MA39822A - Dérivés de pyrimidine bicycle - Google Patents
Dérivés de pyrimidine bicycleInfo
- Publication number
- MA39822A MA39822A MA039822A MA39822A MA39822A MA 39822 A MA39822 A MA 39822A MA 039822 A MA039822 A MA 039822A MA 39822 A MA39822 A MA 39822A MA 39822 A MA39822 A MA 39822A
- Authority
- MA
- Morocco
- Prior art keywords
- bicycle
- pyrimidine derivatives
- pyrimidine
- derivatives
- bicycle pyrimidine
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163443 | 2014-04-03 | ||
| EP14183747 | 2014-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39822A true MA39822A (fr) | 2018-02-06 |
Family
ID=52781117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA039822A MA39822A (fr) | 2014-04-03 | 2015-04-01 | Dérivés de pyrimidine bicycle |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10017509B2 (fr) |
| EP (1) | EP3126364B1 (fr) |
| JP (1) | JP6529513B2 (fr) |
| KR (1) | KR102390276B1 (fr) |
| CN (2) | CN106164075B (fr) |
| AU (1) | AU2015239098B2 (fr) |
| BR (1) | BR112016021982B1 (fr) |
| CA (1) | CA2942636C (fr) |
| CL (1) | CL2016002461A1 (fr) |
| EA (1) | EA031246B1 (fr) |
| ES (1) | ES2667723T3 (fr) |
| IL (1) | IL248005B (fr) |
| MA (1) | MA39822A (fr) |
| MX (1) | MX369798B (fr) |
| MY (1) | MY185491A (fr) |
| NZ (1) | NZ725399A (fr) |
| PE (1) | PE20161362A1 (fr) |
| PH (1) | PH12016501963B1 (fr) |
| SG (1) | SG11201608240RA (fr) |
| UA (1) | UA118219C2 (fr) |
| WO (1) | WO2015150555A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017219846B2 (en) | 2016-02-19 | 2021-05-13 | Sprint Bioscience Ab | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes |
| LT3416957T (lt) | 2016-02-19 | 2020-11-25 | Sprint Bioscience Ab | 6-heterociklil-4-morfolin-4-ilpiridin-2-ono junginiai, tinkami vėžio ir diabeto gydymui |
| ES2900199T3 (es) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novedosos compuestos macrocíclicos inhibidores de PTEFB |
| WO2018177889A1 (fr) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Nouveaux composés macrocycliques inhibiteurs de ptefb |
| IL302293A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds |
| CN116589461A (zh) | 2017-08-23 | 2023-08-15 | 思普瑞特生物科学公司 | 氮杂吲哚基吡啶酮化合物和二氮杂吲哚基吡啶酮化合物 |
| IL302077A (en) | 2017-08-23 | 2023-06-01 | Sprint Bioscience Ab | Morpholinylpyridone compounds |
| EP4056556A1 (fr) | 2017-08-23 | 2022-09-14 | Sprint Bioscience AB | Composés pyridylpyridone |
| MX2022010128A (es) * | 2020-02-18 | 2023-01-04 | Theseus Pharmaceuticals Inc | Compuestos macrocíclicos y usos de estos. |
| JP7784041B2 (ja) * | 2020-04-07 | 2025-12-11 | アイテオ ベルギウム エスエー | がんの治療のためのｅｎｔ阻害剤としての大環状ジアミン誘導体、及びそれとアデノシン受容体拮抗薬との組合せ |
| CN113735879B (zh) * | 2020-05-27 | 2022-05-17 | 百极弘烨（广东）医药科技有限公司 | 一种大环jak抑制剂及其应用 |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
| US20230271917A1 (en) * | 2020-07-22 | 2023-08-31 | Fog Pharmaceuticals, Inc. | Amino acids |
| CN118139846A (zh) * | 2021-09-23 | 2024-06-04 | 河南晟翔医药科技有限公司 | 一种egfr小分子抑制剂、含其的药物组合物及其用途 |
| KR102613509B1 (ko) * | 2021-12-15 | 2023-12-13 | 환인제약 주식회사 | 마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2024078263A1 (fr) * | 2022-10-09 | 2024-04-18 | 药雅科技(上海)有限公司 | Préparation et utilisation d'un composé hétérocyclique macrocyclique en tant qu'inhibiteur d'egfr |
| CN117229300A (zh) * | 2023-03-12 | 2023-12-15 | 药雅科技(上海)有限公司 | Egfr抑制剂的制备及其应用 |
| WO2024094171A1 (fr) * | 2022-11-04 | 2024-05-10 | 江苏恒瑞医药股份有限公司 | Composé aminopyrimidine substitué, son procédé de préparation et son utilisation médicale |
| CN116478076A (zh) * | 2023-04-26 | 2023-07-25 | 南京优氟医药科技有限公司 | 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078682A2 (fr) * | 2003-03-05 | 2004-09-16 | Irm Llc | Composes cycliques et compositions servant d'inhibiteurs de proteines-kinases |
| KR101109296B1 (ko) | 2003-03-24 | 2012-02-08 | 액시킨 파마수티컬스 인코포레이티드 | 천식 및 다른 염증성 또는 면역성 이상들의 치료용ｃｃｒ３ 길항 활성을 갖는 2-페녹시- 및2-페닐설폰아마이드 유도체 |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| EP1697384B1 (fr) | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Derives de pyrido- et pyrimidopyrimidine comme agents anti-proliferation |
| ES2335216T3 (es) | 2003-12-18 | 2010-03-23 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-quinolina con actividad antiproliferativa. |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| JO3088B1 (ar) | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| US8778919B2 (en) * | 2005-06-30 | 2014-07-15 | Janssen Pharmaceutica Nv | Cyclic anilino—pyridinotriazines |
| EP1951729B1 (fr) | 2005-11-16 | 2014-06-25 | Cell Therapeutics, Inc. | Derives de pyrimidine a liaison oxygene |
| WO2007059628A1 (fr) | 2005-11-24 | 2007-05-31 | Oz Communications Inc. | Procede destine a associer de façon securisee des donnees au moyen de sessions http et https |
| CA2687909C (fr) | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones et aza-indolin-2-ones |
| US8318731B2 (en) | 2007-07-27 | 2012-11-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| WO2009026197A1 (fr) | 2007-08-20 | 2009-02-26 | Glaxo Group Limited | Nouveaux inhibiteurs de la cathepsine c et leur utilisation |
| EP2283024B1 (fr) * | 2008-03-10 | 2013-05-15 | Janssen Pharmaceutica, N.V. | 4-aryl-2-anilino-pyrimidines comme inhibiteurs de plk kinases |
| KR20110031318A (ko) | 2008-06-13 | 2011-03-25 | 노파르티스 아게 | Ｉａ 심부전 및 암 치료에 유용한 단백질 키나제 ｄ 억제제로서의 2,4'-비피리디닐 화합물 |
| WO2010138666A1 (fr) | 2009-05-28 | 2010-12-02 | Tetralogic Pharmaceuticals Corp. | Inhibiteurs de protéines d'apoptose |
| CN102548987B (zh) | 2009-07-14 | 2014-04-16 | 江苏迈度药物研发有限公司 | 作为激酶抑制剂的氟取代化合物及其使用方法 |
| TWI513695B (zh) | 2009-10-27 | 2015-12-21 | Merck Sharp & Dohme | （１，１，１，３，３，３－六氟－２－羥基丙－２－基）苯基衍生物 |
-
2015
- 2015-04-01 MA MA039822A patent/MA39822A/fr unknown
- 2015-04-02 CA CA2942636A patent/CA2942636C/fr active Active
- 2015-04-02 US US15/300,956 patent/US10017509B2/en active Active
- 2015-04-02 CN CN201580018080.6A patent/CN106164075B/zh active Active
- 2015-04-02 AU AU2015239098A patent/AU2015239098B2/en not_active Ceased
- 2015-04-02 WO PCT/EP2015/057399 patent/WO2015150555A1/fr not_active Ceased
- 2015-04-02 CN CN202111600011.XA patent/CN114213415A/zh active Pending
- 2015-04-02 JP JP2016560825A patent/JP6529513B2/ja active Active
- 2015-04-02 MY MYPI2016001777A patent/MY185491A/en unknown
- 2015-04-02 ES ES15713522.9T patent/ES2667723T3/es active Active
- 2015-04-02 BR BR112016021982-1A patent/BR112016021982B1/pt not_active IP Right Cessation
- 2015-04-02 UA UAA201611005A patent/UA118219C2/uk unknown
- 2015-04-02 EP EP15713522.9A patent/EP3126364B1/fr active Active
- 2015-04-02 EA EA201692003A patent/EA031246B1/ru not_active IP Right Cessation
- 2015-04-02 KR KR1020167028764A patent/KR102390276B1/ko not_active Expired - Fee Related
- 2015-04-02 MX MX2016012992A patent/MX369798B/es active IP Right Grant
- 2015-04-02 NZ NZ725399A patent/NZ725399A/en unknown
- 2015-04-02 PE PE2016001882A patent/PE20161362A1/es unknown
- 2015-04-02 SG SG11201608240RA patent/SG11201608240RA/en unknown
-
2016
- 2016-09-25 IL IL248005A patent/IL248005B/en active IP Right Grant
- 2016-09-29 CL CL2016002461A patent/CL2016002461A1/es unknown
- 2016-10-03 PH PH12016501963A patent/PH12016501963B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20161362A1 (es) | 2016-12-17 |
| MY185491A (en) | 2021-05-19 |
| CA2942636A1 (fr) | 2015-10-08 |
| ES2667723T3 (es) | 2018-05-14 |
| KR20160142316A (ko) | 2016-12-12 |
| BR112016021982B1 (pt) | 2022-07-26 |
| CN106164075A (zh) | 2016-11-23 |
| BR112016021982A2 (fr) | 2017-08-15 |
| CL2016002461A1 (es) | 2017-06-23 |
| EA201692003A1 (ru) | 2017-06-30 |
| US10017509B2 (en) | 2018-07-10 |
| KR102390276B1 (ko) | 2022-04-22 |
| MX369798B (es) | 2019-11-21 |
| AU2015239098B2 (en) | 2019-08-01 |
| MX2016012992A (es) | 2016-12-07 |
| AU2015239098A1 (en) | 2016-09-29 |
| JP6529513B2 (ja) | 2019-06-12 |
| IL248005B (en) | 2018-12-31 |
| PH12016501963A1 (en) | 2017-01-09 |
| JP2017509687A (ja) | 2017-04-06 |
| US20170022202A1 (en) | 2017-01-26 |
| PH12016501963B1 (en) | 2017-01-09 |
| CA2942636C (fr) | 2023-03-21 |
| CN114213415A (zh) | 2022-03-22 |
| EP3126364A1 (fr) | 2017-02-08 |
| CN106164075B (zh) | 2021-11-26 |
| WO2015150555A1 (fr) | 2015-10-08 |
| EP3126364B1 (fr) | 2018-02-07 |
| SG11201608240RA (en) | 2016-10-28 |
| NZ725399A (en) | 2023-01-27 |
| UA118219C2 (uk) | 2018-12-10 |
| EA031246B1 (ru) | 2018-12-28 |
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