CA2710618C - Synthese d'iodixanol dans le methanol - Google Patents

Synthese d'iodixanol dans le methanol Download PDF

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Publication number
CA2710618C
CA2710618C CA2710618A CA2710618A CA2710618C CA 2710618 C CA2710618 C CA 2710618C CA 2710618 A CA2710618 A CA 2710618A CA 2710618 A CA2710618 A CA 2710618A CA 2710618 C CA2710618 C CA 2710618C
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Canada
Prior art keywords
iodixanol
compound
dimerisation
methanol
bis
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Active
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CA2710618A
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English (en)
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CA2710618A1 (fr
Inventor
Hanne Jorunn H. Johnsen
Lars Terje Holmaas
Ole Magne Homestad
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GE Healthcare AS
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GE Healthcare AS
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Priority claimed from US12/621,551 external-priority patent/US8962886B2/en
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Publication of CA2710618C publication Critical patent/CA2710618C/fr
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Abstract

La présente invention a trait à la synthèse de liodixanol (1,3-bis[acétamido]-N,N- bis[3,5-bis[2,3- dihydroxypropylaminocarbonyl]-2,4,6-triiodophényle]-2-hydroxypropane), plus particulièrement à la dimérisation de 5-acétamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- isophthalamide avec du méthanol comme solvant.
CA2710618A 2009-07-21 2010-07-20 Synthese d'iodixanol dans le methanol Active CA2710618C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22709509P 2009-07-21 2009-07-21
US61/227,095 2009-07-21
US12/621,551 US8962886B2 (en) 2009-07-21 2009-11-19 Synthesis of iodixanol in methanol
US12/621,551 2009-11-19

Publications (2)

Publication Number Publication Date
CA2710618A1 CA2710618A1 (fr) 2011-01-21
CA2710618C true CA2710618C (fr) 2017-07-18

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ID=43495955

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710618A Active CA2710618C (fr) 2009-07-21 2010-07-20 Synthese d'iodixanol dans le methanol

Country Status (1)

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CA (1) CA2710618C (fr)

Also Published As

Publication number Publication date
CA2710618A1 (fr) 2011-01-21

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