CA2751275A1 - Use of docosahexaenoic acid in treating mild cognitive impairment - Google Patents

Use of docosahexaenoic acid in treating mild cognitive impairment Download PDF

Info

Publication number: CA2751275A1
Authority: CA; Canada
Prior art keywords: dha; acid; less; unit dose; per day
Prior art date: 2009-02-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2751275A

Other languages

English (en)

French (fr)

Inventor

Karin Yurko-Mauro

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DSM IP Assets BV

Original Assignee

Martek Biosciences Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-02

Filing date

2010-02-02

Publication date

2010-08-05

2010-02-02 Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp

2010-08-05 Publication of CA2751275A1 publication Critical patent/CA2751275A1/en

Status Abandoned legal-status Critical Current

Links

235000020669 docosahexaenoic acid Nutrition 0.000 title claims abstract description 394
208000010877 cognitive disease Diseases 0.000 title claims abstract description 45
208000027061 mild cognitive impairment Diseases 0.000 title claims abstract description 26
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JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims abstract description 64
JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims abstract description 63
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IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 44
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229950005856 tocofibrate Drugs 0.000 description 1
VPRFDABTJNLKKR-XHZSPPMBSA-N tocofibrate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 VPRFDABTJNLKKR-XHZSPPMBSA-N 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
229950007110 trecetilide Drugs 0.000 description 1
229960004813 trichlormethiazide Drugs 0.000 description 1
LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
125000006000 trichloroethyl group Chemical group 0.000 description 1
125000005457 triglyceride group Chemical group 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
229960004699 valsartan Drugs 0.000 description 1
SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
239000001993 wax Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
229940002552 xenical Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
229960002769 zofenopril Drugs 0.000 description 1
DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)

CA2751275A 2009-02-02 2010-02-02 Use of docosahexaenoic acid in treating mild cognitive impairment Abandoned CA2751275A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US14931009P	2009-02-02	2009-02-02
US61/149,310		2009-02-02
US18354809P	2009-06-02	2009-06-02
US61/183,548		2009-06-02
PCT/US2010/022952 WO2010088700A1 (en)	2009-02-02	2010-02-02	Methods for improving cognitive function and decreasing heart rate

Publications (1)

Publication Number	Publication Date
CA2751275A1 true CA2751275A1 (en)	2010-08-05

Family

ID=42041547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2751275A Abandoned CA2751275A1 (en)	2009-02-02	2010-02-02	Use of docosahexaenoic acid in treating mild cognitive impairment

Country Status (8)

Country	Link
US (2)	US20100203123A1 (2)
EP (2)	EP2391361A1 (2)
JP (5)	JP2012516852A (2)
CN (3)	CN102365087A (2)
AU (2)	AU2016201382A1 (2)
CA (1)	CA2751275A1 (2)
HK (1)	HK1202243A1 (2)
WO (1)	WO2010088700A1 (2)

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2010
- 2010-02-02 CA CA2751275A patent/CA2751275A1/en not_active Abandoned
- 2010-02-02 CN CN2010800157224A patent/CN102365087A/zh active Pending
- 2010-02-02 JP JP2011548414A patent/JP2012516852A/ja not_active Withdrawn
- 2010-02-02 EP EP10703592A patent/EP2391361A1/en not_active Withdrawn
- 2010-02-02 CN CN201810349154.XA patent/CN108324706A/zh active Pending
- 2010-02-02 CN CN201410152946.XA patent/CN104042600A/zh active Pending
- 2010-02-02 EP EP15162676.9A patent/EP2939671A1/en not_active Withdrawn
- 2010-02-02 US US12/699,009 patent/US20100203123A1/en not_active Abandoned
- 2010-02-02 WO PCT/US2010/022952 patent/WO2010088700A1/en not_active Ceased
2012
- 2012-12-13 US US13/713,980 patent/US20130172412A1/en not_active Abandoned
2015
- 2015-03-17 HK HK15102730.4A patent/HK1202243A1/xx unknown
- 2015-03-20 JP JP2015057637A patent/JP2015143248A/ja active Pending
2016
- 2016-03-03 AU AU2016201382A patent/AU2016201382A1/en not_active Abandoned
2017
- 2017-10-10 AU AU2017245327A patent/AU2017245327A1/en not_active Abandoned
2018
- 2018-04-05 JP JP2018073345A patent/JP2018104477A/ja active Pending
2019
- 2019-12-27 JP JP2019238726A patent/JP2020050675A/ja active Pending
2022
- 2022-02-17 JP JP2022023007A patent/JP2022059063A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP2939671A1 (en)	2015-11-04
US20100203123A1 (en)	2010-08-12
EP2391361A1 (en)	2011-12-07
AU2016201382A1 (en)	2016-03-24
JP2020050675A (ja)	2020-04-02
CN104042600A (zh)	2014-09-17
CN108324706A (zh)	2018-07-27
JP2015143248A (ja)	2015-08-06
US20130172412A1 (en)	2013-07-04
AU2010207929A1 (en)	2011-09-22
JP2012516852A (ja)	2012-07-26
HK1202243A1 (en)	2015-09-25
JP2018104477A (ja)	2018-07-05
JP2022059063A (ja)	2022-04-12
AU2017245327A1 (en)	2017-11-02
WO2010088700A1 (en)	2010-08-05
CN102365087A (zh)	2012-02-29

Legal Events

Date	Code	Title	Description
2015-02-17	EEER	Examination request	Effective date: 20150130
2019-03-18	FZDE	Discontinued	Effective date: 20190204

Publication	Publication Date	Title
EP2939671A1 (en)	2015-11-04	Methods for improving cognitive function and decreasing heart rate
US11413263B2 (en)	2022-08-16	Reducing the risk of pathological effects of traumatic brain injury
US20100130608A1 (en)	2010-05-27	Compositions and methods for reducing triglyceride levels
JP6307442B2 (ja)	2018-04-04	対象の高感度（ｈｓ−ｃｒｐ）のレベルを低下させる組成物および方法
US20110086914A1 (en)	2011-04-14	Methods for Treating Traumatic Brain Injury
WO2011097273A1 (en)	2011-08-11	Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
US20130137767A1 (en)	2013-05-30	Methods and Compositions for Treating Arthritis with Docosahexaenoic Acid
US20110177061A1 (en)	2011-07-21	Methods of treating and preventing neurological disorders using docosahexaenoic acid
AU2010207929B2 (en)	2016-03-31	Methods for improving cognitive function and decreasing heart rate
US20110082205A1 (en)	2011-04-07	Docosahexaenoic Acid Gel Caps
HK1172241B (en)	2018-07-13	Reducing the risk of pathological effects of traumatic brain injury
HK1172241A (en)	2013-04-19	Reducing the risk of pathological effects of traumatic brain injury