JP6374860B2 - インビボ酵素センサー用の改良されたスペーサーメンブレン - Google Patents

インビボ酵素センサー用の改良されたスペーサーメンブレン Download PDF

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JP6374860B2
JP6374860B2 JP2015502344A JP2015502344A JP6374860B2 JP 6374860 B2 JP6374860 B2 JP 6374860B2 JP 2015502344 A JP2015502344 A JP 2015502344A JP 2015502344 A JP2015502344 A JP 2015502344A JP 6374860 B2 JP6374860 B2 JP 6374860B2
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electrode system
hydrophilic
copolymer
methacrylate
electrode
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JP2015515305A (ja
Inventor
シュタイプ、アルヌルフ
ティーレ、マルセル
ケルカー、カール−ハインツ
リーガー、エヴァルト
リヒト、アレクサンダー
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エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
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Priority claimed from PCT/EP2012/055406 external-priority patent/WO2012130841A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2015502344A 2012-03-27 2013-03-27 インビボ酵素センサー用の改良されたスペーサーメンブレン Active JP6374860B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2012/055406 WO2012130841A1 (fr) 2011-03-28 2012-03-27 Couche de diffusion améliorée pour un capteur enzymatique in vivo
EPPCT/EP2012/055406 2012-03-27
PCT/EP2013/056619 WO2013144255A1 (fr) 2012-03-27 2013-03-27 Membrane d'espacement amélioré pour un capteur enzymatique in vivo

Publications (2)

Publication Number Publication Date
JP2015515305A JP2015515305A (ja) 2015-05-28
JP6374860B2 true JP6374860B2 (ja) 2018-08-15

Family

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JP2015502344A Active JP6374860B2 (ja) 2012-03-27 2013-03-27 インビボ酵素センサー用の改良されたスペーサーメンブレン

Country Status (5)

Country Link
JP (1) JP6374860B2 (fr)
CN (2) CN104334740B (fr)
CA (1) CA2867766C (fr)
RU (1) RU2611038C2 (fr)
WO (1) WO2013144255A1 (fr)

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US11073495B2 (en) 2015-10-15 2021-07-27 Arkray, Inc. Biosensor and manufacturing method of biosensor
EP3156789B1 (fr) 2015-10-15 2024-01-03 ARKRAY, Inc. Biocapteur
SI3909506T1 (sl) 2016-02-05 2023-09-29 F. Hoffmann - La Roche Ag Medicinski pripomoček za odkrivanje vsaj enega analita v telesni tekočini
RS66283B1 (sr) 2016-02-05 2025-01-31 Hoffmann La Roche Medicinski uređaj za detekciju najmanje jednog analita u telesnoj tečnosti
CN110023502A (zh) * 2016-12-08 2019-07-16 豪夫迈·罗氏有限公司 用于在体内条件下测定分析物浓度的传感器装置和制造方法
GB2559627A (en) * 2017-02-14 2018-08-15 Ndm Tech Ltd Device
CA3065339A1 (fr) * 2017-06-30 2019-01-03 Abbott Diabetes Care Inc. Procede et appareil de detection d'analyte a l'aide d'un biocapteur electrochimique
EP3457121B1 (fr) * 2017-09-18 2025-03-12 Roche Diabetes Care GmbH Capteur électrochimique pour détecter au moins un analyte
DE202018006862U1 (de) * 2017-12-21 2023-11-16 Roche Diabetes Care Gmbh Medizinisches System
CN111655147A (zh) 2018-01-29 2020-09-11 普和希控股公司 生物传感器探针用保护膜材料
CN111867469A (zh) 2018-03-13 2020-10-30 普和希控股公司 生物传感器探针用保护膜材料
CA3092192C (fr) 2018-05-04 2023-11-21 F. Hoffmann-La Roche Ag Couche de diffusion amelioree pour un capteur enzymatique in vivo
CN108931568B (zh) * 2018-05-25 2020-09-01 南京佳乐净膜科技有限公司 生物传感器及其制备方法
JP7293339B2 (ja) * 2018-08-23 2023-06-19 アボット ダイアベティス ケア インコーポレイテッド 配向された鍼灸針を含むニードルアセンブリ及びその製造方法
EP3858913A4 (fr) * 2018-09-27 2022-06-15 i-Sens, Inc. Mélange de polymères pour réguler l'afflux de glycémie, et biocapteur de surveillance continue du glucose comprenant celui-ci
JP2021525356A (ja) * 2019-04-30 2021-09-24 微泰医療器械（杭州）有限公司Ｍｉｃｒｏ Ｔｅｃｈ Ｍｅｄｉｃａｌ （Ｈａｎｇｚｈｏｕ） Ｃｏ．，Ｌｔｄ． 共重合体でコーティングされたバイオセンサーを有するバイオセンサシステムおよびその使用
WO2020220261A1 (fr) * 2019-04-30 2020-11-05 Micro Tech Medical (Hangzhou) Co., Ltd. Biocapteurs revêtus de co-polymères et leurs utilisations
KR102389269B1 (ko) * 2022-02-16 2022-04-21 네메시스 주식회사 연속혈당측정 바이오센서용 글루코즈 확산 제어막 용액, 이를 포함하는 연속혈당측정 바이오센서용 글루코즈 확산 제어막 및 이를 포함하는 연속혈당측정용 바이오센서
CN116698945A (zh) 2023-06-09 2023-09-05 深圳津合生物有限公司 一种酶电极系统及其应用

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US6793789B2 (en) * 2000-09-30 2004-09-21 Geun Sig Cha Reference electrode with a polymeric reference electrode membrane
US7226978B2 (en) * 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
PL1603603T3 (pl) * 2003-02-28 2015-07-31 Biointeractions Ltd System sieci polimerowych dla urządzeń medycznych oraz sposoby zastosowania
US7109271B2 (en) * 2004-07-28 2006-09-19 Lifescan, Inc. Redox polymers for use in electrochemical-based sensors
US20060121547A1 (en) 2004-12-03 2006-06-08 Mcintire Mark Diffusion layer for an enzyme-based sensor application
US20060275859A1 (en) * 2005-05-17 2006-12-07 Kjaer Thomas Enzyme sensor including a water-containing spacer layer
US7959791B2 (en) * 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
WO2007147475A1 (fr) 2006-06-19 2007-12-27 Roche Diagnostics Gmbh Capteur ampérométrique et son procédé de fabrication
US8812071B2 (en) * 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
EP2163190A1 (fr) * 2008-09-11 2010-03-17 Roche Diagnostics GmbH Système d'électrodes pour la mesure d'une concentration d'analyte in vivo
US9322103B2 (en) * 2010-08-06 2016-04-26 Microchips Biotech, Inc. Biosensor membrane composition, biosensor, and methods for making same

Also Published As

Publication number Publication date
JP2015515305A (ja) 2015-05-28
CA2867766C (fr) 2018-08-07
CA2867766A1 (fr) 2013-10-03
RU2014142913A (ru) 2016-05-20
CN104334740B (zh) 2017-05-24
CN104334740A (zh) 2015-02-04
CN106957887A (zh) 2017-07-18
WO2013144255A1 (fr) 2013-10-03
RU2611038C2 (ru) 2017-02-20

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