CA2735477C - Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases - Google Patents

Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases Download PDF

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Publication number
CA2735477C
CA2735477C CA2735477A CA2735477A CA2735477C CA 2735477 C CA2735477 C CA 2735477C CA 2735477 A CA2735477 A CA 2735477A CA 2735477 A CA2735477 A CA 2735477A CA 2735477 C CA2735477 C CA 2735477C
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compound according
group
single bond
compound
aryl group
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English (en)
French (fr)
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CA2735477A1 (en
Inventor
Philip Wilson Howard
Stephen John Gregson
Luke Masterson
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MedImmune Ltd
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA2735477A 2008-10-17 2009-10-16 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases Active CA2735477C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0819095.1A GB0819095D0 (en) 2008-10-17 2008-10-17 Pyrrolobenzodiazepines
GB0819095.1 2008-10-17
PCT/GB2009/002498 WO2010043880A1 (en) 2008-10-17 2009-10-16 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
CA2735477A1 CA2735477A1 (en) 2010-04-22
CA2735477C true CA2735477C (en) 2016-10-04

Family

ID=40097621

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2735477A Active CA2735477C (en) 2008-10-17 2009-10-16 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases

Country Status (23)

Country Link
US (3) US8592576B2 (2)
EP (1) EP2350080B1 (2)
JP (2) JP5995441B2 (2)
KR (1) KR101755722B1 (2)
CN (3) CN102186855A (2)
AU (1) AU2009305190B2 (2)
BR (1) BRPI0918476B8 (2)
CA (1) CA2735477C (2)
CY (1) CY1117106T1 (2)
DK (1) DK2350080T3 (2)
ES (1) ES2557283T3 (2)
GB (1) GB0819095D0 (2)
HR (1) HRP20160003T1 (2)
HU (1) HUE025905T2 (2)
IL (1) IL211985A (2)
MX (1) MX2011003342A (2)
NZ (1) NZ591425A (2)
PL (1) PL2350080T3 (2)
PT (1) PT2350080E (2)
SI (1) SI2350080T1 (2)
SM (1) SMT201600017B (2)
WO (1) WO2010043880A1 (2)
ZA (1) ZA201101425B (2)

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