CA2804592C - Procede de formation de matrices de tissu - Google Patents
Procede de formation de matrices de tissu Download PDFInfo
- Publication number
- CA2804592C CA2804592C CA2804592A CA2804592A CA2804592C CA 2804592 C CA2804592 C CA 2804592C CA 2804592 A CA2804592 A CA 2804592A CA 2804592 A CA2804592 A CA 2804592A CA 2804592 C CA2804592 C CA 2804592C
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- matrix
- tissue matrix
- radiation
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 68
- 238000007493 shaping process Methods 0.000 title claims abstract description 14
- 238000010382 chemical cross-linking Methods 0.000 claims abstract description 9
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 8
- 210000001519 tissue Anatomy 0.000 claims description 417
- 239000011159 matrix material Substances 0.000 claims description 189
- 108010035532 Collagen Proteins 0.000 claims description 66
- 102000008186 Collagen Human genes 0.000 claims description 66
- 229920001436 collagen Polymers 0.000 claims description 66
- 230000005855 radiation Effects 0.000 claims description 53
- 239000000835 fiber Substances 0.000 claims description 46
- 230000002500 effect on skin Effects 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 230000036425 denaturation Effects 0.000 claims description 18
- 238000004925 denaturation Methods 0.000 claims description 18
- 230000008569 process Effects 0.000 claims description 18
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 15
- 230000018044 dehydration Effects 0.000 claims description 13
- 238000006297 dehydration reaction Methods 0.000 claims description 13
- 230000035699 permeability Effects 0.000 claims description 13
- 210000003195 fascia Anatomy 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 7
- 210000002808 connective tissue Anatomy 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- 210000003932 urinary bladder Anatomy 0.000 claims description 7
- 241001269524 Dura Species 0.000 claims description 6
- 210000003709 heart valve Anatomy 0.000 claims description 6
- 210000003041 ligament Anatomy 0.000 claims description 6
- 210000002435 tendon Anatomy 0.000 claims description 6
- 230000000968 intestinal effect Effects 0.000 claims description 5
- 210000000626 ureter Anatomy 0.000 claims description 5
- 230000001537 neural effect Effects 0.000 claims description 4
- 210000005059 placental tissue Anatomy 0.000 claims description 4
- 210000003954 umbilical cord Anatomy 0.000 claims description 4
- 230000000087 stabilizing effect Effects 0.000 claims description 3
- 230000004071 biological effect Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 36
- 210000004027 cell Anatomy 0.000 description 25
- 239000000243 solution Substances 0.000 description 22
- 210000001367 artery Anatomy 0.000 description 16
- 239000002953 phosphate buffered saline Substances 0.000 description 13
- 238000009792 diffusion process Methods 0.000 description 12
- 230000001413 cellular effect Effects 0.000 description 11
- 238000004132 cross linking Methods 0.000 description 11
- 210000004207 dermis Anatomy 0.000 description 11
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 10
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 10
- 210000002744 extracellular matrix Anatomy 0.000 description 10
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 239000007943 implant Substances 0.000 description 9
- 238000001878 scanning electron micrograph Methods 0.000 description 9
- 210000000481 breast Anatomy 0.000 description 8
- 229960003964 deoxycholic acid Drugs 0.000 description 8
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 8
- 238000001757 thermogravimetry curve Methods 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 102000016911 Deoxyribonucleases Human genes 0.000 description 7
- 108010053770 Deoxyribonucleases Proteins 0.000 description 7
- 241000288906 Primates Species 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000011888 foil Substances 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 6
- 230000002792 vascular Effects 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 239000002985 plastic film Substances 0.000 description 5
- 229920006255 plastic film Polymers 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010023728 Alloderm Proteins 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
- 238000001493 electron microscopy Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 238000002073 fluorescence micrograph Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229960002518 gentamicin Drugs 0.000 description 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940050561 matrix product Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 230000036573 scar formation Effects 0.000 description 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000002689 xenotransplantation Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102100021587 Embryonic testis differentiation protein homolog A Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 238000006424 Flood reaction Methods 0.000 description 1
- 241000699694 Gerbillinae Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241001272567 Hominoidea Species 0.000 description 1
- 101000898120 Homo sapiens Embryonic testis differentiation protein homolog A Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288935 Platyrrhini Species 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 210000004504 adult stem cell Anatomy 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 239000012984 antibiotic solution Substances 0.000 description 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000002358 autolytic effect Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 150000001720 carbohydrates Chemical group 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001938 differential scanning calorimetry curve Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 108010006205 fluorescein isothiocyanate bovine serum albumin Proteins 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000011824 nuclear material Substances 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000007826 nucleic acid assay Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000000050 smooth muscle relaxant Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N trihydridoboron Substances B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/18—Internal ear or nose parts, e.g. ear-drums
- A61F2/186—Nose parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
La présente invention concerne des procédés de formation de matrices de tissu. Lesdits procédés peuvent être utilisés pour produire des produits de tissu profilés qui conservent des propriétés biologiques souhaitées sans l'utilisation d'agents chimiques de réticulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3054722A CA3054722A1 (fr) | 2010-07-08 | 2011-07-07 | Procede de formation de matrices de tissu |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36242410P | 2010-07-08 | 2010-07-08 | |
| US61/362,424 | 2010-07-08 | ||
| PCT/US2011/043129 WO2012006390A1 (fr) | 2010-07-08 | 2011-07-07 | Procédé de formation de matrices de tissu |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3054722A Division CA3054722A1 (fr) | 2010-07-08 | 2011-07-07 | Procede de formation de matrices de tissu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2804592A1 CA2804592A1 (fr) | 2012-01-12 |
| CA2804592C true CA2804592C (fr) | 2019-10-29 |
Family
ID=44629331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3054722A Abandoned CA3054722A1 (fr) | 2010-07-08 | 2011-07-07 | Procede de formation de matrices de tissu |
| CA2804592A Expired - Fee Related CA2804592C (fr) | 2010-07-08 | 2011-07-07 | Procede de formation de matrices de tissu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3054722A Abandoned CA3054722A1 (fr) | 2010-07-08 | 2011-07-07 | Procede de formation de matrices de tissu |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9636435B2 (fr) |
| EP (2) | EP3581211A1 (fr) |
| JP (1) | JP5967721B2 (fr) |
| CN (1) | CN103068413B (fr) |
| AU (1) | AU2011276246B2 (fr) |
| CA (2) | CA3054722A1 (fr) |
| ES (1) | ES2759445T3 (fr) |
| WO (1) | WO2012006390A1 (fr) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8469779B1 (en) | 2009-01-02 | 2013-06-25 | Lifecell Corporation | Method for debristling animal skin |
| US8986377B2 (en) | 2009-07-21 | 2015-03-24 | Lifecell Corporation | Graft materials for surgical breast procedures |
| EP2696908B1 (fr) | 2011-04-14 | 2015-03-11 | Lifecell Corporation | Matériaux régénératifs |
| US9089523B2 (en) | 2011-07-28 | 2015-07-28 | Lifecell Corporation | Natural tissue scaffolds as tissue fillers |
| US9549805B2 (en) | 2011-12-20 | 2017-01-24 | Lifecell Corporation | Flowable tissue products |
| EP3842078A1 (fr) | 2011-12-20 | 2021-06-30 | LifeCell Corporation | Produits de tissu en feuille |
| ES2812281T3 (es) * | 2012-01-13 | 2021-03-16 | Lifecell Corp | Métodos para fabricar prótesis mamarias |
| EP2806907B1 (fr) | 2012-01-24 | 2018-11-21 | LifeCell Corporation | Matrices tissulaires allongées |
| BR112014026090A8 (pt) | 2012-04-24 | 2019-08-27 | Lifecell Corp | composição de matriz tecidual apta a fluir |
| KR20150015532A (ko) * | 2012-05-30 | 2015-02-10 | 뉴욕 유니버시티 | 조직 수복 장치 및 스캐폴드 |
| US10363343B2 (en) | 2012-07-05 | 2019-07-30 | Lifecell Corporation | Tissue-based drain manifolds |
| EP3777906A1 (fr) * | 2012-07-06 | 2021-02-17 | LifeCell Corporation | Matrice musculaire décellularisée |
| US11090338B2 (en) | 2012-07-13 | 2021-08-17 | Lifecell Corporation | Methods for improved treatment of adipose tissue |
| EP3332816B1 (fr) | 2012-09-26 | 2020-11-04 | LifeCell Corporation | Tissu adipeux traité |
| US20150374881A1 (en) * | 2012-12-27 | 2015-12-31 | Nitta Gelatin Inc. | Human corneal endothelial cell sheet |
| EP3659633A1 (fr) | 2013-02-06 | 2020-06-03 | LifeCell Corporation | Procédés pour modification localisée de produits tissulaires |
| WO2014160008A1 (fr) | 2013-03-14 | 2014-10-02 | Musculoskeletal Transplant Foundation | Allogreffes de réparation de tissu mou et procédé pour préparer celles-ci |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| CN103393482B (zh) | 2013-08-14 | 2016-04-06 | 北京瑞健高科生物科技有限公司 | 一种基于组织基质材料的乳房假体支撑装置及其制备方法 |
| US10173375B2 (en) | 2014-03-05 | 2019-01-08 | Bacterin International, Inc. | Shaped fiber-based products and method of manufacture thereof |
| CA3164644A1 (en) * | 2014-08-07 | 2016-02-11 | Memorial Sloan-Kettering Cancer Center | Tissue array using a carrier medium and method for providing the same |
| BR112017019431B1 (pt) * | 2015-03-12 | 2022-11-08 | G & G Biotechnology Ltd | Implante proteico com um compósito de um material de base e um material aditivo |
| US10821004B2 (en) | 2015-06-30 | 2020-11-03 | Bacterin Interational, Inc. | Expandable bone grafts and methods of manufacture thereof |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US10413635B2 (en) * | 2015-08-17 | 2019-09-17 | Vivex Biomedical, Inc. | Umbilical cord transplant product |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| EP3337427A1 (fr) | 2015-08-21 | 2018-06-27 | Lifecell Corporation | Dispositif de traitement du sein |
| US10537665B2 (en) * | 2015-09-11 | 2020-01-21 | Lifecell Corporation | Perforated tissue matrix |
| WO2017075608A1 (fr) | 2015-10-30 | 2017-05-04 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Timbre de manchon de suture et procédés de pose dans un flux de travail arthroscopique existant |
| CN106913907B (zh) * | 2015-12-25 | 2022-04-05 | 北京瑞健高科生物科技有限公司 | 一种具有结构记忆特性的细胞生长支架的制备方法 |
| CN106913908B (zh) * | 2015-12-25 | 2020-05-26 | 北京瑞健高科生物科技有限公司 | 一种具有结构记忆特性的细胞生长支架 |
| US11484401B2 (en) | 2016-02-01 | 2022-11-01 | Medos International Sarl | Tissue augmentation scaffolds for use in soft tissue fixation repair |
| US20170273680A1 (en) | 2016-02-01 | 2017-09-28 | DePuy Synthes Products, Inc. | Tissue augmentation tacks for use with soft tissue fixation repair systems and methods |
| US11357495B2 (en) | 2016-02-01 | 2022-06-14 | Medos International Sarl | Tissue augmentation scaffolds for use with soft tissue fixation repair systems and methods |
| AU2017216900A1 (en) * | 2016-02-11 | 2018-08-09 | Lifecell Corporation | Methods for stabilizing collagen-containing tissue products against enzymatic degradation |
| US10792394B2 (en) | 2016-06-03 | 2020-10-06 | Lifecell Corporation | Methods for localized modification of tissue products |
| US10945831B2 (en) | 2016-06-03 | 2021-03-16 | Musculoskeletal Transplant Foundation | Asymmetric tissue graft |
| USD856517S1 (en) | 2016-06-03 | 2019-08-13 | Musculoskeletal Transplant Foundation | Asymmetric tissue graft |
| EP3777907A1 (fr) | 2016-07-05 | 2021-02-17 | LifeCell Corporation | Matrices tissulaires incorporant de plusieurs types de tissus |
| JP2018033694A (ja) * | 2016-08-31 | 2018-03-08 | 新幹工業株式会社 | 結合組織体の形成方法 |
| RU2749991C2 (ru) | 2016-08-31 | 2021-06-21 | Лайфселл Корпорейшн | Устройство для коррекции молочной железы |
| HUE055940T2 (hu) | 2016-09-12 | 2022-01-28 | Gebauer Klopotek Patent Verwaltungs Ug | Lencsék intrastromális szaruhártya-beültetéshez |
| EP3558405A1 (fr) | 2016-12-22 | 2019-10-30 | LifeCell Corporation | Dispositifs et procédés de cryobroyage de tissu |
| AU2018212910A1 (en) | 2017-01-30 | 2019-08-01 | Lifecell Corporation | Devices including muscle matrix and methods of production and use |
| EP3573674A1 (fr) | 2017-01-30 | 2019-12-04 | LifeCell Corporation | Produits traités à l'aide de transglutaminase |
| KR20180131721A (ko) * | 2017-05-31 | 2018-12-11 | 포항공과대학교 산학협력단 | 피부 조직의 탈세포화 방법, 인공 피부 제작 방법, 탈세포화된 피부 조직의 하이드로젤 제조 방법, 동결 건조한 탈세화된 피부 조직 및 바이오 잉크 |
| JP2019037303A (ja) * | 2017-08-22 | 2019-03-14 | 多木化学株式会社 | コラーゲン管状体 |
| US11123375B2 (en) | 2017-10-18 | 2021-09-21 | Lifecell Corporation | Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products |
| CN115252910A (zh) | 2017-10-18 | 2022-11-01 | 生命细胞公司 | 脂肪组织产品以及产生方法 |
| WO2019079672A1 (fr) | 2017-10-19 | 2019-04-25 | Lifecell Corporation | Produits de matrice tissulaire acellulaire fluides et procédés de production |
| US11246994B2 (en) | 2017-10-19 | 2022-02-15 | Lifecell Corporation | Methods for introduction of flowable acellular tissue matrix products into a hand |
| WO2019159182A1 (fr) | 2018-02-18 | 2019-08-22 | G & G Biotechnology Ltd. | Implants ayant une meilleure adhérence de coque |
| EP3787702B1 (fr) | 2018-05-03 | 2024-08-07 | CollPlant Ltd. | Produits de comblement cutanés et leurs applications |
| CN112292099A (zh) * | 2018-07-02 | 2021-01-29 | 盖鲍厄-克洛波泰克佩坦特弗瓦尔屯格斯-尤格公司 | 胶原蛋白支架的稳定 |
| US12350144B2 (en) | 2018-07-02 | 2025-07-08 | Gebauer-Klopotek Patent Verw Altungs-Ug | Stabilization of collagen scaffolds |
| US10813743B2 (en) | 2018-09-07 | 2020-10-27 | Musculoskeletal Transplant Foundation | Soft tissue repair grafts and processes for preparing and using same |
| USD895812S1 (en) | 2018-09-07 | 2020-09-08 | Musculoskeletal Transplant Foundation | Soft tissue repair graft |
| CN110354310A (zh) * | 2019-01-30 | 2019-10-22 | 张亚平 | 后巩膜加固术用生物补片及其制备方法 |
| CN110353856B (zh) * | 2019-01-30 | 2023-04-28 | 张亚平 | 一种眼后巩膜加固术用生物补片及其制备方法 |
| CN110353857A (zh) * | 2019-01-30 | 2019-10-22 | 张亚平 | 眼后巩膜加固术用生物补片及其制备方法 |
| US11298220B2 (en) | 2019-05-03 | 2022-04-12 | Lifecell Corporation | Breast treatment device |
| MX2021014654A (es) | 2019-05-30 | 2022-03-11 | Lifecell Corp | Implante de mama biologico. |
| US20230114297A1 (en) * | 2019-09-25 | 2023-04-13 | Allosource | Pre-shaped allograft implant for reconstructive surgical use and methods of manufacture and use, and tools for forming a pre-shaped allograft implant for reconstructive surgical use |
| AU2022340544A1 (en) * | 2021-08-30 | 2024-02-15 | Allosource | Pre-shaped allograft implant for reconstructive surgical use and methods of manufacture and use, and tools for forming a pre-shaped allograft implant for reconstructive surgical use |
| USD1101168S1 (en) | 2023-08-09 | 2025-11-04 | Allosource | Acellular dermal matrix sheet allograft |
| FR3158220A1 (fr) | 2024-01-16 | 2025-07-18 | Ph Tech | Dispositif médical destiné à recevoir un élément de remplissage |
| WO2026010511A1 (fr) * | 2024-07-05 | 2026-01-08 | Bekelaar Kiliana | Greffons implantables et procédés de production d'échafaudages collagènes |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1073243A (en) * | 1963-12-13 | 1967-06-21 | Ethicon Inc | Twisted collagen ribbon |
| DE2967060D1 (en) * | 1979-12-18 | 1984-07-19 | Oscobal Ag | Bone replacement material and process for producing a bone replacement material |
| GB8413319D0 (en) * | 1984-05-24 | 1984-06-27 | Oliver Roy Frederick | Biological material |
| US4865602A (en) * | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| US4978352A (en) * | 1989-06-07 | 1990-12-18 | Fedorov Svjatoslav N | Process for producing collagen-based cross-linked biopolymer, an implant from said biopolymer, method for producing said implant, and method for hermetization of corneal or scleral wounds involved in eye injuries, using said implant |
| US8067149B2 (en) | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
| CA2051092C (fr) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Methode et appareillage pour la cryopreservation, la stabilisation a sec et la rehydratation de suspensions biologiques |
| US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| JP3471967B2 (ja) | 1995-03-28 | 2003-12-02 | カネボウ株式会社 | ハイブリッド型人工歯根 |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| US6734018B2 (en) | 1999-06-07 | 2004-05-11 | Lifenet | Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced |
| FR2786400B1 (fr) * | 1998-11-30 | 2002-05-10 | Imedex Biomateriaux | Procede de preparation d'un materiau collagenique a vitesse de biodegradation in vivo controlee et materiaux obtenus |
| WO2003032735A1 (fr) | 2001-10-18 | 2003-04-24 | Lifecell Corporation | Remodelage de tissus et d'organes |
| US20030187515A1 (en) * | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| JPWO2003094985A1 (ja) * | 2002-05-14 | 2005-09-08 | 北海道ティー・エル・オー株式会社 | 人工細胞外マトリックス及びその製造方法 |
| US20030229394A1 (en) * | 2002-06-06 | 2003-12-11 | Ogle Matthew F. | Processed tissue for medical device formation |
| CA2533259C (fr) | 2003-07-21 | 2014-01-28 | Lifecell Corporation | Matrices de tissus acellulaires realisees a partir de tissus deficitaires en galactose .alpha.-1,3-galactose |
| GB0415080D0 (en) * | 2004-07-05 | 2004-08-04 | Ucl Biomedica Plc | Methods for preparing tissue equivalent implants and products thereof |
| US20060073592A1 (en) * | 2004-10-06 | 2006-04-06 | Wendell Sun | Methods of storing tissue matrices |
| JP5478884B2 (ja) | 2005-09-26 | 2014-04-23 | ライフセル コーポレーション | 乾燥血小板組成物 |
| US20070248575A1 (en) * | 2006-04-19 | 2007-10-25 | Jerome Connor | Bone graft composition |
| EP2015707B1 (fr) | 2006-05-09 | 2019-01-23 | LifeCell Corporation | Tissu biologique renforcé |
| TW200916069A (en) * | 2007-06-24 | 2009-04-16 | Gary Pierre Lauryssen | Human mammary prosthetic support |
| CZ301086B6 (cs) * | 2007-10-17 | 2009-11-04 | Bio-Skin, A. S. | Sterilní autologní, allogenní nebo xenogenní implantát a zpusob jeho výroby |
| CA2726350C (fr) | 2008-06-06 | 2016-07-19 | Lifecell Corporation | Traitement par elastase de matrices de tissu |
| CN103751842A (zh) * | 2008-07-30 | 2014-04-30 | 米辛瑟斯有限公司 | 衍生自前胃胞外基质的组织支架 |
| EP2349089A4 (fr) | 2008-11-21 | 2014-01-15 | Lifecell Corp | Matériau biologique renforcé |
| US8986377B2 (en) | 2009-07-21 | 2015-03-24 | Lifecell Corporation | Graft materials for surgical breast procedures |
-
2011
- 2011-07-07 AU AU2011276246A patent/AU2011276246B2/en not_active Ceased
- 2011-07-07 WO PCT/US2011/043129 patent/WO2012006390A1/fr not_active Ceased
- 2011-07-07 CN CN201180031832.4A patent/CN103068413B/zh not_active Expired - Fee Related
- 2011-07-07 CA CA3054722A patent/CA3054722A1/fr not_active Abandoned
- 2011-07-07 EP EP19189855.0A patent/EP3581211A1/fr not_active Withdrawn
- 2011-07-07 EP EP11738529.4A patent/EP2590691B1/fr active Active
- 2011-07-07 US US13/177,720 patent/US9636435B2/en not_active Expired - Fee Related
- 2011-07-07 CA CA2804592A patent/CA2804592C/fr not_active Expired - Fee Related
- 2011-07-07 JP JP2013518817A patent/JP5967721B2/ja not_active Expired - Fee Related
- 2011-07-07 ES ES11738529T patent/ES2759445T3/es active Active
-
2016
- 2016-12-14 US US15/378,447 patent/US20170100509A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011276246A1 (en) | 2013-01-10 |
| CA2804592A1 (fr) | 2012-01-12 |
| EP3581211A1 (fr) | 2019-12-18 |
| CA3054722A1 (fr) | 2012-01-12 |
| EP2590691A1 (fr) | 2013-05-15 |
| WO2012006390A1 (fr) | 2012-01-12 |
| CN103068413A (zh) | 2013-04-24 |
| ES2759445T3 (es) | 2020-05-11 |
| US20120010728A1 (en) | 2012-01-12 |
| JP2013535240A (ja) | 2013-09-12 |
| EP2590691B1 (fr) | 2019-09-04 |
| US20170100509A1 (en) | 2017-04-13 |
| CN103068413B (zh) | 2015-12-16 |
| JP5967721B2 (ja) | 2016-08-10 |
| US9636435B2 (en) | 2017-05-02 |
| AU2011276246B2 (en) | 2014-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2804592C (fr) | Procede de formation de matrices de tissu | |
| US20250195721A1 (en) | Natural tissue scaffolds as tissue fillers | |
| US20250288722A1 (en) | Method for enzymatic treatment of tissue products | |
| AU2012355463B2 (en) | Sheet tissue products | |
| ES2720137T3 (es) | Método para el tratamiento enzimático de productos tisular | |
| US20160030487A1 (en) | Methods for selection of age-appropriate tissues | |
| CA2854885A1 (fr) | Dispositif pour le traitement d'un tendon et d'un ligament | |
| EP3549616B1 (fr) | Procédés de traitement enzymatique de produits tissulaires | |
| HK40018681A (en) | Method for shaping tissue matrices | |
| HK40016155A (en) | Method for enzymatic treatment of tissue products | |
| HK40016155B (en) | Method for enzymatic treatment of tissue products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160608 |
|
| MKLA | Lapsed |
Effective date: 20220707 |