CA2677611C - Systemes hybrides organiques/inorganiques, comprenant des systemes hybrides de phosphate de calcium fonctionnalise, et un procede de production a l'etat solide de tels systemes - Google Patents

Systemes hybrides organiques/inorganiques, comprenant des systemes hybrides de phosphate de calcium fonctionnalise, et un procede de production a l'etat solide de tels systemes Download PDF

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Publication number
CA2677611C
CA2677611C CA2677611A CA2677611A CA2677611C CA 2677611 C CA2677611 C CA 2677611C CA 2677611 A CA2677611 A CA 2677611A CA 2677611 A CA2677611 A CA 2677611A CA 2677611 C CA2677611 C CA 2677611C
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Prior art keywords
organic
vessel
particles
tricalcium phosphate
inorganic
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CA2677611A
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CA2677611A1 (fr
Inventor
Robert L. Karlinsey
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INDIANA NANOTECH DIVISION OF THERAMETRIC TECHNOLOGIES Inc
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INDIANA NANOTECH DIVISION OF THERAMETRIC TECHNOLOGIES Inc
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23C—MILLING
    • B23C2220/00—Details of milling processes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F11/00—Compounds of calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C08K2003/321—Phosphates
    • C08K2003/325—Calcium, strontium or barium phosphate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T409/00—Gear cutting, milling, or planing
    • Y10T409/30—Milling

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cosmetics (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé de production à l'état solide de fractions fonctionnalisées, comprenant le placement de quantités prédéterminées de matières organiques et inorganiques et un milieu de broyage dans une cuve reliée en rotation à une plate-forme tournante, d'une quantité de matière organique dans la cuve, la rotation de la cuve dans une première direction en faisant tourner la plate-forme tournante dans une seconde direction opposée à la première direction, le broyage des matières organiques et inorganiques en de plus petites particules organiques et inorganiques respectives, et la fusion de portions de particules organiques et de particules inorganiques pour définir des fraction fonctionnalisées. La matière inorganique peut inclure des phosphates de calcium de phase, de structure, et de composition variées. La matière organique peut inclure des tensioactifs anioniques, des tensioactifs cationiques, des tensioactifs neutres, des acides carboxyliques, des polymères, des copolymères, des copolymères blocs, et leurs combinaisons.
CA2677611A 2007-02-06 2008-01-23 Systemes hybrides organiques/inorganiques, comprenant des systemes hybrides de phosphate de calcium fonctionnalise, et un procede de production a l'etat solide de tels systemes Active CA2677611C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US88835407P 2007-02-06 2007-02-06
US60/888,354 2007-02-06
US89184907P 2007-02-27 2007-02-27
US60/891,849 2007-02-27
US94109507P 2007-05-31 2007-05-31
US60/941,095 2007-05-31
PCT/US2008/051795 WO2008137190A2 (fr) 2007-02-06 2008-01-23 Systèmes hybrides organiques/inorganiques, comprenant des systèmes hybrides de phosphate de calcium fonctionnalisé, et un procédé de production à l'état solide de tels systèmes

Publications (2)

Publication Number Publication Date
CA2677611A1 CA2677611A1 (fr) 2008-11-13
CA2677611C true CA2677611C (fr) 2017-08-29

Family

ID=39676342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2677611A Active CA2677611C (fr) 2007-02-06 2008-01-23 Systemes hybrides organiques/inorganiques, comprenant des systemes hybrides de phosphate de calcium fonctionnalise, et un procede de production a l'etat solide de tels systemes

Country Status (7)

Country Link
US (2) US8556553B2 (fr)
EP (1) EP2120842B1 (fr)
AU (1) AU2008248087B2 (fr)
BR (1) BRPI0807003A2 (fr)
CA (1) CA2677611C (fr)
MX (1) MX2009008331A (fr)
WO (1) WO2008137190A2 (fr)

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WO2006055327A1 (fr) * 2004-11-16 2006-05-26 3M Innovative Properties Company Charges dentaires et compositions incluant des sels de phosphate
EP2260828B1 (fr) 2004-11-16 2015-08-05 3M Innovative Properties Co. Charges dentaires, procédés, compositions incluant un caseinate
US10130561B2 (en) * 2006-01-31 2018-11-20 Robert L. Karlinsey Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications
US9023373B2 (en) * 2007-01-31 2015-05-05 Indiana Nanotech Functionalized calcium phosphate hybrid systems for the remineralization of teeth and a method for producing the same
US9205036B2 (en) 2007-01-31 2015-12-08 Robert Karlinsey Dental composition
BRPI0807003A2 (pt) 2007-02-06 2014-04-15 Indiana Nanotech Division Of Therametric Technologies Inc Sistemas químicos orgânicos/inorgânicos híbridos, incluindo sistemas híbridos de fosfato de cálcio funcionalizados, e um método de estado sólido para produzir os mesmos
US8568696B2 (en) * 2008-08-06 2013-10-29 Indiana Nanotech Llc Grinding method for the manipulation or preservation of calcium phosphate hybrid properties
US8603441B2 (en) * 2008-09-12 2013-12-10 Indiana Nanotech Llc Functionalized calcium phosphate hybrid systems for confectionery and foodstuff applications
WO2010068359A1 (fr) 2008-12-11 2010-06-17 3M Innovative Properties Company Particules de phosphate de calcium traitées en surface pour soins buccaux et compositions dentaires
US8632754B2 (en) 2009-08-03 2014-01-21 Mcneil-Ppc, Inc. Tooth sensitivity treatment compositions
US9060947B2 (en) 2009-08-03 2015-06-23 Mcneil-Ppc, Inc. Tooth sensitivity treatment compositions
US8603442B2 (en) 2009-08-03 2013-12-10 Mcneil-Ppc, Inc. Tooth sensitivity treatment compositions
WO2013095366A1 (fr) 2011-12-20 2013-06-27 Colgate-Palmolive Company Compositions d'hygiène orale
US9107838B2 (en) 2012-04-25 2015-08-18 Therametrics Technologies, Inc. Fluoride varnish
WO2014124950A1 (fr) 2013-02-14 2014-08-21 Glaxo Group Limited Nouvelle composition
BR112018074268B1 (pt) 2016-05-26 2022-04-19 3M Innovative Properties Company Pasta dental, kit para tratamento de uma superfície na cavidade oral de um indivíduo, e uso
WO2018204795A1 (fr) * 2017-05-04 2018-11-08 Phoenix Dental, Inc. Composition et procédé dentaires
CN108853023B (zh) * 2018-07-05 2021-11-30 广州立白企业集团有限公司 口腔抑菌组合物及其制备方法与应用
EP4034077A1 (fr) 2019-09-26 2022-08-03 3M Innovative Properties Company Composition de soin buccal contenant des composants de sulfonate ou de carbonate d'alkyle d'ammonium pour le traitement des caries
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Also Published As

Publication number Publication date
CA2677611A1 (fr) 2008-11-13
EP2120842A4 (fr) 2014-10-08
US8556553B2 (en) 2013-10-15
US20080187500A1 (en) 2008-08-07
MX2009008331A (es) 2010-03-22
BRPI0807003A2 (pt) 2014-04-15
AU2008248087A1 (en) 2008-11-13
WO2008137190A3 (fr) 2008-12-31
EP2120842A2 (fr) 2009-11-25
US20120114718A1 (en) 2012-05-10
EP2120842B1 (fr) 2019-08-21
WO2008137190A2 (fr) 2008-11-13
AU2008248087B2 (en) 2013-03-28

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