CA2618513A1 - Unsaturated heterocyclic derivatives - Google Patents

Unsaturated heterocyclic derivatives Download PDF

Info

Publication number: CA2618513A1
Authority: CA; Canada
Prior art keywords: compound; heteroaryl; purin; aryl; moiety
Prior art date: 2005-08-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002618513A

Other languages

English (en)

French (fr)

Inventor

Yihan Wang

Wei-Sheng Huang

Rajeswari Sundaramoorthi

Xiaotian Zhu

R. Mathew Thomas

William C. Shakespeare

David C. Dalgarno

Tomi K. Sawyer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ariad Pharmaceuticals Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-11

Filing date

2006-08-11

Publication date

2007-02-22

2006-08-11 Application filed by Individual filed Critical Individual

2007-02-22 Publication of CA2618513A1 publication Critical patent/CA2618513A1/en

Status Abandoned legal-status Critical Current

Links

125000000623 heterocyclic group Chemical group 0.000 title claims description 37
150000001875 compounds Chemical class 0.000 claims abstract description 301
-1 heteroaliphatic Chemical group 0.000 claims description 141
239000000203 mixture Substances 0.000 claims description 79
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125000003118 aryl group Chemical group 0.000 claims description 51
125000001072 heteroaryl group Chemical group 0.000 claims description 50
238000000034 method Methods 0.000 claims description 34
108091000080 Phosphotransferase Proteins 0.000 claims description 32
102000020233 phosphotransferase Human genes 0.000 claims description 32
125000001424 substituent group Chemical group 0.000 claims description 32
238000011282 treatment Methods 0.000 claims description 28
125000001931 aliphatic group Chemical group 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 24
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 21
208000032839 leukemia Diseases 0.000 claims description 17
201000010099 disease Diseases 0.000 claims description 14
229910052736 halogen Inorganic materials 0.000 claims description 14
150000002367 halogens Chemical class 0.000 claims description 13
125000004122 cyclic group Chemical group 0.000 claims description 12
229910052739 hydrogen Inorganic materials 0.000 claims description 11
229910052799 carbon Inorganic materials 0.000 claims description 10
239000001257 hydrogen Substances 0.000 claims description 9
229910052720 vanadium Inorganic materials 0.000 claims description 9
241001465754 Metazoa Species 0.000 claims description 8
125000005843 halogen group Chemical group 0.000 claims description 8
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
230000002401 inhibitory effect Effects 0.000 claims description 7
230000001404 mediated effect Effects 0.000 claims description 7
150000002431 hydrogen Chemical group 0.000 claims description 6
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
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Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
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Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
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Animal Behavior & Ethology (AREA)
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CA002618513A 2005-08-11 2006-08-11 Unsaturated heterocyclic derivatives Abandoned CA2618513A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US70742305P	2005-08-11	2005-08-11
US60/707,423		2005-08-11
PCT/US2006/031382 WO2007021937A2 (en)	2005-08-11	2006-08-11	Unsaturated heterocyclic derivatives

Publications (1)

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CA2618513A1 true CA2618513A1 (en)	2007-02-22

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CA002618513A Abandoned CA2618513A1 (en)	2005-08-11	2006-08-11	Unsaturated heterocyclic derivatives

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US (2)	US8071609B2 (2)
EP (1)	EP1940843A4 (2)
JP (1)	JP5321061B2 (2)
CA (1)	CA2618513A1 (2)
WO (1)	WO2007021937A2 (2)

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2006
- 2006-08-11 JP JP2008526231A patent/JP5321061B2/ja active Active
- 2006-08-11 US US11/990,299 patent/US8071609B2/en active Active
- 2006-08-11 CA CA002618513A patent/CA2618513A1/en not_active Abandoned
- 2006-08-11 WO PCT/US2006/031382 patent/WO2007021937A2/en not_active Ceased
- 2006-08-11 EP EP20060813381 patent/EP1940843A4/en not_active Withdrawn
2011
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JP2009505980A (ja)	2009-02-12
US20120178716A1 (en)	2012-07-12
EP1940843A2 (en)	2008-07-09
US8586566B2 (en)	2013-11-19
WO2007021937A3 (en)	2007-07-12
WO2007021937A2 (en)	2007-02-22
EP1940843A4 (en)	2010-09-15
US8071609B2 (en)	2011-12-06
JP5321061B2 (ja)	2013-10-23
US20090156596A1 (en)	2009-06-18

Legal Events

Date	Code	Title	Description
2011-07-22	EEER	Examination request
2014-04-17	FZDE	Discontinued	Effective date: 20140220

Publication	Publication Date	Title
US8586566B2 (en)	2013-11-19	Unsaturated heterocyclic derivatives
US20250361232A1 (en)	2025-11-27	Substituted acetylenic pyrazolo[1,5-a]pyridine compounds as kinase inhibitors
US8461167B2 (en)	2013-06-11	Acetylenic heteroaryl compounds
EP2024366B1 (en)	2015-09-16	Monocyclic heteroaryl compounds
US20050065171A1 (en)	2005-03-24	Substituted purine derivatives
HK40000059A (en)	2020-01-31	Bicyclic heteroaryl compounds