CA2618084A1 - Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine - Google Patents

Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine Download PDF

Info

Publication number: CA2618084A1
Authority: CA; Canada
Prior art keywords: pharmaceutical composition; cancer; oil; fatty acid; composition according
Prior art date: 2005-08-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002618084A

Other languages

English (en)

Inventor

Isabel Ottinger

Oskar Kalb

Walter Stebler

Agnes Taillardat

Wolfgang Wirth

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-10

Filing date

2006-08-08

Publication date

2007-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37056484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2618084(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-08 Application filed by Individual filed Critical Individual

2007-02-15 Publication of CA2618084A1 publication Critical patent/CA2618084A1/fr

Status Abandoned legal-status Critical Current

Links

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BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
229920001664 tyloxapol Polymers 0.000 description 1
MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
229960004224 tyloxapol Drugs 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000001238 wet grinding Methods 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000002888 zwitterionic surfactant Substances 0.000 description 1
DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002618084A 2005-08-10 2006-08-08 Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine Abandoned CA2618084A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US70713905P	2005-08-10	2005-08-10
US60/707,139		2005-08-10
PCT/EP2006/065160 WO2007017514A1 (fr)	2005-08-10	2006-08-08	Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine

Publications (1)

Publication Number	Publication Date
CA2618084A1 true CA2618084A1 (fr)	2007-02-15

Family

ID=37056484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002618084A Abandoned CA2618084A1 (fr)	2005-08-10	2006-08-08	Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine

Country Status (20)

Country	Link
EP (1)	EP1915132A1 (fr)
JP (1)	JP2009504616A (fr)
KR (1)	KR20080034989A (fr)
CN (1)	CN101287448A (fr)
AR (1)	AR055602A1 (fr)
AU (1)	AU2006277879A1 (fr)
BR (1)	BRPI0614757A2 (fr)
CA (1)	CA2618084A1 (fr)
EC (1)	ECSP088166A (fr)
GT (1)	GT200600364A (fr)
IL (1)	IL189076A0 (fr)
MA (1)	MA29735B1 (fr)
MX (1)	MX2008001965A (fr)
NO (1)	NO20081213L (fr)
PE (1)	PE20070232A1 (fr)
RU (1)	RU2008108885A (fr)
TN (1)	TNSN08062A1 (fr)
TW (1)	TW200800195A (fr)
WO (1)	WO2007017514A1 (fr)
ZA (1)	ZA200800726B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2025186213A1 (fr)	2024-03-04	2025-09-12	Debiopharm International S.A.	Combinaison d'un inhibiteur de wee1 et d'un inhibiteur de topoisomérase 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5145684A (en) *	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
US5726181A (en) *	1995-06-05	1998-03-10	Bionumerik Pharmaceuticals, Inc.	Formulations and compositions of poorly water soluble camptothecin derivatives
US7374779B2 (en) *	1999-02-26	2008-05-20	Lipocine, Inc.	Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
IT1306129B1 (it) *	1999-04-13	2001-05-30	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
EP1269994A3 (fr) *	2001-06-22	2003-02-12	Pfizer Products Inc.	Compositions Pharmaceutiques comprenant un médicament et un polymère permettant d'améliorer la concentration du médicament
GT200500310A (es) *	2004-11-19	2006-06-19		Compuestos organicos

2006
- 2006-08-08 EP EP06792739A patent/EP1915132A1/fr not_active Withdrawn
- 2006-08-08 JP JP2008525580A patent/JP2009504616A/ja active Pending
- 2006-08-08 AR ARP060103450A patent/AR055602A1/es not_active Application Discontinuation
- 2006-08-08 PE PE2006000965A patent/PE20070232A1/es not_active Application Discontinuation
- 2006-08-08 CA CA002618084A patent/CA2618084A1/fr not_active Abandoned
- 2006-08-08 GT GT200600364A patent/GT200600364A/es unknown
- 2006-08-08 MX MX2008001965A patent/MX2008001965A/es not_active Application Discontinuation
- 2006-08-08 TW TW095129044A patent/TW200800195A/zh unknown
- 2006-08-08 KR KR1020087005632A patent/KR20080034989A/ko not_active Withdrawn
- 2006-08-08 CN CNA200680037599XA patent/CN101287448A/zh active Pending
- 2006-08-08 RU RU2008108885/15A patent/RU2008108885A/ru not_active Application Discontinuation
- 2006-08-08 WO PCT/EP2006/065160 patent/WO2007017514A1/fr not_active Ceased
- 2006-08-08 AU AU2006277879A patent/AU2006277879A1/en not_active Abandoned
- 2006-08-08 BR BRPI0614757-7A patent/BRPI0614757A2/pt not_active IP Right Cessation
2008
- 2008-01-24 ZA ZA200800726A patent/ZA200800726B/xx unknown
- 2008-01-28 IL IL189076A patent/IL189076A0/en unknown
- 2008-02-08 MA MA30631A patent/MA29735B1/fr unknown
- 2008-02-08 TN TNP2008000062A patent/TNSN08062A1/en unknown
- 2008-02-08 EC EC2008008166A patent/ECSP088166A/es unknown
- 2008-03-07 NO NO20081213A patent/NO20081213L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
GT200600364A (es)	2007-03-19
ZA200800726B (en)	2009-08-26
NO20081213L (no)	2008-05-13
AR055602A1 (es)	2007-08-29
TW200800195A (en)	2008-01-01
KR20080034989A (ko)	2008-04-22
CN101287448A (zh)	2008-10-15
PE20070232A1 (es)	2007-04-09
ECSP088166A (es)	2008-03-26
BRPI0614757A2 (pt)	2011-04-12
WO2007017514A1 (fr)	2007-02-15
MA29735B1 (fr)	2008-09-01
AU2006277879A1 (en)	2007-02-15
IL189076A0 (en)	2008-08-07
TNSN08062A1 (en)	2009-07-14
JP2009504616A (ja)	2009-02-05
MX2008001965A (es)	2008-03-26
EP1915132A1 (fr)	2008-04-30
RU2008108885A (ru)	2009-09-20

Legal Events

Date	Code	Title	Description
2011-08-08	FZDE	Discontinued

Publication	Publication Date	Title
RU2620331C2 (ru)	2017-05-24	Фармацевтические композиции, включающие производное камптотецина
CA2362277C (fr)	2010-03-30	Compositions spontanement dispersibles de n-benzoyl staurosporine
KR101928589B1 (ko)	2018-12-12	알리스포리비르를 포함하는 제약 조성물
US20080279940A1 (en)	2008-11-13	Microemulsions of Cannabinoid Receptor Binding Compounds
EP1715848B1 (fr)	2010-07-28	Formulations sous forme de micro-emulsion renfermant certains antagonistes de la substance p
CA2618084A1 (fr)	2007-02-15	Compositions de microparticules contenant un inhibiteur de la topoisomerase 1, la 7-tert-butoxyiminomethylcamptothecine
US20100068265A1 (en)	2010-03-18	Gelatin capsules comprising an acid
KR20070018003A (ko)	2007-02-13	특정 물질 ｐ 길항제를 포함하는 마이크로에멀젼 제제
HK1186658B (en)	2018-03-23	Pharmaceutical compositions comprising alisporivir
HK1186658A (en)	2014-03-21	Pharmaceutical compositions comprising alisporivir