * 2002-07-29 2014-02-28 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
PA8603801A1 (es) 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
UA83881C2 (en) 2003-12-18 2008-08-26 Янссен Фармацевтика Н.В. Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
ATE446750T1 (de) 2003-12-18 2009-11-15 Janssen Pharmaceutica Nv 3-cyano-chinolin-derivate mit antiproliferativer wirkung

Also Published As

Publication number Publication date
CA2588761A1 (en) 2006-06-15
ZA200705040B (en) 2008-09-25
EA013368B1 (ru) 2010-04-30
BRPI0518424B1 (pt) 2020-10-13
AR051788A1 (es) 2007-02-07
CR9234A (es) 2008-09-09
UA90693C2 (en) 2010-05-25
BRPI0518424A2 (pt) 2008-11-25
CN101072779A (zh) 2007-11-14
EA200701245A1 (ru) 2007-12-28
KR101428506B1 (ko) 2014-08-12
US20120065395A1 (en) 2012-03-15
NO340130B1 (no) 2017-03-13
ES2442458T3 (es) 2014-02-11
IL183706A0 (en) 2007-09-20
HK1112455A1 (en) 2008-09-05
TWI374140B (en) 2012-10-11
AU2005313348A1 (en) 2006-06-15
MX2007006821A (es) 2007-07-24
CN101072779B (zh) 2010-12-22
KR20070085438A (ko) 2007-08-27
NO20073492L (no) 2007-07-09
JP5022909B2 (ja) 2012-09-12
BRPI0518424B8 (pt) 2021-05-25
WO2006061415A1 (en) 2006-06-15
NZ554820A (en) 2010-10-29
MY169441A (en) 2019-04-11
EP1824856A1 (en) 2007-08-29
US8394955B2 (en) 2013-03-12
JP2008523033A (ja) 2008-07-03
DK1824856T3 (da) 2014-01-27
TW200635931A (en) 2006-10-16
EP1824856B1 (en) 2013-10-23
US8148388B2 (en) 2012-04-03
AU2005313348B2 (en) 2011-10-06
US20100160310A1 (en) 2010-06-24

Similar Documents

Publication Publication Date Title
CA2588761C (en) 2,4(4,6)pyrimidine derivatives
AU2020343681B2 (en) Heterocyclic RIP1 kinase inhibitors
TWI804003B (zh) Tlr7/8拮抗劑及其用途
CA2611438C (en) Cyclic anilino-pyridinotriazines
CA2947338C (en) Multi-fluoro-substituted compound as bruton's tyrosine kinase (btk) inhibitor
JP2023529908A (ja) Ｂｒｍ標的化化合物及び関連する使用方法
JP2019508467A (ja) 癌治療用の２−シアノイソインドリン誘導体
EP2895174B1 (en) Prodrugs of amino quinazoline kinase inhibitor
KR20180095625A (ko) 신규한 화합물
BR122017002951A2 (pt) amidas heterocíclicas como inibidores de quinases
CN102985425A (zh) 作为蛋白酪氨酸激酶抑制剂的新的高哌嗪衍生物及其医药用途
KR20230122002A (ko) 이고리형 1,4-디아제판온 및 이의 치료적 용도
CA3199333A1 (en) C-myc mrna translation modulators and uses thereof in the treatment of cancer
CA3176635C (en) Bicyclic 1,4-diazepanones and therapeutic uses thereof
HK1212223B (en) Prodrugs of amino quinazoline kinase inhibitor

Legal Events

Date Code Title Description
EEER Examination request