CA2807859A1 - Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate - Google Patents

Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate Download PDF

Info

Publication number
CA2807859A1
CA2807859A1 CA2807859A CA2807859A CA2807859A1 CA 2807859 A1 CA2807859 A1 CA 2807859A1 CA 2807859 A CA2807859 A CA 2807859A CA 2807859 A CA2807859 A CA 2807859A CA 2807859 A1 CA2807859 A1 CA 2807859A1
Authority
CA
Canada
Prior art keywords
compound
formula
solvate
methyl
modification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2807859A
Other languages
English (en)
Inventor
Birgit Keil
Franz-Josef Mais
Winfried Joentgen
Alfons Grunenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adverio Pharma GmbH
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Priority to CA2807859A priority Critical patent/CA2807859A1/fr
Priority to AU2014220801A priority patent/AU2014220801A1/en
Priority to MX2015010725A priority patent/MX2015010725A/es
Priority to HK16105474.6A priority patent/HK1217488A1/zh
Priority to KR1020157022555A priority patent/KR20150119871A/ko
Priority to AP2015008670A priority patent/AP2015008670A0/xx
Priority to PE2015001788A priority patent/PE20151590A1/es
Priority to PCT/EP2014/053096 priority patent/WO2014128109A1/fr
Priority to CA2901636A priority patent/CA2901636A1/fr
Priority to EA201500852A priority patent/EA201500852A1/ru
Priority to US14/769,334 priority patent/US20150376184A1/en
Priority to SG11201506211RA priority patent/SG11201506211RA/en
Priority to CN201480009667.6A priority patent/CN105102457A/zh
Priority to EP14705337.5A priority patent/EP2958914B1/fr
Priority to JP2015558419A priority patent/JP6386478B2/ja
Priority to BR112015019571A priority patent/BR112015019571A2/pt
Priority to EP20185169.8A priority patent/EP3760629A1/fr
Publication of CA2807859A1 publication Critical patent/CA2807859A1/fr
Priority to IL240397A priority patent/IL240397A0/en
Priority to CL2015002304A priority patent/CL2015002304A1/es
Priority to NI201500110A priority patent/NI201500110A/es
Priority to DO2015000199A priority patent/DOP2015000199A/es
Priority to CR20150422A priority patent/CR20150422A/es
Priority to PH12015501839A priority patent/PH12015501839A1/en
Priority to CUP2015000092A priority patent/CU20150092A7/es
Priority to TN2015000361A priority patent/TN2015000361A1/en
Priority to US15/672,921 priority patent/US10087183B2/en
Priority to US16/119,671 priority patent/US10662188B2/en
Priority to US16/848,249 priority patent/US11203593B2/en
Priority to US17/526,129 priority patent/US12503469B2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2807859A 2013-02-21 2013-02-21 Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate Pending CA2807859A1 (fr)

Priority Applications (29)

Application Number Priority Date Filing Date Title
CA2807859A CA2807859A1 (fr) 2013-02-21 2013-02-21 Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate
EP20185169.8A EP3760629A1 (fr) 2013-02-21 2014-02-18 Formes du {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}méthylcarbamate de méthyle
BR112015019571A BR112015019571A2 (pt) 2013-02-21 2014-02-18 formas de {4,6-diamino-2-[1-(2-fluorobenzil)-1h-pirazolo[3,4-b]piridino-3-il]pirimidino-5-il}metilcarbamato de metila
HK16105474.6A HK1217488A1 (zh) 2013-02-21 2014-02-18 {4,6-二氨基-2-[1-(2-氟苄基)-1h-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸甲酯的形式
KR1020157022555A KR20150119871A (ko) 2013-02-21 2014-02-18 메틸 ｛4,6-디아미노-2-[1-(2-플루오로벤질)-1H-피라졸로[3,4-b]피리디노-3-일]피리미디노-5-일｝메틸 카르바메이트의 형태
AP2015008670A AP2015008670A0 (en) 2013-02-21 2014-02-18 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-B]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate
PE2015001788A PE20151590A1 (es) 2013-02-21 2014-02-18 Formas del metil {4,6-diamino-2- [1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato
PCT/EP2014/053096 WO2014128109A1 (fr) 2013-02-21 2014-02-18 Formes du {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}méthylcarbamate de méthyle
CA2901636A CA2901636A1 (fr) 2013-02-21 2014-02-18 Formes du {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate de methyle
EA201500852A EA201500852A1 (ru) 2013-02-21 2014-02-18 Формы метил {4,6-диамино-2-[1-(2-фторбензил)-1н-пиразоло[3,4-в]пиридино-3-ил]пиримидино-5-ил}метил карбамата
MX2015010725A MX2015010725A (es) 2013-02-21 2014-02-18 Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.
SG11201506211RA SG11201506211RA (en) 2013-02-21 2014-02-18 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
CN201480009667.6A CN105102457A (zh) 2013-02-21 2014-02-18 {4,6-二氨基-2-[1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸甲酯的形式
EP14705337.5A EP2958914B1 (fr) 2013-02-21 2014-02-18 Formes du {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}méthylcarbamate de méthyle
JP2015558419A JP6386478B2 (ja) 2013-02-21 2014-02-18 メチル｛４，６−ジアミノ−２−［１−（２−フルオロベンジル）−１ｈ−ピラゾロ［３，４−ｂ］ピリジノ−３−イル］ピリミジノ−５−イル｝メチルカルバメートの形態
AU2014220801A AU2014220801A1 (en) 2013-02-21 2014-02-18 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
US14/769,334 US20150376184A1 (en) 2013-02-21 2014-02-18 Forms of methyl methyl carbamate
IL240397A IL240397A0 (en) 2013-02-21 2015-08-06 Forms of methyl {6,4-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo [[b-4,3-pyridino-3-yl]pyrimidino-5-yl} methyl carbamate
NI201500110A NI201500110A (es) 2013-02-21 2015-08-17 FORMAS DEL METIL {4,6-DIAMINO-2-[1-(2-FLUOROBENCIL)-1h-PIRAZOLO [4,3-B] PIRIDINO-3-IL]PIRIMIDINO-5-IL} METIL CARBAMATO
CL2015002304A CL2015002304A1 (es) 2013-02-21 2015-08-17 Formas del metil {4,6-diamino-2- [1- (2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato
DO2015000199A DOP2015000199A (es) 2013-02-21 2015-08-18 Formas del metil {4,6-diamino-2- [1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato
CR20150422A CR20150422A (es) 2013-02-21 2015-08-18 Formas de metilo {4,6-diamino-2-[1- (2-fluorobencil) -1h-pirazolo [3,4-b] piridino -3-il] pirimidino-5-il} carbamato de metilo
PH12015501839A PH12015501839A1 (en) 2013-02-21 2015-08-20 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
CUP2015000092A CU20150092A7 (es) 2013-02-21 2015-08-20 Formas del metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato
TN2015000361A TN2015000361A1 (en) 2013-02-21 2015-08-21 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
US15/672,921 US10087183B2 (en) 2013-02-21 2017-08-09 Forms of methyl {4,6-diamino-2-[1 (2-fluorobenzyl)-1h-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
US16/119,671 US10662188B2 (en) 2013-02-21 2018-08-31 Forms of methyl {4,6-diamino-2-[1 (2-fluorobenzyl)-1H-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate
US16/848,249 US11203593B2 (en) 2013-02-21 2020-04-14 Forms of methyl {4,6-diamino-2-[1(2-fluorobenzyl)-1H-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate
US17/526,129 US12503469B2 (en) 2013-02-21 2021-11-15 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2807859A CA2807859A1 (fr) 2013-02-21 2013-02-21 Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate

Publications (1)

Publication Number Publication Date
CA2807859A1 true CA2807859A1 (fr) 2014-08-21

Family

ID=51386052

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2807859A Pending CA2807859A1 (fr) 2013-02-21 2013-02-21 Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate

Country Status (1)

Country Link
CA (1) CA2807859A1 (fr)

Similar Documents

Publication Publication Date Title
JP6514398B2 (ja) メチル｛４，６−ジアミノ−２−［１−（２−フルオロベンジル）−１Ｈ−ピラゾロ［３，４−ｂ］ピリジン−３−イル］ピリミジン−５−イル｝メチルカルバメートの調製方法および医薬上活性な化合物として用いるためのその精製方法
US7256195B2 (en) Preparation of risperidone
JP2008509953A (ja) ４−［［（７ｒ）−８−シクロペンチル−７−エチル−５，６，７，８−テトラヒドロ−５−メチル−４−６−オキソ−２−ピペリジニル］アミノ］−３−メトキシ−ｎ−（１−メチル−４−ピペリジニル）ベンズアミドの水和物及び多形、その製造方法、並びにその薬物としての使用
TWI706951B (zh) 一種週期素依賴性蛋白激酶抑制劑的羥乙基磺酸鹽、其結晶形式及製備方法
JP2022521537A (ja) イミダゾピリジニル化合物及び増殖性障害の処置のためのその使用
JP7836263B2 (ja) トリアジン化合物の塩、その結晶形及び製造方法
JP6752283B2 (ja) Ｅｇｆｒキナーゼ阻害剤およびその製造方法と使用
JP2019523273A (ja) ベリノスタットの多形形態、およびその調製のためのプロセス
JP6632127B2 (ja) トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物およびその中間体の製造方法
WO2009016653A1 (fr) Forme polymorphe stable de palipéridone et son procédé de préparation
KR20130025857A (ko) 2-［［［2-［(히드록시아세틸)아미노］-4-피리디닐］메틸］티오］-ｎ-［4-(트리플루오로메톡시)페닐］-3-피리딘카르복사미드의 벤젠술폰산염, 이의 결정, 이의 결정 다형 및 이들의 제조 방법
ES2699884T3 (es) Nuevo compuesto cristalino de arilalquilamina y método para producir el mismo
WO2002012200A1 (fr) Preparation de risperidone
CN102952138A (zh) 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用
CA2807859A1 (fr) Formes de methyle {4,6-diamino-2-[1-(2-fluorobenzyle)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyri midino-5-yl}methyle carbamate
CN113896727B (zh) 异白叶藤碱类似物、从加替沙星到异白叶藤碱类似物的制备方法和应用
EP3604284A1 (fr) Forme cristalline d du sel de monoéthanolamine d'eltrombopag
CN114276369B (zh) 异白叶藤碱类似物、从芦氟沙星到异白叶藤碱类似物的制备方法和应用
CN113912603B (zh) 异白叶藤碱类似物、从环丙沙星到异白叶藤碱类似物的制备方法和应用
EP2705034A1 (fr) Sel de sodium cristallin d'un inhibiteur d'intégrase du vih
JP6985137B2 (ja) スルホンアミド化合物の結晶形
WO2026092276A1 (fr) Composé pour inhiber la protéine ptpn et son utilisation
HK40116388A (zh) 用作cdk7激酶抑制剂的化合物及其应用
HK40061853B (zh) 用作cdk7激酶抑制剂的化合物及其应用
HK40058867A (en) Imidazopyridinyl compounds and use thereof for treatment of proliferative disorders

Legal Events

Date Code Title Description
MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250121

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250121

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250121

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260423