CA2669913C - Endoxifen methods and compositions - Google Patents

Endoxifen methods and compositions Download PDF

Info

Publication number
CA2669913C
CA2669913C CA2669913A CA2669913A CA2669913C CA 2669913 C CA2669913 C CA 2669913C CA 2669913 A CA2669913 A CA 2669913A CA 2669913 A CA2669913 A CA 2669913A CA 2669913 C CA2669913 C CA 2669913C
Authority
CA
Canada
Prior art keywords
endoxifen
acid
use according
composition
cholesterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2669913A
Other languages
English (en)
French (fr)
Other versions
CA2669913A1 (en
Inventor
Ateeq Ahmad
Shoukath M. Ali
Moghis U. Ahmad
Saifuddin Sheikh
Imran Ahmad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jina Pharmaceuticals Inc
Original Assignee
Jina Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39492975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2669913(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jina Pharmaceuticals Inc filed Critical Jina Pharmaceuticals Inc
Publication of CA2669913A1 publication Critical patent/CA2669913A1/en
Application granted granted Critical
Publication of CA2669913C publication Critical patent/CA2669913C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2669913A 2006-11-21 2007-11-21 Endoxifen methods and compositions Active CA2669913C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86042006P 2006-11-21 2006-11-21
US60/860,420 2006-11-21
US86078806P 2006-11-22 2006-11-22
US60/860,788 2006-11-22
PCT/US2007/085443 WO2008070463A2 (en) 2006-11-21 2007-11-21 Endoxifen methods and compositions

Publications (2)

Publication Number Publication Date
CA2669913A1 CA2669913A1 (en) 2008-06-12
CA2669913C true CA2669913C (en) 2012-09-18

Family

ID=39492975

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2669913A Active CA2669913C (en) 2006-11-21 2007-11-21 Endoxifen methods and compositions

Country Status (11)

Country Link
US (2) US9333190B2 (2)
EP (1) EP2101731B1 (2)
JP (1) JP2010510327A (2)
CA (1) CA2669913C (2)
DK (1) DK2101731T3 (2)
ES (1) ES2665917T3 (2)
HU (1) HUE037109T2 (2)
IN (1) IN2014MN00139A (2)
PL (1) PL2101731T3 (2)
PT (1) PT2101731T (2)
WO (1) WO2008070463A2 (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090291134A1 (en) * 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
PT2101731T (pt) 2006-11-21 2018-04-18 Jina Pharmaceuticals Inc Endoxifeno para utilização no tratamento de cancro
PL3202420T3 (pl) * 2008-12-11 2020-07-13 Besins Healthcare Luxembourg Sarl Transdermalne kompozycje farmaceutyczne zawierające SERM
CA3024230C (en) 2011-04-28 2022-10-18 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
EP2668945A1 (de) 2012-06-01 2013-12-04 Bayer Technology Services GmbH Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen
WO2014065751A1 (en) * 2012-10-26 2014-05-01 Oncopeptides Ab Lyophilized preparations of melphalan flufenamide
WO2017011623A1 (en) * 2015-07-14 2017-01-19 Atossa Genetics Inc. Transpapillary methods and compositions for treating breast disorders
DE102015222031A1 (de) 2015-11-10 2017-05-11 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Synthese von (Z)-Endoxifenhydrochlorid
US20170304232A1 (en) * 2016-04-20 2017-10-26 Northwestern University Endoxifen For Local Transdermal Therapy To The Breast
CN111212631A (zh) * 2017-09-11 2020-05-29 阿托莎医疗公司 局部用组合物和治疗方法
TWI793165B (zh) 2017-09-11 2023-02-21 美商阿托薩醫療公司 製造及使用因多昔芬(endoxifen)之方法
MX2022000203A (es) * 2019-07-03 2022-03-22 Atossa Therapeutics Inc Composiciones de liberacion sostenida de endoxifeno.
US12245997B2 (en) 2020-04-10 2025-03-11 Jina Pharmaceuticals, Inc. Endoxifen for the treatment of bipolar I disorder
BR112022020320A2 (pt) 2020-04-10 2022-12-13 Jina Pharmaceuticals Inc Método para manter uma concentração terapeuticamente eficaz de endoxifeno para tratamento de um paciente com distúrbio bipolar i
US20220296514A1 (en) * 2021-03-18 2022-09-22 FormuRx Pharmaceuticals Co., Ltd. Composition and Method of Preparation for Lipid Formulations Comprising Charged Lipids
IL314075A (en) 2022-01-12 2024-09-01 Atossa Therapeutics Inc Compositions of (Z)-endoxifen and methods for their enrichment
KR20250002604A (ko) * 2022-04-26 2025-01-07 아토사 테라퓨틱스, 인크. 고용량 엔독시펜 제제 및 사용 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2817157A1 (de) * 1978-04-17 1979-10-25 Schering Ag Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie
ES2208687T3 (es) * 1994-08-04 2004-06-16 Elan Drug Delivery Limited Sistema de administracion de sustancias solidas para la liberacion controlada de moleculas incorporadas en tales sustancias y procedimientos para la fabricacion de tales sistemas.
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6090407A (en) * 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
JP5917789B2 (ja) 2006-10-10 2016-05-18 ジャイナ ファーマシューティカルズ，インコーポレーテッド 脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用
WO2008048194A1 (en) 2006-10-20 2008-04-24 Yesilogluj Aysegul Yildiz Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder
WO2008058156A2 (en) 2006-11-06 2008-05-15 Jina Pharmaceuticals Inc. Guggulphospholipid methods and compositions
PT2101731T (pt) 2006-11-21 2018-04-18 Jina Pharmaceuticals Inc Endoxifeno para utilização no tratamento de cancro
US20090291134A1 (en) 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
JP5720881B2 (ja) 2011-01-31 2015-05-20 東芝ライテック株式会社 Ｌｅｄランプ点灯装置および照明装置

Also Published As

Publication number Publication date
PT2101731T (pt) 2018-04-18
US10376479B2 (en) 2019-08-13
ES2665917T3 (es) 2018-04-30
DK2101731T3 (en) 2018-04-16
JP2010510327A (ja) 2010-04-02
WO2008070463A3 (en) 2008-11-06
EP2101731B1 (en) 2018-01-31
EP2101731A4 (en) 2011-04-20
PL2101731T3 (pl) 2018-07-31
HUE037109T2 (hu) 2018-08-28
US20160346230A1 (en) 2016-12-01
EP2101731A2 (en) 2009-09-23
IN2014MN00139A (2) 2015-06-19
US9333190B2 (en) 2016-05-10
WO2008070463A9 (en) 2008-09-18
CA2669913A1 (en) 2008-06-12
WO2008070463A2 (en) 2008-06-12
US20100112041A1 (en) 2010-05-06

Similar Documents

Publication Publication Date Title
US11672758B2 (en) Endoxifen methods and compositions for inhibition of protein kinase C
CA2669913C (en) Endoxifen methods and compositions
US20120164075A1 (en) Endoxifen methods and compositions in the treatment of mammalian diseases
EP1673063B1 (en) Transdermal pharmaceutical composition
JP3903061B2 (ja) 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤
JP5221343B2 (ja) 担体
JP5069131B2 (ja) 動物へのｎｄｇａ化合物を包含するカテコールブタンの注射のための製剤
CN106924176B (zh) 一种他莫昔芬柔性纳米脂质体凝胶剂及其制备方法
CN102159202A (zh) 施用局部抗真菌制剂治疗真菌感染的方法
CN121489917A (zh) 用于皮下注射的氯胺酮制剂
TW201247613A (en) Ester derivatives of bimatoprost compositions and methods
WO2015117136A1 (en) Boronic acid esters and pharmaceutical formulations thereof
JP5489407B2 (ja) ４−ヒドロキシタモキシフェンの化学的に安定な組成物
CN104706597A (zh) 一种用于鼻腔给药的尼莫地平脂质体及其制备方法
WO2022003443A1 (ko) 양이온성 리포좀을 포함하는 사포닌의 용혈 억제용 조성물
HK1136198A (en) Endoxifen for use in the treatment of cancer
HK1136198B (en) Endoxifen for use in the treatment of cancer
WO2017107895A1 (zh) 口服制剂及其制备方法
CN101150956B (zh) 用于注射入动物的包括ndga化合物的儿茶酚丁烷配方
TW202448515A (zh) 汰癌勝結合物化合物、組成物、及其等的使用方法
JP2007535505A (ja) ４−ヒドロキシタモキシフェンを用いた良性乳房疾患の治療および予防

Legal Events

Date Code Title Description
EEER Examination request