CA2617465A1 - Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive - Google Patents

Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive Download PDF

Info

Publication number: CA2617465A1
Authority: CA; Canada
Prior art keywords: approximately; platelet; supernatant; containers; sample
Prior art date: 2008-01-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002617465A

Other languages

English (en)

Inventor

Astley Smith

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-01-28

Filing date

2008-01-28

Publication date

2009-07-28

2008-01-28 Application filed by Individual filed Critical Individual

2008-01-28 Priority to CA002617465A priority Critical patent/CA2617465A1/fr

2009-07-28 Publication of CA2617465A1 publication Critical patent/CA2617465A1/fr

Status Abandoned legal-status Critical Current

Links

239000003634 thrombocyte concentrate Substances 0.000 title claims abstract description 24
238000000034 method Methods 0.000 title claims description 48
230000008569 process Effects 0.000 title description 10
239000006228 supernatant Substances 0.000 claims abstract description 82
238000005119 centrifugation Methods 0.000 claims abstract description 54
210000004369 blood Anatomy 0.000 claims abstract description 38
239000008280 blood Substances 0.000 claims abstract description 38
238000011176 pooling Methods 0.000 claims abstract description 25
238000009472 formulation Methods 0.000 claims abstract description 21
239000000203 mixture Substances 0.000 claims abstract description 21
238000004519 manufacturing process Methods 0.000 claims abstract description 9
210000004623 platelet-rich plasma Anatomy 0.000 claims description 32
239000002244 precipitate Substances 0.000 claims description 29
239000000725 suspension Substances 0.000 claims description 13
239000003146 anticoagulant agent Substances 0.000 claims description 8
229940127219 anticoagulant drug Drugs 0.000 claims description 8
230000029663 wound healing Effects 0.000 claims description 7
239000000047 product Substances 0.000 claims description 5
239000000515 collagen sponge Substances 0.000 claims description 3
230000000977 initiatory effect Effects 0.000 claims description 3
230000011164 ossification Effects 0.000 claims description 3
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
239000001509 sodium citrate Substances 0.000 claims description 2
230000003247 decreasing effect Effects 0.000 claims 2
230000001737 promoting effect Effects 0.000 claims 2
210000001772 blood platelet Anatomy 0.000 description 72
239000000523 sample Substances 0.000 description 21
239000008188 pellet Substances 0.000 description 16
230000015572 biosynthetic process Effects 0.000 description 7
230000010478 bone regeneration Effects 0.000 description 6
239000012141 concentrate Substances 0.000 description 6
210000002381 plasma Anatomy 0.000 description 6
238000001356 surgical procedure Methods 0.000 description 5
230000035876 healing Effects 0.000 description 4
239000000306 component Substances 0.000 description 3
230000001133 acceleration Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
239000000463 material Substances 0.000 description 2
239000013049 sediment Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
230000017423 tissue regeneration Effects 0.000 description 2
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
208000002847 Surgical Wound Diseases 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
239000012503 blood component Substances 0.000 description 1
230000032823 cell division Effects 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000002648 chondrogenic effect Effects 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000012468 concentrated sample Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000010908 decantation Methods 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
239000007943 implant Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000000278 osteoconductive effect Effects 0.000 description 1
230000002188 osteogenic effect Effects 0.000 description 1
230000002138 osteoinductive effect Effects 0.000 description 1
238000000596 photon cross correlation spectroscopy Methods 0.000 description 1
108010000685 platelet-derived growth factor AB Proteins 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3616—Blood, e.g. platelet-rich plasma
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Cell Biology (AREA)
Dermatology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Oral & Maxillofacial Surgery (AREA)
Developmental Biology & Embryology (AREA)
Transplantation (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Botany (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CA002617465A 2008-01-28 2008-01-28 Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive Abandoned CA2617465A1 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA002617465A CA2617465A1 (fr)	2008-01-28	2008-01-28	Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002617465A CA2617465A1 (fr)	2008-01-28	2008-01-28	Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive

Publications (1)

Publication Number	Publication Date
CA2617465A1 true CA2617465A1 (fr)	2009-07-28

Family

ID=40951314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002617465A Abandoned CA2617465A1 (fr)	2008-01-28	2008-01-28	Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive

Country Status (1)

Country	Link
CA (1)	CA2617465A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2264150A1 (fr) *	2009-06-09	2010-12-22	Astley E. Smith	Procédé de concentration de plaquettes à triple centrifugation, double mélange et redistribution et concentré plaquettaire ainsi dérivé
WO2017004606A1 (fr) *	2015-07-02	2017-01-05	Arthrex, Inc.	Procédés et dispositifs pour la préparation de fluides biologiques enrichis
US11904144B2 (en)	2019-10-04	2024-02-20	Arthrex, Inc.	Devices and methods for making therapeutic fluids

2008
- 2008-01-28 CA CA002617465A patent/CA2617465A1/fr not_active Abandoned

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2264150A1 (fr) *	2009-06-09	2010-12-22	Astley E. Smith	Procédé de concentration de plaquettes à triple centrifugation, double mélange et redistribution et concentré plaquettaire ainsi dérivé
WO2017004606A1 (fr) *	2015-07-02	2017-01-05	Arthrex, Inc.	Procédés et dispositifs pour la préparation de fluides biologiques enrichis
IL256487A (en) *	2015-07-02	2018-02-28	Arthrex Inc	Methods and apparatus for making enriched biological fluids
JP2018528929A (ja) *	2015-07-02	2018-10-04	アースレックスインコーポレイテッド	富化体液の調製のための方法および装置
US10512659B2 (en)	2015-07-02	2019-12-24	Arthrex, Inc.	Methods and devices for preparation of enriched biological fluids
AU2016287606B2 (en) *	2015-07-02	2020-11-26	Arthrex, Inc.	Methods and devices for preparation of enriched biological fluids
US11904144B2 (en)	2019-10-04	2024-02-20	Arthrex, Inc.	Devices and methods for making therapeutic fluids

Legal Events

Date	Code	Title	Description
2013-03-25	FZDE	Dead	Effective date: 20130128

Publication	Publication Date	Title
US6398972B1 (en)	2002-06-04	Method for producing platelet rich plasma and/or platelet concentrate
US20020104808A1 (en)	2002-08-08	Method and apparatus for producing platelet rich plasma and/or platelet concentrate
Croisé et al.	2020	Optimized centrifugation preparation of the platelet rich plasma: Literature review
Nagata et al.	2010	Effectiveness of two methods for preparation of autologous platelet-rich plasma: an experimental study in rabbits
EP1066838B1 (fr)	2008-05-21	Composition pour la regeneration des tissus osseux
EP2806914B1 (fr)	2021-09-22	Système et procédé pour l'obtention d'un échantillon cellulaire enrichi en cellules précises tel que le plasma riche en plaquettes (prp)
US20030094425A1 (en)	2003-05-22	Blood processing system and composition
CN104307208B (zh)	2016-08-24	一种富集纯化血小板的方法
US20140241957A1 (en)	2014-08-28	Tube to produce platelet rich fibrin
CN107446036A (zh)	2017-12-08	一种血小板细胞因子浓集物的富集方法
US20090202981A1 (en)	2009-08-13	Triple spin, double pool and revolumization process for concentrating platelets and derivative platelet concentrate
CA2617465A1 (fr)	2009-07-28	Methode de concentration des plaquettes a triple rotation, a double melange et a nouvelle volumisation, et concentre de plaquettes derive
US20160100912A1 (en)	2016-04-14	Methods, inserts, and systems useful for endodontic treatment
RU2428995C1 (ru)	2011-09-20	Способ получения аутологичного тромбоцитарного геля
EP2264150A1 (fr)	2010-12-22	Procédé de concentration de plaquettes à triple centrifugation, double mélange et redistribution et concentré plaquettaire ainsi dérivé
RU2410127C1 (ru)	2011-01-27	Способ получения аутогенной активированной обогащенной тромбоцитами плазмы для стоматологии
JP2001520198A (ja)	2001-10-30	血小板富有血漿からの成長因子富有化フィブリノーゲン濃縮物の調製
TWI736824B (zh)	2021-08-21	分離血液的方法
CN110538196A (zh)	2019-12-06	一种富血小板血浆和提取富血小板血浆的方法
Sood et al.	2012	Platelet Concentrates-Part I.
Mansour et al.	2010	Use of concentrated growth factor (CGF) in implantology
TWM618792U (zh)	2021-11-01	高濃度血小板血漿分離套組
Astuti et al.	2018	Effect of Centrifugation speed and duration of the quantity of platelet rich plasma (PRP)
US20140107699A1 (en)	2014-04-17	Active loaded fixation devices
Singh	2022	Role of Platelet-Rich Fibrin In Oral And Maxillofacial Surgery