CA2652667A1 - Therapeutic combination for painful medical conditions - Google Patents

Therapeutic combination for painful medical conditions Download PDF

Info

Publication number: CA2652667A1
Authority: CA; Canada
Prior art keywords: pain; combination; agent; lacosamide; lower alkyl
Prior art date: 2006-06-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002652667A

Other languages

English (en)

French (fr)

Inventor

Bettina Beyreuther

Thomas Stoehr

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UCB Pharma GmbH

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-08

Filing date

2007-06-06

Publication date

2007-12-13

2006-08-18 Priority claimed from US11/506,577 external-priority patent/US20070042969A1/en

2006-08-18 Priority claimed from US11/506,524 external-priority patent/US20070043120A1/en

2006-08-18 Priority claimed from US11/506,578 external-priority patent/US20070048372A1/en

2006-08-18 Priority claimed from US11/506,523 external-priority patent/US20070197657A1/en

2007-06-06 Application filed by Individual filed Critical Individual

2007-12-13 Publication of CA2652667A1 publication Critical patent/CA2652667A1/en

Status Abandoned legal-status Critical Current

Links

230000001225 therapeutic effect Effects 0.000 title claims abstract description 31
229960002623 lacosamide Drugs 0.000 claims abstract description 201
VPPJLAIAVCUEMN-GFCCVEGCSA-N lacosamide Chemical compound COC[C@@H](NC(C)=O)C(=O)NCC1=CC=CC=C1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 0.000 claims abstract description 196
208000002193 Pain Diseases 0.000 claims abstract description 179
239000003795 chemical substances by application Substances 0.000 claims abstract description 171
230000036407 pain Effects 0.000 claims abstract description 156
150000001875 compounds Chemical class 0.000 claims abstract description 107
230000002917 arthritic effect Effects 0.000 claims abstract description 54
238000011282 treatment Methods 0.000 claims abstract description 54
150000003839 salts Chemical class 0.000 claims abstract description 48
239000002552 dosage form Substances 0.000 claims abstract description 28
125000000217 alkyl group Chemical group 0.000 claims description 122
-1 methylpyrrolyl Chemical group 0.000 claims description 117
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 102
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 78
125000003118 aryl group Chemical group 0.000 claims description 66
230000000694 effects Effects 0.000 claims description 65
239000001257 hydrogen Substances 0.000 claims description 57
229910052739 hydrogen Inorganic materials 0.000 claims description 57
230000002757 inflammatory effect Effects 0.000 claims description 51
229960005181 morphine Drugs 0.000 claims description 49
208000004454 Hyperalgesia Diseases 0.000 claims description 46
208000004296 neuralgia Diseases 0.000 claims description 45
238000000034 method Methods 0.000 claims description 44
125000000623 heterocyclic group Chemical group 0.000 claims description 43
206010065390 Inflammatory pain Diseases 0.000 claims description 39
239000003814 drug Substances 0.000 claims description 39
208000021722 neuropathic pain Diseases 0.000 claims description 39
229940079593 drug Drugs 0.000 claims description 37
229960002870 gabapentin Drugs 0.000 claims description 37
206010012601 diabetes mellitus Diseases 0.000 claims description 35
229960004640 memantine Drugs 0.000 claims description 35
125000006575 electron-withdrawing group Chemical group 0.000 claims description 31
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CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 29
230000003349 osteoarthritic effect Effects 0.000 claims description 29
125000003342 alkenyl group Chemical group 0.000 claims description 28
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 28
CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 27
125000000304 alkynyl group Chemical group 0.000 claims description 27
229960002009 naproxen Drugs 0.000 claims description 27
206010003246 arthritis Diseases 0.000 claims description 25
125000000753 cycloalkyl group Chemical group 0.000 claims description 23
208000035154 Hyperesthesia Diseases 0.000 claims description 22
ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 21
125000003545 alkoxy group Chemical group 0.000 claims description 21
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125000001424 substituent group Chemical group 0.000 claims description 21
206010039073 rheumatoid arthritis Diseases 0.000 claims description 19
208000024891 symptom Diseases 0.000 claims description 19
229960001233 pregabalin Drugs 0.000 claims description 17
AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 17
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
208000000094 Chronic Pain Diseases 0.000 claims description 14
230000008859 change Effects 0.000 claims description 14
208000032131 Diabetic Neuropathies Diseases 0.000 claims description 13
210000000988 bone and bone Anatomy 0.000 claims description 13
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206010019233 Headaches Diseases 0.000 claims description 12
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239000000730 antalgic agent Substances 0.000 claims description 12
125000004414 alkyl thio group Chemical group 0.000 claims description 11
239000001961 anticonvulsive agent Substances 0.000 claims description 11
229960004193 dextropropoxyphene Drugs 0.000 claims description 11
XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 11
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 11
208000000112 Myalgia Diseases 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
125000004076 pyridyl group Chemical group 0.000 claims description 10
239000000935 antidepressant agent Substances 0.000 claims description 9
229940005513 antidepressants Drugs 0.000 claims description 9
125000002541 furyl group Chemical group 0.000 claims description 9
125000000714 pyrimidinyl group Chemical group 0.000 claims description 9
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 8
208000008035 Back Pain Diseases 0.000 claims description 8
208000001640 Fibromyalgia Diseases 0.000 claims description 8
208000030858 Myofascial Pain Syndromes Diseases 0.000 claims description 8
DEXMFYZAHXMZNM-UHFFFAOYSA-N Narceine Chemical compound OC(=O)C1=C(OC)C(OC)=CC=C1C(=O)CC1=C(CCN(C)C)C=C(OCO2)C2=C1OC DEXMFYZAHXMZNM-UHFFFAOYSA-N 0.000 claims description 8
206010036105 Polyneuropathy Diseases 0.000 claims description 8
125000003282 alkyl amino group Chemical group 0.000 claims description 8
206010053552 allodynia Diseases 0.000 claims description 8
229940035676 analgesics Drugs 0.000 claims description 8
229940125681 anticonvulsant agent Drugs 0.000 claims description 8
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 8
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 8
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 8
230000007824 polyneuropathy Effects 0.000 claims description 8
125000003373 pyrazinyl group Chemical group 0.000 claims description 8
230000001953 sensory effect Effects 0.000 claims description 8
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 7
208000003456 Juvenile Arthritis Diseases 0.000 claims description 7
206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 7
ALFGKMXHOUSVAD-UHFFFAOYSA-N Ketobemidone Chemical compound C=1C=CC(O)=CC=1C1(C(=O)CC)CCN(C)CC1 ALFGKMXHOUSVAD-UHFFFAOYSA-N 0.000 claims description 7
230000001154 acute effect Effects 0.000 claims description 7
208000005298 acute pain Diseases 0.000 claims description 7
210000004556 brain Anatomy 0.000 claims description 7
230000008355 cartilage degradation Effects 0.000 claims description 7
208000019069 chronic childhood arthritis Diseases 0.000 claims description 7
238000007906 compression Methods 0.000 claims description 7
230000006835 compression Effects 0.000 claims description 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
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229960003029 ketobemidone Drugs 0.000 claims description 7
229960001797 methadone Drugs 0.000 claims description 7
230000002981 neuropathic effect Effects 0.000 claims description 7
230000002093 peripheral effect Effects 0.000 claims description 7
230000002085 persistent effect Effects 0.000 claims description 7
230000002265 prevention Effects 0.000 claims description 7
210000000278 spinal cord Anatomy 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
YSGASDXSLKIKOD-UHFFFAOYSA-N 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide Chemical compound C=1C=CC=CC=1C(C)(NC(=O)CN)CC1=CC=CC=C1 YSGASDXSLKIKOD-UHFFFAOYSA-N 0.000 claims description 6
206010065952 Hyperpathia Diseases 0.000 claims description 6
208000019695 Migraine disease Diseases 0.000 claims description 6
206010028980 Neoplasm Diseases 0.000 claims description 6
206010029174 Nerve compression Diseases 0.000 claims description 6
208000028389 Nerve injury Diseases 0.000 claims description 6
208000005890 Neuroma Diseases 0.000 claims description 6
208000010886 Peripheral nerve injury Diseases 0.000 claims description 6
206010034620 Peripheral sensory neuropathy Diseases 0.000 claims description 6
208000004983 Phantom Limb Diseases 0.000 claims description 6
206010056238 Phantom pain Diseases 0.000 claims description 6
AJOQSQHYDOFIOX-UHFFFAOYSA-N Pheneturide Chemical compound NC(=O)NC(=O)C(CC)C1=CC=CC=C1 AJOQSQHYDOFIOX-UHFFFAOYSA-N 0.000 claims description 6
208000001407 Vascular Headaches Diseases 0.000 claims description 6
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 6
201000011510 cancer Diseases 0.000 claims description 6
238000002512 chemotherapy Methods 0.000 claims description 6
230000001684 chronic effect Effects 0.000 claims description 6
231100000869 headache Toxicity 0.000 claims description 6
125000002883 imidazolyl group Chemical group 0.000 claims description 6
206010027599 migraine Diseases 0.000 claims description 6
230000008764 nerve damage Effects 0.000 claims description 6
125000002971 oxazolyl group Chemical group 0.000 claims description 6
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
OJCPSBCUMRIPFL-UHFFFAOYSA-N prolintane Chemical compound C1CCCN1C(CCC)CC1=CC=CC=C1 OJCPSBCUMRIPFL-UHFFFAOYSA-N 0.000 claims description 6
238000001959 radiotherapy Methods 0.000 claims description 6
229950000659 remacemide Drugs 0.000 claims description 6
FGDZQCVHDSGLHJ-UHFFFAOYSA-M rubidium chloride Chemical compound [Cl-].[Rb+] FGDZQCVHDSGLHJ-UHFFFAOYSA-M 0.000 claims description 6
201000005572 sensory peripheral neuropathy Diseases 0.000 claims description 6
QAXBVGVYDCAVLV-UHFFFAOYSA-N tiletamine Chemical compound C=1C=CSC=1C1(NCC)CCCCC1=O QAXBVGVYDCAVLV-UHFFFAOYSA-N 0.000 claims description 6
230000000472 traumatic effect Effects 0.000 claims description 6
230000008736 traumatic injury Effects 0.000 claims description 6
206010044652 trigeminal neuralgia Diseases 0.000 claims description 6
208000006820 Arthralgia Diseases 0.000 claims description 5
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical group SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 5
150000001204 N-oxides Chemical class 0.000 claims description 5
229940127523 NMDA Receptor Antagonists Drugs 0.000 claims description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
125000004104 aryloxy group Chemical group 0.000 claims description 5
208000035475 disorder Diseases 0.000 claims description 5
125000001188 haloalkyl group Chemical group 0.000 claims description 5
125000002098 pyridazinyl group Chemical group 0.000 claims description 5
125000000168 pyrrolyl group Chemical group 0.000 claims description 5
125000001453 quaternary ammonium group Chemical group 0.000 claims description 5
238000007634 remodeling Methods 0.000 claims description 5
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 5
125000000335 thiazolyl group Chemical group 0.000 claims description 5
YQYVFVRQLZMJKJ-JBBXEZCESA-N (+)-cyclazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CC1CC1 YQYVFVRQLZMJKJ-JBBXEZCESA-N 0.000 claims description 4
UVITTYOJFDLOGI-UHFFFAOYSA-N (1,2,5-trimethyl-4-phenylpiperidin-4-yl) propanoate Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CC(C)N(C)CC1C UVITTYOJFDLOGI-UHFFFAOYSA-N 0.000 claims description 4
XTMOQAKCOFLCRZ-UHFFFAOYSA-N (4-acetamidophenyl) 4-nitrooxybutanoate Chemical compound CC(=O)NC1=CC=C(OC(=O)CCCO[N+]([O-])=O)C=C1 XTMOQAKCOFLCRZ-UHFFFAOYSA-N 0.000 claims description 4
LGFMXOTUSSVQJV-NEYUFSEYSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;(4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;1-[(3,4-dimethoxyphenyl)methyl]-6 Chemical compound Cl.Cl.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 LGFMXOTUSSVQJV-NEYUFSEYSA-N 0.000 claims description 4
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 4
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IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 claims description 4
OGDVEMNWJVYAJL-LEPYJNQMSA-N Ethyl morphine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC OGDVEMNWJVYAJL-LEPYJNQMSA-N 0.000 claims description 4
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GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims description 4
208000004575 Infectious Arthritis Diseases 0.000 claims description 4
OZYUPQUCAUTOBP-QXAKKESOSA-N Levallorphan Chemical compound C([C@H]12)CCC[C@@]11CCN(CC=C)[C@@H]2CC2=CC=C(O)C=C21 OZYUPQUCAUTOBP-QXAKKESOSA-N 0.000 claims description 4
JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims description 4
208000016604 Lyme disease Diseases 0.000 claims description 4
XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims description 4
IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims description 4
UIQMVEYFGZJHCZ-SSTWWWIQSA-N Nalorphine Chemical compound C([C@@H](N(CC1)CC=C)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 UIQMVEYFGZJHCZ-SSTWWWIQSA-N 0.000 claims description 4
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ONBWJWYUHXVEJS-ZTYRTETDSA-N Normorphine Chemical compound C([C@@H](NCC1)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 ONBWJWYUHXVEJS-ZTYRTETDSA-N 0.000 claims description 4
239000008896 Opium Substances 0.000 claims description 4
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 4
UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims description 4
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 4
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UVAZQQHAVMNMHE-XJKSGUPXSA-N alphaprodine Chemical compound C=1C=CC=CC=1[C@@]1(OC(=O)CC)CCN(C)C[C@@H]1C UVAZQQHAVMNMHE-XJKSGUPXSA-N 0.000 claims description 4
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IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims description 4
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208000002849 chondrocalcinosis Diseases 0.000 claims description 4
GPZLDQAEBHTMPG-UHFFFAOYSA-N clonitazene Chemical compound N=1C2=CC([N+]([O-])=O)=CC=C2N(CCN(CC)CC)C=1CC1=CC=C(Cl)C=C1 GPZLDQAEBHTMPG-UHFFFAOYSA-N 0.000 claims description 4
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LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 claims description 4
WDEFBBTXULIOBB-WBVHZDCISA-N dextilidine Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)OCC)CCC=C[C@H]1N(C)C WDEFBBTXULIOBB-WBVHZDCISA-N 0.000 claims description 4
229960003701 dextromoramide Drugs 0.000 claims description 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002652667A 2006-06-08 2007-06-06 Therapeutic combination for painful medical conditions Abandoned CA2652667A1 (en)

Applications Claiming Priority (15)

Application Number	Priority Date	Filing Date	Title
US81184006P	2006-06-08	2006-06-08
US81185906P	2006-06-08	2006-06-08
US60/811,859		2006-06-08
US60/811,840		2006-06-08
US11/506,523		2006-08-18
EPPCT/EP2006/008171		2006-08-18
US11/506577		2006-08-18
US11/506,577 US20070042969A1 (en)	2004-03-26	2006-08-18	Combination therapy for pain in painful diabetic neuropathy
US11/506,524 US20070043120A1 (en)	2005-08-18	2006-08-18	Therapeutic combination for painful medical conditions
US11/506,578 US20070048372A1 (en)	2005-08-18	2006-08-18	Method for treating non-inflammatory osteoarthritic pain
US11/506,523 US20070197657A1 (en)	2005-08-18	2006-08-18	Method for treating non-inflammatory musculoskeletal pain
US11/506524		2006-08-18
US11/506578		2006-08-18
PCT/EP2006/008171 WO2007020103A2 (en)	2005-08-18	2006-08-18	Novel use of peptide compounds for treating muscle pain
PCT/EP2007/005036 WO2007141018A1 (en)	2006-06-08	2007-06-06	Therapeutic combination for painful medical conditions

Publications (1)

Publication Number	Publication Date
CA2652667A1 true CA2652667A1 (en)	2007-12-13

Family

ID=46964866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002652667A Abandoned CA2652667A1 (en)	2006-06-08	2007-06-06	Therapeutic combination for painful medical conditions

Country Status (11)

Country	Link
JP (1)	JP2009539792A (de)
KR (1)	KR20090018863A (de)
AR (1)	AR061250A1 (de)
AT (1)	ATE530175T1 (de)
AU (1)	AU2007256352A1 (de)
BR (1)	BRPI0712494A2 (de)
CA (1)	CA2652667A1 (de)
EA (1)	EA200802412A1 (de)
MX (1)	MX2008015341A (de)
TW (1)	TW200814988A (de)
WO (1)	WO2007141018A1 (de)

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WO2014078956A1 (en)	2012-11-20	2014-05-30	Revive Therapeutics Inc.	The use of bucillamine in the treatment of gout
US9662305B2 (en)	2012-11-20	2017-05-30	Revive Therapeutics Inc.	Use of bucillamine in the treatment of gout

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TW200846003A (en) *	2007-03-15	2008-12-01	Astellas Pharma Inc	Novel prophylactic and/or therapeutic agent for diabetic neuropathy
TW200846002A (en) *	2007-03-15	2008-12-01	Astellas Pharma Inc	Novel prophylactic and/or therapeutic agent for diabetic neuropathy
EP2116539A1 (de)	2008-04-25	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon
KR20110071079A (ko) *	2008-09-11	2011-06-28	아스텔라스세이야쿠 가부시키가이샤	침해 수용성 동통의 신규 치료용 의약 조성물
US8198268B2 (en)	2008-10-31	2012-06-12	Janssen Biotech, Inc.	Tianeptine sulfate salt forms and methods of making and using the same
EP2353591A1 (de)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon
EP2353598A1 (de)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz
EP2388005A1 (de)	2010-05-21	2011-11-23	Laboratorios Del. Dr. Esteve, S.A.	Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie
RU2589692C2 (ru)	2010-06-15	2016-07-10	Грюненталь Гмбх	Фармацевтическая комбинация для лечения от боли
EP2415471A1 (de)	2010-08-03	2012-02-08	Laboratorios Del. Dr. Esteve, S.A.	Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie
EP2524694A1 (de) *	2011-05-19	2012-11-21	Laboratorios Del. Dr. Esteve, S.A.	Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes
TW201607538A (zh)	2013-12-17	2016-03-01	以斯提夫博士實驗室股份有限公司	血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物
US20200087390A1 (en)	2016-12-21	2020-03-19	Amgen Inc.	Anti-tnf alpha antibody formulations
TW202300138A (zh) *	2021-03-17	2023-01-01	大陸商上海博志研新藥物技術有限公司	拉考沙胺藥物組合物、其製備方法及應用
CN114306346A (zh) *	2021-12-14	2022-04-12	四川大学华西医院	拉莫三嗪在治疗系统性红斑狼疮中的应用

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EP1243262B1 (de) *	2001-03-20	2006-05-31	Schwarz Pharma Ag	Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
WO2005053667A1 (en) *	2003-12-02	2005-06-16	Schwarz Pharma Ag	Novel use of peptide compounds for treating central neuropathic pain
EP1579858A1 (de) *	2004-03-26	2005-09-28	Schwarz Pharma Ag	Neue Verwendung von Peptidverbindungen zur Behandlung von diabetishen Neuropathie
KR20070007931A (ko) *	2004-04-16	2007-01-16	쉬바르츠파르마에이지	만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1748776A1 (de) *	2004-05-03	2007-02-07	Duke University	Zusammensetzungen zur beeinflussung des gewichtsverlusts

2007
- 2007-06-06 AU AU2007256352A patent/AU2007256352A1/en not_active Abandoned
- 2007-06-06 MX MX2008015341A patent/MX2008015341A/es unknown
- 2007-06-06 WO PCT/EP2007/005036 patent/WO2007141018A1/en not_active Ceased
- 2007-06-06 EA EA200802412A patent/EA200802412A1/ru unknown
- 2007-06-06 JP JP2009513597A patent/JP2009539792A/ja active Pending
- 2007-06-06 CA CA002652667A patent/CA2652667A1/en not_active Abandoned
- 2007-06-06 AT AT07725884T patent/ATE530175T1/de not_active IP Right Cessation
- 2007-06-06 AR ARP070102440A patent/AR061250A1/es not_active Application Discontinuation
- 2007-06-06 KR KR1020097000247A patent/KR20090018863A/ko not_active Withdrawn
- 2007-06-06 BR BRPI0712494-5A patent/BRPI0712494A2/pt not_active IP Right Cessation
- 2007-06-07 TW TW096120539A patent/TW200814988A/zh unknown

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014078956A1 (en)	2012-11-20	2014-05-30	Revive Therapeutics Inc.	The use of bucillamine in the treatment of gout
US9238018B2 (en)	2012-11-20	2016-01-19	Revive Therapeutics Inc.	Use of bucillamine in the treatment of gout
US9662305B2 (en)	2012-11-20	2017-05-30	Revive Therapeutics Inc.	Use of bucillamine in the treatment of gout

Also Published As

Publication number	Publication date
AU2007256352A1 (en)	2007-12-13
BRPI0712494A2 (pt)	2012-10-09
TW200814988A (en)	2008-04-01
ATE530175T1 (de)	2011-11-15
WO2007141018A1 (en)	2007-12-13
AR061250A1 (es)	2008-08-13
JP2009539792A (ja)	2009-11-19
MX2008015341A (es)	2009-02-10
EA200802412A1 (ru)	2009-06-30
KR20090018863A (ko)	2009-02-23

Legal Events

Date	Code	Title	Description
2013-08-01	FZDE	Discontinued	Effective date: 20130606

Publication	Publication Date	Title
US20120225119A1 (en)	2012-09-06	Therapeutic combination for painful medical conditions
WO2007141018A1 (en)	2007-12-13	Therapeutic combination for painful medical conditions
US20070197657A1 (en)	2007-08-23	Method for treating non-inflammatory musculoskeletal pain
US20070048372A1 (en)	2007-03-01	Method for treating non-inflammatory osteoarthritic pain
US20070042969A1 (en)	2007-02-22	Combination therapy for pain in painful diabetic neuropathy
US20100256179A1 (en)	2010-10-07	Combination therapy for pain in painful diabetic neuropathy
JP5795145B2 (ja)	2015-10-14	難治性てんかん重積症の治療用ペプチド化合物
JP4977297B2 (ja)	2012-07-18	トラマドール物質及び抗痙攣薬を含んで成る組成物
BRPI0713994A2 (pt)	2012-11-20	compostos peptÍdicos para o tratamento de distérbios de hiperexcitabilidade e doenÇas associadas À disfunÇço do canal de Íons
JP2007507538A (ja)	2007-03-29	疼痛軽減方法
NZ551207A (en)	2010-07-30	Peptide compounds for the manufacture of medicaments for treating tremor syndromes
EP1423168A2 (de)	2004-06-02	Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
Hansen et al.	2004	The effects of intrathecal gabapentin on spinal morphine tolerance in the rat tail-flick and paw pressure tests
Ortiz et al.	2008	Examination of the interaction between peripheral lumiracoxib and opioids on the 1% formalin test in rats
CN101484152A (zh)	2009-07-15	用于疼痛性医学病症的治疗组合
EP2026788A1 (de)	2009-02-25	Therapeutische kombination für schmerzhafte medizinische zustände
BR112013000164B1 (pt)	2021-11-23	Agente terapêutico ou agente profilático
KR20080038408A (ko)	2008-05-06	근육통 치료를 위한 펩티드 화합물의 신규한 용도