CA2868506C - Microparicules de cellules souches - Google Patents

Microparicules de cellules souches Download PDF

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Publication number
CA2868506C
CA2868506C CA2868506A CA2868506A CA2868506C CA 2868506 C CA2868506 C CA 2868506C CA 2868506 A CA2868506 A CA 2868506A CA 2868506 A CA2868506 A CA 2868506A CA 2868506 C CA2868506 C CA 2868506C
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hsa
mir
stem cell
neural stem
microparticles
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CA2868506A
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CA2868506A1 (fr
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John Sinden
Lara Stevanato
Randolph Corteling
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Reneuron Ltd
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Reneuron Ltd
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Priority claimed from GBGB1205972.1A external-priority patent/GB201205972D0/en
Priority claimed from GBGB1212848.4A external-priority patent/GB201212848D0/en
Priority claimed from GBGB1302468.2A external-priority patent/GB201302468D0/en
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Publication of CA2868506A1 publication Critical patent/CA2868506A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/088—Coculture with; Conditioned medium produced by cells of the nervous system neural stem cells

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  • Cardiology (AREA)
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Abstract

Cette invention se rapporte à des microparticules de cellules souches, leur utilisation et production, en particulier des microparticules de cellules souches neurales et leur utilisation en thérapie. La microparticule de cellules souches est typiquement un exosome ou microvésicule et peut être dérivée à partir d'une lignée de cellules souches neurales. La lignée de cellules souches neurales peut être une lignée de cellules souches à immortalisation conditionnelle telle que CTX0E03 (déposée auprès de l'ECACC avec le No d' Accès 04091601).
CA2868506A 2012-04-03 2013-04-03 Microparicules de cellules souches Active CA2868506C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1205972.1 2012-04-03
GBGB1205972.1A GB201205972D0 (en) 2012-04-03 2012-04-03 Stem cell product
GBGB1212848.4A GB201212848D0 (en) 2012-07-19 2012-07-19 Stem cell product
GB1212848.4 2012-07-19
GB1302468.2 2013-02-12
GBGB1302468.2A GB201302468D0 (en) 2013-02-12 2013-02-12 Stem cell product
PCT/GB2013/050879 WO2013150303A1 (fr) 2012-04-03 2013-04-03 Microparicules de cellules souches

Publications (2)

Publication Number Publication Date
CA2868506A1 CA2868506A1 (fr) 2013-10-10
CA2868506C true CA2868506C (fr) 2023-10-24

Family

ID=48095915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2868506A Active CA2868506C (fr) 2012-04-03 2013-04-03 Microparicules de cellules souches

Country Status (11)

Country Link
US (2) US20150079046A1 (fr)
EP (2) EP3470073A1 (fr)
JP (5) JP6450673B2 (fr)
KR (1) KR101993027B1 (fr)
CN (1) CN104321062B (fr)
AU (1) AU2013245406B2 (fr)
BR (1) BR112014024541A2 (fr)
CA (1) CA2868506C (fr)
ES (1) ES2691296T3 (fr)
SG (1) SG11201406336YA (fr)
WO (1) WO2013150303A1 (fr)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2829586C (fr) 2011-03-11 2021-03-02 Children's Medical Center Corporation Procedes et compositions associes aux exosomes de cellules souches mesenchymateuses
CA2879322A1 (fr) * 2012-07-19 2014-01-23 Reneuron Limited Microparticules de cellules souches
UA118548C2 (uk) 2012-12-21 2019-02-11 Епізайм, Інк. Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування
ES2927175T3 (es) * 2013-02-12 2022-11-03 Reneuron Ltd Método de producción de micropartículas
WO2014152906A2 (fr) 2013-03-14 2014-09-25 Research Institute At Nationwide Children's Hospital, Inc. Intestin issu de l'ingénierie tissulaire
WO2014197421A1 (fr) 2013-06-05 2014-12-11 Biotime, Inc. Compositions et procédés pour la régénération de tissus induite chez des espèces mammaliennes
EP3033418B1 (fr) * 2013-08-14 2019-12-11 Reneuron Limited Microparticules de cellules souches et miarn
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
EP3074050B1 (fr) * 2013-10-28 2020-09-09 Icahn School of Medicine at Mount Sinai Compositions et procédés pour moduler l'excitabilité neuronale et le comportement moteur
CN103740645A (zh) * 2013-12-06 2014-04-23 山西医科大学 神经干细胞来源Exosomes制备及在神经系统疾病中的应用
KR101662405B1 (ko) * 2013-12-12 2016-10-05 사회복지법인 삼성생명공익재단 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US20170173113A1 (en) * 2014-03-13 2017-06-22 Research Institute At Nationwide Children's Hospital Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
US9919011B2 (en) 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
CN103940998B (zh) * 2014-05-04 2016-04-20 山东大学 血清microRNA作为肝细胞癌转移的早期诊断标志物的应用
CA2949083C (fr) 2014-05-18 2023-10-10 Children's Medical Center Corporation Procedes et compositions apparentes a des exosomes
KR101593797B1 (ko) * 2014-05-22 2016-02-12 가톨릭대학교 산학협력단 ｍｉＲ－１３７을 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약학적 조성물
KR101721492B1 (ko) * 2014-05-26 2017-03-30 한국생명공학연구원 Ndrg3 발현 또는 활성 억제제를 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물
EP3161482B1 (fr) * 2014-06-27 2020-08-26 XY Evergreen Technology Company Procédé pour enrichir des exosomes dérivés du système nerveux central
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