JP5321061B2 - 不飽和複素環誘導体 - Google Patents

不飽和複素環誘導体 Download PDF

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Publication number: JP5321061B2
Authority: JP; Japan
Prior art keywords: purin; phenyl; dimethylphosphoryl; amine; methyl
Prior art date: 2005-08-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2008526231A

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English (en)

Japanese (ja)

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JP2009505980A (ja

JP2009505980A5 (2

Inventor

ワン、イーハン

ホワン、ウェイ−シェン

サンダラムールティ、ラジェスワリ

チュー、シュエチァン

トーマス、アール・マシュー

シェークスピア、ウィリアム・シー

ダルガーノ、ディビッド・シー

ソーヤー、トミー・ケー

Original Assignee

アリアド・ファーマシューティカルズ・インコーポレイテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-11

Filing date

2006-08-11

Publication date

2013-10-23

2006-08-11 Application filed by アリアド・ファーマシューティカルズ・インコーポレイテッド filed Critical アリアド・ファーマシューティカルズ・インコーポレイテッド

2009-02-12 Publication of JP2009505980A publication Critical patent/JP2009505980A/ja

2009-09-24 Publication of JP2009505980A5 publication Critical patent/JP2009505980A5/ja

2013-10-23 Application granted granted Critical

2013-10-23 Publication of JP5321061B2 publication Critical patent/JP5321061B2/ja

Status Active legal-status Critical Current

2026-08-11 Anticipated expiration legal-status Critical

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0 CC(*)*(*CC(C)CO)C1(*)N[C@@]1(C)* Chemical compound CC(*)*(*CC(C)CO)C1(*)N[C@@]1(C)* 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Obesity (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

JP2008526231A 2005-08-11 2006-08-11 不飽和複素環誘導体 Active JP5321061B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US70742305P	2005-08-11	2005-08-11
US60/707,423		2005-08-11
PCT/US2006/031382 WO2007021937A2 (en)	2005-08-11	2006-08-11	Unsaturated heterocyclic derivatives

Publications (3)

Publication Number	Publication Date
JP2009505980A JP2009505980A (ja)	2009-02-12
JP2009505980A5 JP2009505980A5 (2)	2009-09-24
JP5321061B2 true JP5321061B2 (ja)	2013-10-23

Family

ID=37758204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2008526231A Active JP5321061B2 (ja)	2005-08-11	2006-08-11	不飽和複素環誘導体

Country Status (5)

Country	Link
US (2)	US8071609B2 (2)
EP (1)	EP1940843A4 (2)
JP (1)	JP5321061B2 (2)
CA (1)	CA2618513A1 (2)
WO (1)	WO2007021937A2 (2)

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* Cited by examiner, † Cited by third party
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EP2543376A1 (en)	2004-04-08	2013-01-09	Targegen, Inc.	Benzotriazine inhibitors of kinases
US7652051B2 (en)	2004-08-25	2010-01-26	Targegen, Inc.	Heterocyclic compounds and methods of use
JP5321061B2 (ja)	2005-08-11	2013-10-23	アリアド・ファーマシューティカルズ・インコーポレイテッド	不飽和複素環誘導体
EA034598B1 (ru)	2005-12-23	2020-02-25	Ариад Фармасьютикалз, Инк.	Применение бициклических гетероарильных соединений для лечения рака
ES2385404T3 (es) *	2006-04-14	2012-07-24	Abbott Laboratories	Procedimiento para la preparación de ureas de indazolilo que inhiben los receptores vaniloides de subtipo 1 (VR1)
AU2013203928B2 (en) *	2006-05-08	2015-07-16	Ariad Pharmaceuticals, Inc.	Monocyclic heteroaryl compounds
CN103435595A (zh)	2006-05-08	2013-12-11	阿里亚德医药股份有限公司	炔类杂芳基化合物
US8278307B2 (en) *	2006-05-08	2012-10-02	Ariad Pharmaceuticals, Inc.	Monocyclic Heteroaryl compounds
CN101489558A (zh) *	2006-05-08	2009-07-22	阿里亚德医药股份有限公司	炔类杂芳基化合物
EP2209786B1 (en)	2007-10-05	2013-02-27	Verastem, Inc.	Pyrimidine substituted purine derivatives
MX353308B (es) *	2008-05-21	2018-01-08	Ariad Pharma Inc	Derivados fosforosos como inhibidores de cinasa.
US9273077B2 (en)	2008-05-21	2016-03-01	Ariad Pharmaceuticals, Inc.	Phosphorus derivatives as kinase inhibitors
CA2743449C (en)	2008-11-12	2016-10-18	Ariad Pharmaceuticals, Inc.	Pyrazinopyrazines and derivatives as kinase inhibitors
WO2010114484A1 (en)	2009-04-03	2010-10-07	S*Bio Pte Ltd	Pyrimidine substituted purine compounds as kinase (s) inhibitors
TW201100441A (en)	2009-06-01	2011-01-01	Osi Pharm Inc	Amino pyrimidine anticancer compounds
EP2646448B1 (en)	2010-11-29	2017-08-30	OSI Pharmaceuticals, LLC	Macrocyclic kinase inhibitors
EP2704572B1 (en)	2011-05-04	2015-12-30	Ariad Pharmaceuticals, Inc.	Compounds for inhibiting cell proliferation in egfr-driven cancers
JP6182593B2 (ja) *	2012-04-20	2017-08-16	アドヴィーナスセラピューティクスリミテッド	置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途
WO2013169401A1 (en)	2012-05-05	2013-11-14	Ariad Pharmaceuticals, Inc.	Compounds for inhibiting cell proliferation in egfr-driven cancers
CA3022250A1 (en)	2012-12-12	2014-06-12	Ariad Pharmaceuticals, Inc.	Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
US9611283B1 (en)	2013-04-10	2017-04-04	Ariad Pharmaceuticals, Inc.	Methods for inhibiting cell proliferation in ALK-driven cancers
BR112016017993A2 (pt)	2014-02-03	2017-08-08	Quadriga Biosciences Inc	Gama-aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos
WO2015117147A1 (en)	2014-02-03	2015-08-06	Quadriga Biosciences, Inc.	Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
KR20180035894A (ko)	2015-08-03	2018-04-06	콰드리가 바이오사이언시스 인코포레이티드	화학치료제로서의 베타-치환된 베타-아미노산 및 유사체 및 이들의 용도
WO2018224455A1 (en)	2017-06-07	2018-12-13	Basf Se	Substituted cyclopropyl derivatives
ES2960987T3 (es)	2019-04-12	2024-03-07	Riboscience Llc	Derivados de heteroarilo bicíclicos como inhibidores de la ectonucleótido pirofosfatasa fosfodiesterasa 1
CN114292269B (zh) *	2021-12-21	2024-03-29	南昌大学	一种邻氨基嘌呤苯甲酰胺类衍生物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
GB9903762D0 (en) *	1999-02-18	1999-04-14	Novartis Ag	Organic compounds
ATE327242T1 (de) *	1999-12-17	2006-06-15	Ariad Pharma Inc	Neue purine
WO2002096933A1 (en)	2001-05-30	2002-12-05	Novartis Ag	2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives
US6770652B2 (en) *	2001-10-18	2004-08-03	Duquesne University Of The Holy Ghost	Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same
WO2003087087A2 (en) *	2002-04-09	2003-10-23	Astex Technology Limited	Heterocyclic compounds and their use as modulators of p38 map kinase
WO2004021979A2 (en) *	2002-09-06	2004-03-18	Smithkline Beecham Corporation	PYRROLO[2, 3-d]PYRIMIDINE-4-YL AND PURIN-6-YL UREA COMPOUNDS
US20050054614A1 (en)	2003-08-14	2005-03-10	Diacovo Thomas G.	Methods of inhibiting leukocyte accumulation
JP5321061B2 (ja)	2005-08-11	2013-10-23	アリアド・ファーマシューティカルズ・インコーポレイテッド	不飽和複素環誘導体
EA034598B1 (ru)	2005-12-23	2020-02-25	Ариад Фармасьютикалз, Инк.	Применение бициклических гетероарильных соединений для лечения рака
US8278307B2 (en)	2006-05-08	2012-10-02	Ariad Pharmaceuticals, Inc.	Monocyclic Heteroaryl compounds
EP2107054A1 (en)	2008-04-01	2009-10-07	Università Degli Studi Di Milano - Bicocca	Antiproliferative compounds and therapeutic uses thereof

2006
- 2006-08-11 JP JP2008526231A patent/JP5321061B2/ja active Active
- 2006-08-11 US US11/990,299 patent/US8071609B2/en active Active
- 2006-08-11 CA CA002618513A patent/CA2618513A1/en not_active Abandoned
- 2006-08-11 WO PCT/US2006/031382 patent/WO2007021937A2/en not_active Ceased
- 2006-08-11 EP EP20060813381 patent/EP1940843A4/en not_active Withdrawn
2011
- 2011-12-05 US US13/311,106 patent/US8586566B2/en active Active

Also Published As

Publication number	Publication date
JP2009505980A (ja)	2009-02-12
US20120178716A1 (en)	2012-07-12
EP1940843A2 (en)	2008-07-09
US8586566B2 (en)	2013-11-19
WO2007021937A3 (en)	2007-07-12
WO2007021937A2 (en)	2007-02-22
CA2618513A1 (en)	2007-02-22
EP1940843A4 (en)	2010-09-15
US8071609B2 (en)	2011-12-06
US20090156596A1 (en)	2009-06-18

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Publication	Publication Date	Title
JP5321061B2 (ja)	2013-10-23	不飽和複素環誘導体
JP6604739B2 (ja)	2019-11-13	二環式ヘテロアリール化合物
JP5273037B2 (ja)	2013-08-28	アセチレン性ヘテロアリール化合物
JP5273038B2 (ja)	2013-08-28	単環式ヘテロアリール化合物
CN101490053B (zh)	2013-09-11	单环杂芳基化合物
US20050065171A1 (en)	2005-03-24	Substituted purine derivatives