CA2652500C - Produit pharmaceutique enrobe destine a une administration intrabuccale de nicotine comprenant du trometamol servant d'agent tampon - Google Patents

Produit pharmaceutique enrobe destine a une administration intrabuccale de nicotine comprenant du trometamol servant d'agent tampon Download PDF

Info

Publication number: CA2652500C
Authority: CA; Canada
Prior art keywords: nicotine; coating; product according; core; coated
Prior art date: 2006-05-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2652500A

Other languages

English (en)

Other versions

CA2652500A1 (fr

Inventor

Per Steen

Darek Dymitrowicz

Asa Waltermo

Roland Olsson

Katarina Lindell

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

McNeil AB

Original Assignee

McNeil AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-16

Filing date

2007-04-18

Publication date

2014-07-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38694149&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2652500(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-18 Application filed by McNeil AB filed Critical McNeil AB

2007-11-22 Publication of CA2652500A1 publication Critical patent/CA2652500A1/fr

2014-07-29 Application granted granted Critical

2014-07-29 Publication of CA2652500C publication Critical patent/CA2652500C/fr

Status Expired - Fee Related legal-status Critical Current

2027-04-18 Anticipated expiration legal-status Critical

Links

SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 354
229960002715 nicotine Drugs 0.000 title claims abstract description 348
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 347
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 title claims abstract description 50
229960000281 trometamol Drugs 0.000 title claims abstract description 50
239000006172 buffering agent Substances 0.000 title claims abstract description 32
238000012384 transportation and delivery Methods 0.000 title claims abstract description 21
239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
229940127557 pharmaceutical product Drugs 0.000 title claims description 7
239000011247 coating layer Substances 0.000 claims abstract description 67
238000000034 method Methods 0.000 claims abstract description 65
235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 60
241000208125 Nicotiana Species 0.000 claims abstract description 58
230000009467 reduction Effects 0.000 claims abstract description 32
239000000779 smoke Substances 0.000 claims abstract description 30
239000000654 additive Substances 0.000 claims abstract description 28
239000003795 chemical substances by application Substances 0.000 claims abstract description 27
238000004519 manufacturing process Methods 0.000 claims abstract description 22
235000015218 chewing gum Nutrition 0.000 claims description 86
239000003826 tablet Substances 0.000 claims description 84
238000000576 coating method Methods 0.000 claims description 82
239000011248 coating agent Substances 0.000 claims description 79
229940112822 chewing gum Drugs 0.000 claims description 77
230000000391 smoking effect Effects 0.000 claims description 65
239000000203 mixture Substances 0.000 claims description 54
210000000214 mouth Anatomy 0.000 claims description 47
239000000872 buffer Substances 0.000 claims description 34
239000012458 free base Substances 0.000 claims description 30
210000003296 saliva Anatomy 0.000 claims description 30
239000002585 base Substances 0.000 claims description 27
-1 nicotine cation Chemical class 0.000 claims description 21
238000009472 formulation Methods 0.000 claims description 18
239000004615 ingredient Substances 0.000 claims description 17
208000025569 Tobacco Use disease Diseases 0.000 claims description 15
230000002459 sustained effect Effects 0.000 claims description 14
RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 claims description 13
239000010410 layer Substances 0.000 claims description 13
238000002156 mixing Methods 0.000 claims description 13
239000000796 flavoring agent Substances 0.000 claims description 12
239000000463 material Substances 0.000 claims description 12
239000007937 lozenge Substances 0.000 claims description 11
238000005096 rolling process Methods 0.000 claims description 11
239000000126 substance Substances 0.000 claims description 11
238000011282 treatment Methods 0.000 claims description 11
238000010521 absorption reaction Methods 0.000 claims description 10
229910052783 alkali metal Inorganic materials 0.000 claims description 10
230000003139 buffering effect Effects 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
235000003599 food sweetener Nutrition 0.000 claims description 10
239000003765 sweetening agent Substances 0.000 claims description 10
230000000996 additive effect Effects 0.000 claims description 9
230000004888 barrier function Effects 0.000 claims description 9
235000019634 flavors Nutrition 0.000 claims description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 8
229920000858 Cyclodextrin Polymers 0.000 claims description 8
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
229910019142 PO4 Inorganic materials 0.000 claims description 8
201000010099 disease Diseases 0.000 claims description 8
238000009501 film coating Methods 0.000 claims description 8
239000007888 film coating Substances 0.000 claims description 8
239000010452 phosphate Substances 0.000 claims description 8
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
239000007787 solid Substances 0.000 claims description 8
235000019640 taste Nutrition 0.000 claims description 8
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 7
229920002472 Starch Polymers 0.000 claims description 7
150000001340 alkali metals Chemical class 0.000 claims description 7
229910052708 sodium Inorganic materials 0.000 claims description 7
239000008107 starch Substances 0.000 claims description 7
235000019698 starch Nutrition 0.000 claims description 7
208000024827 Alzheimer disease Diseases 0.000 claims description 6
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 6
208000011231 Crohn disease Diseases 0.000 claims description 6
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
206010057852 Nicotine dependence Diseases 0.000 claims description 6
208000018737 Parkinson disease Diseases 0.000 claims description 6
208000000323 Tourette Syndrome Diseases 0.000 claims description 6
208000016620 Tourette disease Diseases 0.000 claims description 6
239000003963 antioxidant agent Substances 0.000 claims description 6
YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 6
239000007910 chewable tablet Substances 0.000 claims description 6
229940068682 chewable tablet Drugs 0.000 claims description 6
206010009887 colitis Diseases 0.000 claims description 6
235000009508 confectionery Nutrition 0.000 claims description 6
239000000155 melt Substances 0.000 claims description 6
150000003839 salts Chemical group 0.000 claims description 6
239000011734 sodium Substances 0.000 claims description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims description 5
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 5
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 5
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 5
239000004005 microsphere Substances 0.000 claims description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 5
229910052700 potassium Inorganic materials 0.000 claims description 5
239000011591 potassium Substances 0.000 claims description 5
229940071207 sesquicarbonate Drugs 0.000 claims description 5
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 5
239000007921 spray Substances 0.000 claims description 5
230000001839 systemic circulation Effects 0.000 claims description 5
238000002560 therapeutic procedure Methods 0.000 claims description 5
238000004260 weight control Methods 0.000 claims description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 4
239000001856 Ethyl cellulose Substances 0.000 claims description 4
FEWJPZIEWOKRBE-JCYAYHJZSA-M L-tartrate(1-) Chemical compound OC(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-M 0.000 claims description 4
150000001768 cations Chemical class 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 4
239000001913 cellulose Substances 0.000 claims description 4
235000019325 ethyl cellulose Nutrition 0.000 claims description 4
229920001249 ethyl cellulose Polymers 0.000 claims description 4
229920000159 gelatin Polymers 0.000 claims description 4
235000019322 gelatine Nutrition 0.000 claims description 4
229940050410 gluconate Drugs 0.000 claims description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
150000002632 lipids Chemical class 0.000 claims description 4
239000004014 plasticizer Substances 0.000 claims description 4
239000003755 preservative agent Substances 0.000 claims description 4
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 4
239000003381 stabilizer Substances 0.000 claims description 4
239000001993 wax Substances 0.000 claims description 4
239000010457 zeolite Substances 0.000 claims description 4
OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 claims description 4
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 3
229960002504 capsaicin Drugs 0.000 claims description 3
235000017663 capsaicin Nutrition 0.000 claims description 3
239000003995 emulsifying agent Substances 0.000 claims description 3
239000003623 enhancer Substances 0.000 claims description 3
239000000945 filler Substances 0.000 claims description 3
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
239000007922 nasal spray Substances 0.000 claims description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
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239000004150 EU approved colour Substances 0.000 claims description 2
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
239000008376 breath freshener Substances 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
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229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 claims description 2
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229920000058 polyacrylate Polymers 0.000 claims description 2
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239000002562 thickening agent Substances 0.000 claims description 2
239000007852 tooth bleaching agent Substances 0.000 claims description 2
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HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA2652500A 2006-05-16 2007-04-18 Produit pharmaceutique enrobe destine a une administration intrabuccale de nicotine comprenant du trometamol servant d'agent tampon Expired - Fee Related CA2652500C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0601090		2006-05-16
SE0601090-4		2006-05-16
PCT/SE2007/000365 WO2007133141A1 (fr)	2006-05-16	2007-04-18	Produit pharmaceutique enrobé destiné à une administration intrabuccale de nicotine comprenant du trométamol servant d'agent tampon

Publications (2)

Publication Number	Publication Date
CA2652500A1 CA2652500A1 (fr)	2007-11-22
CA2652500C true CA2652500C (fr)	2014-07-29

Family

ID=38694149

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2652500A Expired - Fee Related CA2652500C (fr)	2006-05-16	2007-04-18	Produit pharmaceutique enrobe destine a une administration intrabuccale de nicotine comprenant du trometamol servant d'agent tampon

Country Status (16)

Country	Link
US (1)	US20070269492A1 (fr)
EP (1)	EP2023928A4 (fr)
JP (1)	JP5254213B2 (fr)
KR (1)	KR101414063B1 (fr)
CN (1)	CN101472591A (fr)
AR (1)	AR060931A1 (fr)
AU (1)	AU2007250589B2 (fr)
BR (1)	BRPI0712068A2 (fr)
CA (1)	CA2652500C (fr)
MX (1)	MX2008014726A (fr)
NO (1)	NO20084987L (fr)
NZ (1)	NZ572758A (fr)
RU (1)	RU2448707C2 (fr)
TW (1)	TW200810755A (fr)
WO (1)	WO2007133141A1 (fr)
ZA (1)	ZA200810618B (fr)

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US8642016B2 (en)	2006-07-21	2014-02-04	Jsrnti, Llc	Medicinal delivery system, and related methods
EP1977746B8 (fr) *	2007-04-02	2014-09-24	Parkinson's Institute	Procédés et compositions pour la réduction des effets indésirables de traitements thérapeutiques
GB2468424B (en) *	2007-04-02	2011-11-09	Parkinson S Inst	Methods and compositions for reduction of side effects of therapeutic treatments
US20080286341A1 (en) *	2007-05-16	2008-11-20	Sven-Borje Andersson	Buffered coated nicotine containing products
CL2009001025A1 (es) *	2008-05-01	2010-09-24	Smithkline Beecham Corp	Composicion de pastilla para chupar que comprende: a) un granulo patron con al menos: un agente tampon alcalino, un modificador de la disolucion y una carga, b) un principio activo de nicotina definido extragranular y al menos un agente tampon alcalino; procedimiento de preparacion; util para eliminar o reducir el uso de tabaco.
AU2013219211B2 (en) *	2008-05-01	2016-05-12	North Star OpCo Limited	Nicotine lozenge compositions
EP2177213B1 (fr) *	2008-09-17	2013-01-02	Siegfried Ltd.	Granulé contenant de la nicotine
PT2361081T (pt)	2008-10-14	2016-09-05	Mcneil Ab	Forma de dosagem intra-oral multiporção e seu uso
PT2198865E (pt) *	2008-12-19	2012-02-07	Siegfried Ltd	Produto que contém nicotina
US20100247586A1 (en) *	2009-03-27	2010-09-30	Andreas Hugerth	Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
EP2442668B1 (fr) *	2009-06-19	2016-08-10	Fertin Pharma A/S	Base de gomme tamponnee pour liberation elevee de ph
EP2536409A4 (fr) *	2010-02-18	2013-07-17	Jatin Vasant Thakkar	Pastilles de gélatine molles contenant de la nicotine
US20110268809A1 (en)	2010-04-28	2011-11-03	Paul Andrew Brinkley	Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en)	2010-05-07	2011-11-10	Borschke August J	Nicotine-containing pharmaceutical compositions
US20130017259A1 (en)	2011-07-06	2013-01-17	The Parkinson's Institute	Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
US20130078307A1 (en)	2011-09-22	2013-03-28	Niconovum Usa, Inc.	Nicotine-containing pharmaceutical composition
US9629392B2 (en)	2011-09-22	2017-04-25	R.J. Reynolds Tobacco Company	Translucent smokeless tobacco product
US9474303B2 (en)	2011-09-22	2016-10-25	R.J. Reynolds Tobacco Company	Translucent smokeless tobacco product
US9084439B2 (en)	2011-09-22	2015-07-21	R.J. Reynolds Tobacco Company	Translucent smokeless tobacco product
US9907748B2 (en)	2011-10-21	2018-03-06	Niconovum Usa, Inc.	Excipients for nicotine-containing therapeutic compositions
US20130177646A1 (en) *	2012-01-05	2013-07-11	Mcneil Ab	Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance
US9763928B2 (en)	2012-02-10	2017-09-19	Niconovum Usa, Inc.	Multi-layer nicotine-containing pharmaceutical composition
US9044035B2 (en)	2012-04-17	2015-06-02	R.J. Reynolds Tobacco Company	Remelted ingestible products
FR2993778B1 (fr) *	2012-07-30	2016-06-17	Pf Medicament	Pastilles a cinetiques multiples de liberation de principes actifs
CN102926277B (zh) *	2012-11-14	2015-05-20	湖南中烟工业有限责任公司	一种β-环糊精-g-乳酸共聚物的应用
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2006
- 2006-06-01 US US11/444,775 patent/US20070269492A1/en not_active Abandoned
2007
- 2007-04-18 CA CA2652500A patent/CA2652500C/fr not_active Expired - Fee Related
- 2007-04-18 BR BRPI0712068-0A patent/BRPI0712068A2/pt not_active Application Discontinuation
- 2007-04-18 EP EP07748030A patent/EP2023928A4/fr not_active Withdrawn
- 2007-04-18 MX MX2008014726A patent/MX2008014726A/es active IP Right Grant
- 2007-04-18 WO PCT/SE2007/000365 patent/WO2007133141A1/fr not_active Ceased
- 2007-04-18 JP JP2009510917A patent/JP5254213B2/ja not_active Expired - Fee Related
- 2007-04-18 AU AU2007250589A patent/AU2007250589B2/en not_active Ceased
- 2007-04-18 KR KR1020087030673A patent/KR101414063B1/ko not_active Expired - Fee Related
- 2007-04-18 NZ NZ572758A patent/NZ572758A/en not_active IP Right Cessation
- 2007-04-18 CN CNA2007800232492A patent/CN101472591A/zh active Pending
- 2007-04-18 RU RU2008149508/15A patent/RU2448707C2/ru not_active IP Right Cessation
- 2007-05-15 TW TW096117125A patent/TW200810755A/zh unknown
- 2007-05-15 AR ARP070102085A patent/AR060931A1/es not_active Application Discontinuation
2008
- 2008-11-27 NO NO20084987A patent/NO20084987L/no not_active Application Discontinuation
- 2008-12-15 ZA ZA2008/10618A patent/ZA200810618B/en unknown

Also Published As

Publication number	Publication date
RU2448707C2 (ru)	2012-04-27
WO2007133141A1 (fr)	2007-11-22
EP2023928A4 (fr)	2012-08-29
US20070269492A1 (en)	2007-11-22
AU2007250589A1 (en)	2007-11-22
NZ572758A (en)	2011-01-28
MX2008014726A (es)	2009-02-04
JP2009537514A (ja)	2009-10-29
RU2008149508A (ru)	2010-06-27
AR060931A1 (es)	2008-07-23
EP2023928A1 (fr)	2009-02-18
BRPI0712068A2 (pt)	2012-01-17
NO20084987L (no)	2009-02-16
CN101472591A (zh)	2009-07-01
KR101414063B1 (ko)	2014-07-18
KR20090024161A (ko)	2009-03-06
ZA200810618B (en)	2010-02-24
TW200810755A (en)	2008-03-01
CA2652500A1 (fr)	2007-11-22
JP5254213B2 (ja)	2013-08-07
AU2007250589B2 (en)	2011-04-14

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Date	Code	Title	Description
2011-12-14	EEER	Examination request
2020-10-13	MKLA	Lapsed	Effective date: 20200831

Publication	Publication Date	Title
AU2007250589B2 (en)	2011-04-14	Coated pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent
AU2002345454B2 (en)	2006-07-20	A coated nicotine-containing chewing gum, manufacture and use thereof
CA2652499C (fr)	2013-12-17	Produit pharmaceutique destine a une administration intrabuccale de nicotine comprenant du trometamol servant d'agent tampon
US20080286341A1 (en)	2008-11-20	Buffered coated nicotine containing products
EP2152313B1 (fr)	2014-09-03	Formulation nicotinique orale tamponnée aux acides aminés
AU2002345454A1 (en)	2003-05-15	A coated nicotine-containing chewing gum, manufacture and use thereof
HK1131889A (en)	2010-04-30	Coated pharmaceutical product for intraoral delivery of nicotine comprising trometamol as buffering agent
HK1144907A (en)	2011-03-18	Oral nicotine formulation buffered with amino acid