CA2603102C - Composes polyphenoliques protegeant l'elastine et methodes d'utilisation correspondantes - Google Patents

Composes polyphenoliques protegeant l'elastine et methodes d'utilisation correspondantes Download PDF

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Publication number
CA2603102C
CA2603102C CA2603102A CA2603102A CA2603102C CA 2603102 C CA2603102 C CA 2603102C CA 2603102 A CA2603102 A CA 2603102A CA 2603102 A CA2603102 A CA 2603102A CA 2603102 C CA2603102 C CA 2603102C
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CA
Canada
Prior art keywords
gly
pro
seq
elastin
val
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2603102A
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English (en)
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CA2603102A1 (fr
Inventor
Felipe Jimenez
Thomas Mitts
Aleksander Hinek
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Hospital for Sick Children
Human Matrix Sciences LLC
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Publication of CA2603102A1 publication Critical patent/CA2603102A1/fr
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Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Les fibroblastes dermiques perdent en permanence leur aptitude à synthétiser l'élastine qui représente l'élément principal des fibres élastiques, peu après la puberté. Cette perte progressive de fibres élastiques ne peut être remplacée, ce qui créent des signes physiques de vieillissement. La présente invention concerne des méthodes et des compositions contenant de l'acide ellagique et/ou de l'acide tannique de polyphénols permettant d'assurer une protection contre la dégradation des fibres élastiques de la peau par les enzymes élastolytiques. L'utilisation de l'acide ellagique et/ou de l'acide tannique permet d'augmenter le dépôt général des fibres élastiques dans des cellules cutanées endommagées et saines. La protection des fibres élastiques matures extracellulaires et intratropoélastines contre les enzymes protéolytiques au moyen de l'acide ellagique et de l'acide tannique permet d'obtenir une augmentation du dépôt net des fibres élastiques. Ainsi, les modes de réalisation décrits dans cette invention concernent des méthodes et des compositions permettant de traiter la peau et de prévenir et de traiter la détérioration des fibres élastiques dermiques.
CA2603102A 2005-03-29 2006-03-29 Composes polyphenoliques protegeant l'elastine et methodes d'utilisation correspondantes Expired - Lifetime CA2603102C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66596605P 2005-03-29 2005-03-29
US60/665,966 2005-03-29
US75882106P 2006-01-13 2006-01-13
US60/758,821 2006-01-13
PCT/US2006/012027 WO2007030145A2 (fr) 2005-03-29 2006-03-29 Composes polyphenoliques protegeant l'elastine et methodes d'utilisation correspondantes

Publications (2)

Publication Number Publication Date
CA2603102A1 CA2603102A1 (fr) 2007-03-15
CA2603102C true CA2603102C (fr) 2015-08-11

Family

ID=37836298

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2603102A Expired - Lifetime CA2603102C (fr) 2005-03-29 2006-03-29 Composes polyphenoliques protegeant l'elastine et methodes d'utilisation correspondantes

Country Status (3)

Country Link
EP (1) EP1874340A4 (fr)
CA (1) CA2603102C (fr)
WO (1) WO2007030145A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114829B2 (en) 2005-02-22 2012-02-14 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same
US8642578B2 (en) 2005-03-29 2014-02-04 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2611140B1 (fr) * 1987-02-20 1991-02-22 Lamaison Jean Louis Procede d'obtention de principes tanniques d'origine vegetale, composition cosmetologique et composition pharmaceutique contenant le principe tannique purifie obtenu selon le procede
JPS63313707A (ja) * 1987-06-16 1988-12-21 Seven Kagaku:Kk 皮膚化粧料
JP3393559B2 (ja) * 1993-10-15 2003-04-07 株式会社ノエビア 皮膚外用剤
FR2768927B1 (fr) * 1997-10-01 2000-01-21 Lvmh Rech Utilisation de l'acide ellagique, de ses sels, de ses complexes metalliques, de ses derives mono- ou poly-ethers, mono- ou poly-acyles dans le domaine de la cosmetique et de la pharmacie, notamment de la dermatologie
AU4229200A (en) * 1999-04-22 2000-11-10 Howard Murad Methods and compositions for treating dermatological disorders with fruit extracts
JP2001072571A (ja) * 1999-09-08 2001-03-21 Noevir Co Ltd 皮膚外用剤
EP1145709A1 (fr) * 2000-04-14 2001-10-17 Laboratoires Serobiologiques Utilisation de produits naturels pour préparer des compositions cosmétiques
JP2002205913A (ja) * 2001-01-10 2002-07-23 Ichimaru Pharcos Co Ltd 化粧料組成物
US20020127256A1 (en) * 2001-03-01 2002-09-12 Howard Murad Compositions and methods for treating dermatological disorders
ES2274842T3 (es) * 2001-08-18 2007-06-01 Cognis Ip Management Gmbh Mezclas de principios activos.
JP2003128511A (ja) * 2001-10-18 2003-05-08 Ichimaru Pharcos Co Ltd 皮膚老化防止剤
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
WO2004073616A2 (fr) * 2003-02-14 2004-09-02 Human Matrix Sciences Llc Compositions a base d'un produit de digestion d'elastine et leurs methodes d'utilisation
FR2854897B1 (fr) * 2003-05-12 2007-05-04 Sederma Sa Compositions cosmetiques ou dermopharmaceutiques pour reduire les signes du vieillissement cutane.
WO2005118783A1 (fr) * 2004-05-28 2005-12-15 Human Matrix Sciences, Llc Tests pronostiques pour le developpement de vergetures dermiques et leurs implications pour un traitement preventif associe
JP2006160685A (ja) * 2004-12-09 2006-06-22 Jc Community:Kk 経口用皮膚老化予防・改善剤
US7566693B2 (en) * 2005-02-22 2009-07-28 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same

Also Published As

Publication number Publication date
WO2007030145A3 (fr) 2009-04-16
CA2603102A1 (fr) 2007-03-15
WO2007030145A2 (fr) 2007-03-15
EP1874340A2 (fr) 2008-01-09
EP1874340A4 (fr) 2010-06-30

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