CA2867766C - Membrane d'espacement ameliore pour un capteur enzymatique in vivo - Google Patents

Membrane d'espacement ameliore pour un capteur enzymatique in vivo Download PDF

Info

Publication number
CA2867766C
CA2867766C CA2867766A CA2867766A CA2867766C CA 2867766 C CA2867766 C CA 2867766C CA 2867766 A CA2867766 A CA 2867766A CA 2867766 A CA2867766 A CA 2867766A CA 2867766 C CA2867766 C CA 2867766C
Authority
CA
Canada
Prior art keywords
electrode system
hydrophilic
copolymer
methacrylate
acrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2867766A
Other languages
English (en)
Other versions
CA2867766A1 (fr
Inventor
Arnulf Staib
Marcel Thiele
Karl-Heinz Koelker
Ewald Rieger
Alexander Licht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/055406 external-priority patent/WO2012130841A1/fr
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2867766A1 publication Critical patent/CA2867766A1/fr
Application granted granted Critical
Publication of CA2867766C publication Critical patent/CA2867766C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

La présente invention concerne un système d'électrodes pour mesurer la concentration d'un analyte en conditions in vivo, comprenant une électrode avec des molécules d'enzyme immobilisées et une barrière de diffusion améliorée qui régule la diffusion de l'analyte du fluide corporel entourant le système d'électrode aux molécules enzymatiques.
CA2867766A 2012-03-27 2013-03-27 Membrane d'espacement ameliore pour un capteur enzymatique in vivo Active CA2867766C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2012/055406 2012-03-27
PCT/EP2012/055406 WO2012130841A1 (fr) 2011-03-28 2012-03-27 Couche de diffusion améliorée pour un capteur enzymatique in vivo
PCT/EP2013/056619 WO2013144255A1 (fr) 2012-03-27 2013-03-27 Membrane d'espacement amélioré pour un capteur enzymatique in vivo

Publications (2)

Publication Number Publication Date
CA2867766A1 CA2867766A1 (fr) 2013-10-03
CA2867766C true CA2867766C (fr) 2018-08-07

Family

ID=48014011

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867766A Active CA2867766C (fr) 2012-03-27 2013-03-27 Membrane d'espacement ameliore pour un capteur enzymatique in vivo

Country Status (5)

Country Link
JP (1) JP6374860B2 (fr)
CN (2) CN106957887A (fr)
CA (1) CA2867766C (fr)
RU (1) RU2611038C2 (fr)
WO (1) WO2013144255A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11073495B2 (en) 2015-10-15 2021-07-27 Arkray, Inc. Biosensor and manufacturing method of biosensor
US10228341B2 (en) 2015-10-15 2019-03-12 Arkray, Inc. Biosensor
SMT202400475T1 (it) 2016-02-05 2025-01-14 Hoffmann La Roche Dispositivo medico per rilevare almeno un analita in un fluido corporeo
HRP20241251T1 (hr) 2016-02-05 2024-12-06 F. Hoffmann - La Roche Ag Medicinski uređaj za otkrivanje najmanje jednog analita u tjelesnoj tekućini
CN110023502A (zh) * 2016-12-08 2019-07-16 豪夫迈·罗氏有限公司 用于在体内条件下测定分析物浓度的传感器装置和制造方法
GB2559627A (en) * 2017-02-14 2018-08-15 Ndm Tech Ltd Device
WO2019006413A1 (fr) * 2017-06-30 2019-01-03 Abbott Diabetes Care Procédé et appareil de détection d'analyte à l'aide d'un biocapteur électrochimique
ES3023573T3 (en) * 2017-09-18 2025-06-02 Hoffmann La Roche Electrochemical sensor for detecting at least one analyte
SMT202500057T1 (it) 2017-12-21 2025-03-12 Hoffmann La Roche Sistema medico e procedimento di fabbricazione dello stesso
WO2019146788A1 (fr) 2018-01-29 2019-08-01 Ｐｈｃホールディングス株式会社 Matériau de film protecteur pour sonde de biocapteur
JPWO2019176339A1 (ja) 2018-03-13 2021-03-18 Ｐｈｃホールディングス株式会社 バイオセンサプローブ用保護膜材料
ES2924910T3 (es) * 2018-05-04 2022-10-11 Hoffmann La Roche Capa de difusión mejorada para un sensor enzimático in vivo
CN108931568B (zh) * 2018-05-25 2020-09-01 南京佳乐净膜科技有限公司 生物传感器及其制备方法
JP7293339B2 (ja) * 2018-08-23 2023-06-19 アボット ダイアベティス ケア インコーポレイテッド 配向された鍼灸針を含むニードルアセンブリ及びその製造方法
JP7161610B2 (ja) * 2018-09-27 2022-10-26 アイセンス，インコーポレーテッド 血中グルコースの流入を調節する重合体ブレンド、これを含む持続血糖測定用バイオセンサ
CA3070332A1 (fr) * 2019-04-30 2020-10-30 Microtech Medical (Hangzhou) Co., Ltd. Biocapteurs revetus de copolymeres, et leur utilisation
ES1289104Y (es) * 2019-04-30 2022-06-28 Microtech Medical Hangzhou Co Ltd Sistemas de biodeteccion con biosensores recubiertos de copolimeros y sus usos.
KR102389269B1 (ko) * 2022-02-16 2022-04-21 네메시스 주식회사 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서
CN116698945A (zh) 2023-06-09 2023-09-05 深圳津合生物有限公司 一种酶电极系统及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6793789B2 (en) * 2000-09-30 2004-09-21 Geun Sig Cha Reference electrode with a polymeric reference electrode membrane
US7226978B2 (en) * 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
JP4791349B2 (ja) * 2003-02-28 2011-10-12 バイオインターラクションズ リミテッド 医療機器のためのポリマーネットワークシステム及び使用方法
US7109271B2 (en) * 2004-07-28 2006-09-19 Lifescan, Inc. Redox polymers for use in electrochemical-based sensors
US20060121547A1 (en) 2004-12-03 2006-06-08 Mcintire Mark Diffusion layer for an enzyme-based sensor application
US7959791B2 (en) * 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
US20060275859A1 (en) * 2005-05-17 2006-12-07 Kjaer Thomas Enzyme sensor including a water-containing spacer layer
CA2654220A1 (fr) 2006-06-19 2007-12-27 F. Hoffmann-La Roche Ag Capteur amperometrique et son procede de fabrication
CA2680213C (fr) * 2007-03-07 2014-10-14 Echo Therapeutics, Inc. Systemes et procedes de controle d'analyte transdermique pour une detection d'analyte
EP2163190A1 (fr) * 2008-09-11 2010-03-17 Roche Diagnostics GmbH Système d'électrodes pour la mesure d'une concentration d'analyte in vivo
US9322103B2 (en) * 2010-08-06 2016-04-26 Microchips Biotech, Inc. Biosensor membrane composition, biosensor, and methods for making same

Also Published As

Publication number Publication date
CN104334740B (zh) 2017-05-24
WO2013144255A1 (fr) 2013-10-03
RU2014142913A (ru) 2016-05-20
CN106957887A (zh) 2017-07-18
RU2611038C2 (ru) 2017-02-20
CN104334740A (zh) 2015-02-04
JP2015515305A (ja) 2015-05-28
JP6374860B2 (ja) 2018-08-15
CA2867766A1 (fr) 2013-10-03

Similar Documents

Publication Publication Date Title
US20230258595A1 (en) Diffusion barriers and spacer membranes for enzymatic in-vivo sensors
CA2867766C (fr) Membrane d'espacement ameliore pour un capteur enzymatique in vivo
CN101473225B (zh) 电流型传感器及其制造方法
US20260069172A1 (en) Diffusion layer for an enzymatic in-vivo sensor
EP2831263B1 (fr) Membrane d'espacement amélioré pour un capteur enzymatique in vivo
HK1235835A1 (en) Improved spacer membrane for an enzymatic in-vivo sensor
HK1206793B (en) Improved spacer membrane for an enzymatic in-vivo sensor
HK1191984B (en) Improved diffusion layer for an enzymatic in-vivo sensor
HK40043207A (en) Improved diffusion layer for an enzymatic in-vivo sensor

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140918

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250227

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250227