CA2899449A1 - Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement - Google Patents

Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement Download PDF

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Publication number
CA2899449A1
CA2899449A1 CA2899449A CA2899449A CA2899449A1 CA 2899449 A1 CA2899449 A1 CA 2899449A1 CA 2899449 A CA2899449 A CA 2899449A CA 2899449 A CA2899449 A CA 2899449A CA 2899449 A1 CA2899449 A1 CA 2899449A1
Authority
CA
Canada
Prior art keywords
less
antibody
composition
chromatography
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2899449A
Other languages
English (en)
Inventor
Chen Wang
Germano Coppola
Christopher Chumsae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/803,808 external-priority patent/US9067990B2/en
Priority claimed from PCT/US2013/031380 external-priority patent/WO2014142882A1/fr
Priority claimed from US14/079,076 external-priority patent/US9017687B1/en
Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CA2899449A1 publication Critical patent/CA2899449A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
CA2899449A 2013-03-14 2014-03-12 Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement Abandoned CA2899449A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
USPCT/US2013/031380 2013-03-14
US13/803,808 US9067990B2 (en) 2013-03-14 2013-03-14 Protein purification using displacement chromatography
PCT/US2013/031380 WO2014142882A1 (fr) 2013-03-14 2013-03-14 Purification de protéine utilisant une chromatographie de déplacement
US13/803,808 2013-03-14
US201361892833P 2013-10-18 2013-10-18
US61/892,833 2013-10-18
US201314077576A 2013-11-12 2013-11-12
US14/077,576 2013-11-12
US14/079,076 US9017687B1 (en) 2013-10-18 2013-11-13 Low acidic species compositions and methods for producing and using the same using displacement chromatography
US14/079,076 2013-11-13
PCT/US2014/024151 WO2014159554A1 (fr) 2013-03-14 2014-03-12 Composition d'espèces faiblement acides et leurs méthodes de production utilisant la chromatographie de déplacement

Publications (1)

Publication Number Publication Date
CA2899449A1 true CA2899449A1 (fr) 2014-10-02

Family

ID=50439505

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2899449A Abandoned CA2899449A1 (fr) 2013-03-14 2014-03-12 Composition d'especes faiblement acides et leurs methodes de production utilisant la chromatographie de deplacement

Country Status (6)

Country Link
EP (1) EP2970375A1 (fr)
AU (1) AU2014240431A1 (fr)
CA (1) CA2899449A1 (fr)
HK (1) HK1213919A1 (fr)
SG (1) SG11201507365VA (fr)
WO (1) WO2014159554A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3334747T5 (da) 2015-08-13 2024-10-07 Amgen Inc Ladet dybdefiltrering af antigenbindende proteiner
WO2018027195A1 (fr) * 2016-08-05 2018-02-08 Abbvie Biotherapeutics Inc. Compositions contenant des quantités réduites d'isoformes acides de daclizumab et procédés de préparation associés

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Also Published As

Publication number Publication date
AU2014240431A1 (en) 2015-08-27
HK1213919A1 (zh) 2016-07-15
EP2970375A1 (fr) 2016-01-20
WO2014159554A1 (fr) 2014-10-02
SG11201507365VA (en) 2015-10-29

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190312