CA2729546A1 - Compounds and compositions as kinase inhibitors - Google Patents

Compounds and compositions as kinase inhibitors Download PDF

Info

Publication number: CA2729546A1
Authority: CA; Canada
Prior art keywords: 6alkyl; compound; methyl; halo; pyrazol
Prior art date: 2008-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2729546A

Other languages

English (en)

French (fr)

Inventor

Thomas H. Marsilje, Iii

Wenshuo Lu

Bei Chen

Xiaohui He

Songchun Jiang

Kunyong Yang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

IRM LLC

Original Assignee

IRM LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-25

Filing date

2009-06-24

Publication date

2009-12-30

2009-06-24 Application filed by IRM LLC filed Critical IRM LLC

2009-12-30 Publication of CA2729546A1 publication Critical patent/CA2729546A1/en

Status Abandoned legal-status Critical Current

Links

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NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2729546A 2008-06-25 2009-06-24 Compounds and compositions as kinase inhibitors Abandoned CA2729546A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7558308P	2008-06-25	2008-06-25
US61/075,583		2008-06-25
PCT/US2009/048509 WO2009158431A2 (en)	2008-06-25	2009-06-24	Compounds and compositions as kinase inhibitors

Publications (1)

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CA2729546A1 true CA2729546A1 (en)	2009-12-30

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EP (1)	EP2331526A2 (pt)
JP (1)	JP2011526291A (pt)
KR (1)	KR20110020940A (pt)
CN (1)	CN102203083A (pt)
AU (1)	AU2009262198B2 (pt)
BR (1)	BRPI0914545A2 (pt)
CA (1)	CA2729546A1 (pt)
EA (1)	EA201100078A1 (pt)
MX (1)	MX2010014568A (pt)
UA (1)	UA101057C2 (pt)
WO (1)	WO2009158431A2 (pt)

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EP2544672A1 (en)	2010-03-09	2013-01-16	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
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CN104854101B (zh)	2012-11-06	2018-05-01	上海复尚慧创医药研究有限公司	Alk激酶抑制剂
MX394360B (es) *	2013-03-14	2025-03-24	Sumitomo Pharma Oncology Inc	Inhibidores de jak2 y alk2 y metodos para su uso.
AU2015266453C1 (en) *	2014-05-30	2018-09-13	Shanghai Emerald Wellcares Pharmaceutical Co., Ltd	Alk kinase inhibitor, and preparation method and use thereof
EP3523289A1 (en) *	2016-10-07	2019-08-14	Araxes Pharma LLC	Heterocyclic compounds as inhibitors of ras and methods of use thereof
CN107488148A (zh) *	2017-06-26	2017-12-19	安徽省黄淮兽药有限公司	一种苯丙酰胺类杀虫剂及其制备方法
WO2019126731A1 (en)	2017-12-22	2019-06-27	Petra Pharma Corporation	Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
TW202045008A (zh) *	2019-02-01	2020-12-16	印度商皮埃企業有限公司	4-取代的異噁唑/異噁唑啉(雜)芳基脒化合物、及其製備與用途
TW202112767A (zh)	2019-06-17	2021-04-01	美商佩特拉製藥公司	作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
KR20220153581A (ko) *	2020-02-14	2022-11-18	솔크 인스티튜트 포 바이올로지칼 스터디즈	Ulk1/2 의 억제제 및 이의 사용 방법
KR20220153582A (ko)	2020-02-14	2022-11-18	솔크 인스티튜트 포 바이올로지칼 스터디즈	마크로시클릭 ulk1/2 억제제

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ATE506953T1 (de) *	2003-08-07	2011-05-15	Rigel Pharmaceuticals Inc	2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel
GB0321710D0 (en) *	2003-09-16	2003-10-15	Novartis Ag	Organic compounds
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JP5328816B2 (ja) *	2008-02-22	2013-10-30	エフ．ホフマン−ラロシュアーゲー	アミロイドβの調節薬

2009
- 2009-06-24 AU AU2009262198A patent/AU2009262198B2/en not_active Expired - Fee Related
- 2009-06-24 EA EA201100078A patent/EA201100078A1/ru unknown
- 2009-06-24 CA CA2729546A patent/CA2729546A1/en not_active Abandoned
- 2009-06-24 BR BRPI0914545A patent/BRPI0914545A2/pt not_active IP Right Cessation
- 2009-06-24 MX MX2010014568A patent/MX2010014568A/es not_active Application Discontinuation
- 2009-06-24 EP EP09770964A patent/EP2331526A2/en not_active Withdrawn
- 2009-06-24 KR KR1020117001749A patent/KR20110020940A/ko not_active Ceased
- 2009-06-24 CN CN200980129584XA patent/CN102203083A/zh active Pending
- 2009-06-24 WO PCT/US2009/048509 patent/WO2009158431A2/en not_active Ceased
- 2009-06-24 UA UAA201104068A patent/UA101057C2/ru unknown
- 2009-06-24 JP JP2011516619A patent/JP2011526291A/ja not_active Ceased

Also Published As

Publication number	Publication date
WO2009158431A3 (en)	2010-03-11
EA201100078A1 (ru)	2011-08-30
KR20110020940A (ko)	2011-03-03
AU2009262198A1 (en)	2009-12-30
MX2010014568A (es)	2011-03-29
WO2009158431A2 (en)	2009-12-30
CN102203083A (zh)	2011-09-28
UA101057C2 (en)	2013-02-25
AU2009262198B2 (en)	2012-09-27
JP2011526291A (ja)	2011-10-06
EP2331526A2 (en)	2011-06-15
BRPI0914545A2 (pt)	2017-05-23

Legal Events

Date	Code	Title	Description
2010-12-24	EEER	Examination request
2014-06-23	FZDE	Discontinued	Effective date: 20140428

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AU2009233963B2 (en)	2011-10-06	Compounds and compositions as kinase inhibitors
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