CA2643785A1 - Extracts and methods comprising ganoderma species - Google Patents

Extracts and methods comprising ganoderma species Download PDF

Info

Publication number: CA2643785A1
Authority: CA; Canada
Prior art keywords: acid; weight; ganoderma species; ganoderma; extract
Prior art date: 2006-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002643785A

Other languages

English (en)

French (fr)

Inventor

Robert T. Gow

Dan Li

George W. Sypert

Randall S. Alberte

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

HerbalScience Singapore Pte Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-23

Filing date

2007-03-23

Publication date

2007-09-27

2007-03-23 Application filed by Individual filed Critical Individual

2007-09-27 Publication of CA2643785A1 publication Critical patent/CA2643785A1/en

Status Abandoned legal-status Critical Current

Links

241000222336 Ganoderma Species 0.000 title claims abstract description 253
239000000284 extract Substances 0.000 title claims abstract description 114
238000000034 method Methods 0.000 title claims description 119
238000000605 extraction Methods 0.000 claims abstract description 186
239000000463 material Substances 0.000 claims abstract description 68
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 164
239000000341 volatile oil Substances 0.000 claims description 136
229920001282 polysaccharide Polymers 0.000 claims description 110
239000005017 polysaccharide Substances 0.000 claims description 110
239000000126 substance Substances 0.000 claims description 106
150000003648 triterpenes Chemical class 0.000 claims description 104
150000004676 glycans Chemical class 0.000 claims description 103
239000000470 constituent Substances 0.000 claims description 88
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 58
YCXUCEXEMJPDRZ-QWPKPZHNSA-N (2r,6s)-6-[(3s,5r,10s,12s,13r,14r,17r)-12-acetyloxy-3-hydroxy-4,4,10,13,14-pentamethyl-7,11,15-trioxo-1,2,3,5,6,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC(=O)C1=C2C(=O)[C@@H](OC(C)=O)[C@]2(C)[C@@H]([C@H](CC(=O)C[C@@H](C)C(O)=O)C)CC(=O)[C@]21C YCXUCEXEMJPDRZ-QWPKPZHNSA-N 0.000 claims description 57
MDZGCORLSWTNDB-DMSHPXPKSA-N Ganoderic acid H Natural products C[C@H](CC=O)CC(=O)C[C@@H](C)[C@H]1CC(=O)[C@@]2(C)C3=C(C(=O)[C@@H](OC(=O)C)[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC3=O MDZGCORLSWTNDB-DMSHPXPKSA-N 0.000 claims description 57
150000001875 compounds Chemical class 0.000 claims description 54
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical group ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 49
239000000243 solution Substances 0.000 claims description 46
239000002904 solvent Substances 0.000 claims description 36
238000000375 direct analysis in real time Methods 0.000 claims description 35
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 28
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 24
RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 claims description 24
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 24
DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 claims description 24
DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 claims description 24
229910002092 carbon dioxide Inorganic materials 0.000 claims description 22
230000008569 process Effects 0.000 claims description 20
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 19
239000002253 acid Substances 0.000 claims description 19
RDMQPKIDHAFXKA-JNORPAGFSA-N Ganoderic Acid Am1 Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC(=O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)CC(C)C(O)=O)C)CC(=O)[C@]21C RDMQPKIDHAFXKA-JNORPAGFSA-N 0.000 claims description 14
YPYHGMCHNBTMDB-GOGDEKJESA-N Ganolucidic acid B Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)CC(C)C(O)=O)C)C[C@H](O)[C@]21C YPYHGMCHNBTMDB-GOGDEKJESA-N 0.000 claims description 14
SWCVYBRFEIGTQI-KLRWDABWSA-N Ganolucidic acid B Natural products C[C@H](CC=O)CC(=O)C[C@@H](C)[C@H]1C[C@H](O)[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC3 SWCVYBRFEIGTQI-KLRWDABWSA-N 0.000 claims description 14
GOQYKNQRPGWPLP-UHFFFAOYSA-N heptadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 13
BPJPBLZKOVIJQD-UHFFFAOYSA-N (3beta,7beta,12beta)-3,7,12-Trihydroxy-11,15,23-trioxolanost-8-en-26-oic acid Natural products CC12CCC(O)C(C)(C)C1CC(O)C1=C2C(=O)C(O)C2(C)C(C(CC(=O)CC(C)C(O)=O)C)CC(=O)C21C BPJPBLZKOVIJQD-UHFFFAOYSA-N 0.000 claims description 12
XRXBNTYHQXKSAO-BPCOHUPZSA-N Ganolucidic acid A Natural products O=C(O)[C@@H](CC(=O)C[C@@H](C)[C@H]1[C@]2(C)[C@](C)([C@@H](O)C1)C1=C(C(=O)C2)[C@]2(C)[C@@H](C(C)(C)C(=O)CC2)CC1)C XRXBNTYHQXKSAO-BPCOHUPZSA-N 0.000 claims description 12
XRXBNTYHQXKSAO-WRRQQOFWSA-N Ganolucidic acid A Chemical compound C([C@@]12C)CC(=O)C(C)(C)[C@@H]1CCC1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)C[C@@H](C)C(O)=O)C)C[C@H](O)[C@]21C XRXBNTYHQXKSAO-WRRQQOFWSA-N 0.000 claims description 12
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 12
HZSSXIBJQNNCMO-UHFFFAOYSA-N methyl ganolucidate A Natural products CC12CCC(=O)C(C)(C)C1CCC1=C2C(=O)CC2(C)C(C(C)CC(=O)CC(C)C(=O)OC)CC(O)C21C HZSSXIBJQNNCMO-UHFFFAOYSA-N 0.000 claims description 12
229930182735 Ganoderic acid Natural products 0.000 claims description 11
239000001569 carbon dioxide Substances 0.000 claims description 11
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 11
235000013305 food Nutrition 0.000 claims description 10
229930193921 lucidenic acid Natural products 0.000 claims description 10
BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 9
239000007788 liquid Substances 0.000 claims description 9
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 8
LIJZGBVDQCTWLG-RVFLQCAWSA-N Ganodermatriol Chemical compound CC1(C)[C@@H](O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CCC=C(CO)CO)C)CC[C@@]4(C)C3=CC[C@H]21 LIJZGBVDQCTWLG-RVFLQCAWSA-N 0.000 claims description 7
LIJZGBVDQCTWLG-UZQZWLGQSA-N Ganodermatriol Natural products OC/C(=C\CC[C@@H](C)[C@@H]1[C@]2(C)[C@](C)(C=3C([C@]4(C)[C@@H](C(C)(C)[C@@H](O)CC4)CC=3)=CC2)CC1)/CO LIJZGBVDQCTWLG-UZQZWLGQSA-N 0.000 claims description 7
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 7
229930192673 ganolucidic acid Natural products 0.000 claims description 7
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 7
OYHQOLUKZRVURQ-AVQMFFATSA-N linoelaidic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-AVQMFFATSA-N 0.000 claims description 7
238000001556 precipitation Methods 0.000 claims description 7
HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 7
ARXHRTZAVQOQEU-UHFFFAOYSA-N (10R)-3c,5t,6t-Trihydroxy-10r,13c-dimethyl-17c-((1R:4R)-1,4,5-trimethyl-hexen-(2t)-yl)-(9tH,14tH)-Delta7-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(C)C(C)C)CCC33)C)C3=CC(O)C21O ARXHRTZAVQOQEU-UHFFFAOYSA-N 0.000 claims description 6
WVXIJNYYNKDLPE-YFDYNRBPSA-N Lucidone Natural products COC1=CC(=O)C(=C(O)/C=C/c2ccccc2)C1=O WVXIJNYYNKDLPE-YFDYNRBPSA-N 0.000 claims description 6
ANPTXNYQLGJVRE-BQYQJAHWSA-N Lucidone Chemical compound COC1=CC(=O)C(C(=O)\C=C\C=2C=CC=CC=2)=C1O ANPTXNYQLGJVRE-BQYQJAHWSA-N 0.000 claims description 6
230000001476 alcoholic effect Effects 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 6
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 6
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 6
ARXHRTZAVQOQEU-BRVLHLJYSA-N cerevisterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@H]33)C)C3=C[C@@H](O)[C@]21O ARXHRTZAVQOQEU-BRVLHLJYSA-N 0.000 claims description 6
ARXHRTZAVQOQEU-SXOCEXOESA-N cerevisterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@@H]2C3=C[C@H](O)[C@@]4(O)C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C ARXHRTZAVQOQEU-SXOCEXOESA-N 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
239000008103 glucose Substances 0.000 claims description 6
238000000638 solvent extraction Methods 0.000 claims description 6
OYHQOLUKZRVURQ-UHFFFAOYSA-N 9,12-Octadecadienoic Acid Chemical compound CCCCCC=CCC=CCCCCCCCC(O)=O OYHQOLUKZRVURQ-UHFFFAOYSA-N 0.000 claims description 5
229930182942 Ganoderal Natural products 0.000 claims description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 5
229930184104 ganoderiol Natural products 0.000 claims description 5
238000000926 separation method Methods 0.000 claims description 5
KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 claims description 5
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 4
229930184754 Lucidumol Natural products 0.000 claims description 4
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 4
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
230000001376 precipitating effect Effects 0.000 claims description 4
KASALCUNLBTNAA-LIPCCPSCSA-N Ganodermanontriol Chemical compound CC1(C)C(=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CC[C@H](O)[C@](C)(O)CO)C)CC[C@@]4(C)C3=CC[C@H]21 KASALCUNLBTNAA-LIPCCPSCSA-N 0.000 claims description 3
JPLNPSCODMUBRP-UHFFFAOYSA-N Ganodermanontriol Natural products CC(CCCC(O)(CO)CO)C1CCC2(C)C3=CCC4C(C)(C)C(=O)CCC4(C)C3=CCC12C JPLNPSCODMUBRP-UHFFFAOYSA-N 0.000 claims description 3
235000021355 Stearic acid Nutrition 0.000 claims description 3
229960000541 cetyl alcohol Drugs 0.000 claims description 3
YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 claims description 3
CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 claims description 3
238000004949 mass spectrometry Methods 0.000 claims description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 3
XOALFFJGWSCQEO-UHFFFAOYSA-N tridecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCOC(=O)C=C XOALFFJGWSCQEO-UHFFFAOYSA-N 0.000 claims description 3
BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 claims description 2
CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 claims description 2
XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 claims description 2
FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 claims description 2
JVGJXXNUVVQEIG-MCKXIFHVSA-N Ganoderiol F Chemical compound CC1(C)C(=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CCC=C(CO)CO)C)CC[C@@]4(C)C3=CC[C@H]21 JVGJXXNUVVQEIG-MCKXIFHVSA-N 0.000 claims description 2
AOXXVRDKZLRGTJ-ZNWNZREOSA-N Ganodermadiol Natural products OC/C(=C\CC[C@@H](C)[C@@H]1[C@]2(C)[C@](C)(C=3C([C@]4(C)[C@@H](C(C)(C)[C@@H](O)CC4)CC=3)=CC2)CC1)/C AOXXVRDKZLRGTJ-ZNWNZREOSA-N 0.000 claims description 2
AAJIHHYEPHRIET-XEFAKFPISA-N Ganodermanondiol Chemical compound CC1(C)C(=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CC[C@H](O)C(C)(C)O)C)CC[C@@]4(C)C3=CC[C@H]21 AAJIHHYEPHRIET-XEFAKFPISA-N 0.000 claims description 2
YTQAKTDSTUEPNZ-JREPXQSNSA-N Ganodermanondiol Natural products C[C@H](CC[C@H](C)C(C)(C)O)[C@H]1CC[C@@]2(C)C3=CC[C@H]4C(C)(C)C(=O)CC[C@]4(C)C3=CC[C@]12C YTQAKTDSTUEPNZ-JREPXQSNSA-N 0.000 claims description 2
AVYUIGCRCPQERA-RVFLQCAWSA-N Ganoderol B Natural products C[C@H](CC=CC(CO)CO)[C@H]1CC[C@@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)C3=CC[C@]12C AVYUIGCRCPQERA-RVFLQCAWSA-N 0.000 claims description 2
BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 claims description 2
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 2
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 2
LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 claims description 2
GYRDSOABOBCYST-HFAARYGVSA-N Lucidenic acid B Chemical compound O=C(O)CC[C@@H](C)[C@@H]1[C@@]2(C)[C@H](O)C(=O)C=3[C@]4(C)[C@H](C(C)(C)C(=O)CC4)C[C@H](O)C=3[C@]2(C)C(=O)C1 GYRDSOABOBCYST-HFAARYGVSA-N 0.000 claims description 2
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WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 2
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 claims description 2
ZQPPMHVWECSIRJ-MDZDMXLPSA-N elaidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCC(O)=O ZQPPMHVWECSIRJ-MDZDMXLPSA-N 0.000 claims description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Mycology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Botany (AREA)
Alternative & Traditional Medicine (AREA)
Microbiology (AREA)
Medical Informatics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Obesity (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

CA002643785A 2006-03-23 2007-03-23 Extracts and methods comprising ganoderma species Abandoned CA2643785A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US78512506P	2006-03-23	2006-03-23
US60/785,125		2006-03-23
PCT/US2007/064829 WO2007109801A2 (en)	2006-03-23	2007-03-23	Extracts and methods comprising ganoderma species

Publications (1)

Publication Number	Publication Date
CA2643785A1 true CA2643785A1 (en)	2007-09-27

Family

ID=38523336

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002643785A Abandoned CA2643785A1 (en)	2006-03-23	2007-03-23	Extracts and methods comprising ganoderma species

Country Status (11)

Country	Link
US (1)	US20080112966A1 (de)
EP (1)	EP2012808A4 (de)
JP (1)	JP2009531330A (de)
KR (1)	KR20090018886A (de)
CN (1)	CN101410129A (de)
AU (1)	AU2007227383A1 (de)
BR (1)	BRPI0708825A2 (de)
CA (1)	CA2643785A1 (de)
IL (1)	IL193832A0 (de)
MX (1)	MX2008012066A (de)
WO (1)	WO2007109801A2 (de)

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CN103550264B (zh) *	2013-11-01	2015-07-22	王颖	一种灵芝精华物质的提取方法
CN103724389B (zh) *	2013-12-23	2015-09-02	福建仙芝楼生物科技有限公司	一种分离制备抗肿瘤成分灵芝酸c1和灵芝酸f的方法
JP2016044155A (ja) *	2014-08-25	2016-04-04	国立大学法人九州大学	ノイラミニダーゼ阻害剤、これを含有した抗インフルエンザ剤、食品および薬剤、並びにそれらの製造方法
CN105878298A (zh) *	2014-12-18	2016-08-24	陈亚海	使用超临界流体工艺萃取灵芝精油的方法
CN108138078A (zh) *	2015-09-30	2018-06-08	公立大学法人大阪府立大学	植物油的制造方法以及制造装置
CN105968257B (zh) *	2016-04-15	2018-09-25	南京中医药大学	一种灵芝酸a分子印迹聚合物的制备方法及其应用
CN108892651B (zh) *	2018-08-01	2022-06-07	中国科学院昆明植物研究所	一种混源萜二聚体类化合物及其药物组合物和其应用
US11221179B2 (en)	2018-10-26	2022-01-11	E. & J. Gallo Winery	Low profile design air tunnel system and method for providing uniform air flow in a refractance window dryer
WO2021158990A1 (en) *	2020-02-07	2021-08-12	Arizona Board Of Regents On Behalf Of The University Of Arizona	Therapeutic fractions and proteins from asthma-protective farm dust
US20230026406A1 (en) *	2018-12-14	2023-01-26	Arizona Board Of Regents On Behalf Of The University Of Arizona	Therapeutic fractions and proteins from asthma-protective farm dust
JP2019163292A (ja) *	2019-05-13	2019-09-26	国立大学法人九州大学	ノイラミニダーゼ阻害剤、これを含有した抗インフルエンザ剤、食品および薬剤、並びにそれらの製造方法
CN110143992A (zh) *	2019-05-28	2019-08-20	中国科学院昆明植物研究所	具有抗炎活性的麦角甾醇类化合物及其制备方法和应用
KR20210123853A (ko)	2020-04-06	2021-10-14	한국과학기술연구원	가노데릭산을 포함하는 아토피, 건선 또는 피부염증의 치료, 예방 또는 경감용 조성물 및 이의 제조 방법
CN111705093A (zh) *	2020-06-29	2020-09-25	天津科技大学	绿色木霉菌发酵灵芝子实体制备多糖的方法
CN111662393A (zh) *	2020-07-01	2020-09-15	广东悦生生物科技有限公司	一种灵芝的全组分提取方法
CN111829979B (zh) *	2020-07-20	2023-09-12	中国科学院合肥物质科学研究院	一种基于nir光谱定量测定灵芝子实体中总三萜的方法
CN112326853B (zh) *	2020-11-06	2022-10-11	上海市农业科学院	一种同时检测灵芝子实体中25个三萜化合物的方法
CN113109556A (zh) *	2021-04-19	2021-07-13	河北农业大学	一种灵芝酸a的检测方法
CN113917033B (zh) *	2021-10-18	2023-07-04	上海市农业科学院	一种检测灵芝属真菌中性三萜的方法
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CN115040895B (zh) *	2022-06-10	2024-02-09	南京中科药业有限公司	一种去除灵芝孢子粉中游离脂肪酸的方法
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2007
- 2007-03-23 AU AU2007227383A patent/AU2007227383A1/en not_active Abandoned
- 2007-03-23 WO PCT/US2007/064829 patent/WO2007109801A2/en not_active Ceased
- 2007-03-23 US US11/690,622 patent/US20080112966A1/en not_active Abandoned
- 2007-03-23 BR BRPI0708825-6A patent/BRPI0708825A2/pt not_active Application Discontinuation
- 2007-03-23 JP JP2009501755A patent/JP2009531330A/ja not_active Withdrawn
- 2007-03-23 MX MX2008012066A patent/MX2008012066A/es not_active Application Discontinuation
- 2007-03-23 CN CNA2007800104704A patent/CN101410129A/zh active Pending
- 2007-03-23 KR KR1020087026006A patent/KR20090018886A/ko not_active Withdrawn
- 2007-03-23 EP EP07759286A patent/EP2012808A4/de not_active Withdrawn
- 2007-03-23 CA CA002643785A patent/CA2643785A1/en not_active Abandoned
2008
- 2008-09-02 IL IL193832A patent/IL193832A0/en unknown

Also Published As

Publication number	Publication date
WO2007109801A2 (en)	2007-09-27
MX2008012066A (es)	2008-10-07
CN101410129A (zh)	2009-04-15
KR20090018886A (ko)	2009-02-24
EP2012808A4 (de)	2009-12-09
AU2007227383A1 (en)	2007-09-27
US20080112966A1 (en)	2008-05-15
JP2009531330A (ja)	2009-09-03
EP2012808A2 (de)	2009-01-14
WO2007109801A3 (en)	2007-11-08
IL193832A0 (en)	2009-08-03
BRPI0708825A2 (pt)	2011-06-14

Legal Events

Date	Code	Title	Description
2011-03-23	FZDE	Discontinued

Publication	Publication Date	Title
CA2643785A1 (en)	2007-09-27	Extracts and methods comprising ganoderma species
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US20070248700A1 (en)	2007-10-25	Extractions and Methods Comprising Elder Species
WO2008070783A2 (en)	2008-06-12	Compositions and methods comprising zingiber species
JP2009508877A (ja)	2009-03-05	パナックス種を含む組成物及び方法
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HK1130690A (en)	2010-01-08	Extracts and methods comprising ganoderma species
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