CA2826113C - C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity - Google Patents

C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity Download PDF

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Publication number
CA2826113C
CA2826113C CA2826113A CA2826113A CA2826113C CA 2826113 C CA2826113 C CA 2826113C CA 2826113 A CA2826113 A CA 2826113A CA 2826113 A CA2826113 A CA 2826113A CA 2826113 C CA2826113 C CA 2826113C
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CA
Canada
Prior art keywords
alkyl
compound
cyclopenta
octadecahydro
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
CA2826113A
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English (en)
French (fr)
Other versions
CA2826113A1 (en
Inventor
Alicia Regueiro-Ren
Zheng Liu
Jacob Swidorski
Ny Sin
Brian Lee Venables
Sing-Yuen Sit
Yan Chen
Jie Chen
Nicholas A. Meanwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViiV Healthcare UK No 4 Ltd
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ViiV Healthcare UK No 4 Ltd
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Publication of CA2826113A1 publication Critical patent/CA2826113A1/en
Application granted granted Critical
Publication of CA2826113C publication Critical patent/CA2826113C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2826113A 2011-01-31 2012-01-27 C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity Active CA2826113C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437893P 2011-01-31 2011-01-31
US61/437,893 2011-01-31
PCT/US2012/022852 WO2012106190A1 (en) 2011-01-31 2012-01-27 C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity

Publications (2)

Publication Number Publication Date
CA2826113A1 CA2826113A1 (en) 2012-08-09
CA2826113C true CA2826113C (en) 2018-09-04

Family

ID=45567147

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2826113A Active CA2826113C (en) 2011-01-31 2012-01-27 C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity

Country Status (25)

Country Link
US (3) US8846647B2 (2)
EP (1) EP2670765B1 (2)
JP (1) JP6001560B2 (2)
KR (1) KR101886467B1 (2)
CN (1) CN103429607B (2)
AR (1) AR085053A1 (2)
AU (1) AU2012212509B2 (2)
BR (1) BR112013019419A2 (2)
CA (1) CA2826113C (2)
CL (1) CL2013002185A1 (2)
CO (1) CO6751275A2 (2)
EA (1) EA022470B1 (2)
ES (1) ES2653847T3 (2)
IL (1) IL227678B (2)
MA (1) MA34909B1 (2)
MY (1) MY162186A (2)
PE (1) PE20141152A1 (2)
PH (1) PH12013501528A1 (2)
PT (1) PT2670765T (2)
SG (1) SG192144A1 (2)
TN (1) TN2013000321A1 (2)
TW (1) TWI628188B (2)
UY (1) UY33886A (2)
WO (1) WO2012106190A1 (2)
ZA (1) ZA201306546B (2)

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KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
MX2010011439A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17.
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CN103596929B (zh) 2010-12-17 2016-10-19 里亚塔医药公司 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮
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US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
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KR20150121712A (ko) * 2013-02-25 2015-10-29 브리스톨-마이어스 스큅 컴퍼니 Hiv의 치료에 유용한 c-3 알킬 및 알케닐 개질된 베툴린산 유도체
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US20180194799A1 (en) 2015-07-28 2018-07-12 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
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JP7074674B2 (ja) 2015-09-23 2022-05-24 リアタ ファーマシューティカルズ インコーポレイテッド Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体
KR20180054826A (ko) 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 성숙 억제 활성을 갖는 화합물
EP3377177A2 (en) 2015-11-20 2018-09-26 VIIV Healthcare UK(No.4) Limited Hiv maturation inhibitor formulations
EP3405474A1 (en) * 2016-01-20 2018-11-28 Glaxosmithkline Intellectual Property (No. 2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
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JP6977474B2 (ja) * 2017-10-23 2021-12-08 東京エレクトロン株式会社 半導体装置の製造方法
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Also Published As

Publication number Publication date
IL227678A0 (en) 2013-09-30
EP2670765B1 (en) 2017-10-18
MA34909B1 (fr) 2014-02-01
JP2014503595A (ja) 2014-02-13
US20140343000A1 (en) 2014-11-20
PE20141152A1 (es) 2014-09-22
IL227678B (en) 2018-04-30
ES2653847T3 (es) 2018-02-09
AR085053A1 (es) 2013-08-07
US20160151387A1 (en) 2016-06-02
WO2012106190A1 (en) 2012-08-09
ZA201306546B (en) 2015-03-25
EP2670765A1 (en) 2013-12-11
AU2012212509B2 (en) 2016-01-21
CO6751275A2 (es) 2013-09-16
CN103429607B (zh) 2016-02-17
CN103429607A (zh) 2013-12-04
MY162186A (en) 2017-05-31
BR112013019419A2 (pt) 2019-12-03
US8846647B2 (en) 2014-09-30
SG192144A1 (en) 2013-08-30
PH12013501528A1 (en) 2013-09-16
CL2013002185A1 (es) 2013-12-27
TN2013000321A1 (en) 2015-01-20
TW201309717A (zh) 2013-03-01
UY33886A (es) 2012-07-31
KR20140016279A (ko) 2014-02-07
TWI628188B (zh) 2018-07-01
JP6001560B2 (ja) 2016-10-05
NZ614871A (en) 2014-06-27
KR101886467B1 (ko) 2018-08-07
AU2012212509A1 (en) 2013-09-19
PT2670765T (pt) 2018-01-08
US20130035318A1 (en) 2013-02-07
EA201391127A1 (ru) 2013-12-30
CA2826113A1 (en) 2012-08-09
EA022470B1 (ru) 2016-01-29

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