CA2906389A1 - Solution therapeutique liquide exempte de colorant - Google Patents

Solution therapeutique liquide exempte de colorant

Info

Publication number: CA2906389A1
Authority: CA; Canada
Prior art keywords: liquid composition; weight; composition; liquid; present
Prior art date: 2013-03-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2906389A

Other languages

English (en)

Inventor

Mahesh Sudhakar Bharati

Houphouet Hyacinthe Yarabe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis Healthcare Pvt Ltd

Novartis Consumer Health Inc

Original Assignee

Novartis Healthcare Pvt Ltd

Novartis Consumer Health Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-15

Filing date

2014-03-07

Publication date

2014-09-25

2014-03-07 Application filed by Novartis Healthcare Pvt Ltd, Novartis Consumer Health Inc filed Critical Novartis Healthcare Pvt Ltd

2014-03-07 Priority claimed from PCT/US2014/021590 external-priority patent/WO2014149939A1/fr

2014-09-25 Publication of CA2906389A1 publication Critical patent/CA2906389A1/fr

Status Abandoned legal-status Critical Current

Links

239000007788 liquid Substances 0.000 title claims abstract description 113
230000001225 therapeutic effect Effects 0.000 title description 8
239000000203 mixture Substances 0.000 claims abstract description 125
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 66
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 41
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 22
235000011187 glycerol Nutrition 0.000 claims abstract description 21
239000006184 cosolvent Substances 0.000 claims abstract description 12
239000008186 active pharmaceutical agent Substances 0.000 claims abstract description 8
150000005846 sugar alcohols Chemical class 0.000 claims abstract description 8
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 38
229960005489 paracetamol Drugs 0.000 claims description 19
239000003755 preservative agent Substances 0.000 claims description 17
239000002904 solvent Substances 0.000 claims description 16
238000000034 method Methods 0.000 claims description 15
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
239000006174 pH buffer Substances 0.000 claims description 11
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
239000000796 flavoring agent Substances 0.000 claims description 10
235000019634 flavors Nutrition 0.000 claims description 10
230000002335 preservative effect Effects 0.000 claims description 10
239000000600 sorbitol Substances 0.000 claims description 10
238000003860 storage Methods 0.000 claims description 10
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 8
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 7
229960002216 methylparaben Drugs 0.000 claims description 7
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 claims description 6
235000003599 food sweetener Nutrition 0.000 claims description 6
239000003765 sweetening agent Substances 0.000 claims description 6
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 5
229960001680 ibuprofen Drugs 0.000 claims description 5
208000024891 symptom Diseases 0.000 claims description 5
239000000654 additive Substances 0.000 claims description 4
230000000996 additive effect Effects 0.000 claims description 4
239000012669 liquid formulation Substances 0.000 claims description 4
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 4
239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 4
229960003415 propylparaben Drugs 0.000 claims description 4
MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims description 3
239000008135 aqueous vehicle Substances 0.000 claims description 3
229940067596 butylparaben Drugs 0.000 claims description 3
229960001985 dextromethorphan Drugs 0.000 claims description 3
-1 flavoring system Substances 0.000 claims description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 2
229960001617 ethyl hydroxybenzoate Drugs 0.000 claims 2
235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims 2
239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims 2
NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims 2
229960002146 guaifenesin Drugs 0.000 claims 2
BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 12
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
238000009472 formulation Methods 0.000 description 11
239000000546 pharmaceutical excipient Substances 0.000 description 11
239000004615 ingredient Substances 0.000 description 10
239000004480 active ingredient Substances 0.000 description 8
239000000975 dye Substances 0.000 description 7
239000008213 purified water Substances 0.000 description 7
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 6
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 5
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 5
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 4
235000009754 Vitis X bourquina Nutrition 0.000 description 4
235000012333 Vitis X labruscana Nutrition 0.000 description 4
240000006365 Vitis vinifera Species 0.000 description 4
235000014787 Vitis vinifera Nutrition 0.000 description 4
230000015556 catabolic process Effects 0.000 description 4
238000006731 degradation reaction Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 3
229960003908 pseudoephedrine Drugs 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
239000001509 sodium citrate Substances 0.000 description 3
241000167854 Bourreria succulenta Species 0.000 description 2
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
206010037660 Pyrexia Diseases 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
235000019693 cherries Nutrition 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
150000004683 dihydrates Chemical class 0.000 description 2
229940009662 edetate Drugs 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
230000000670 limiting effect Effects 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
239000000725 suspension Substances 0.000 description 2
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
241000207199 Citrus Species 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
241000663858 Corixidae Species 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
235000016623 Fragaria vesca Nutrition 0.000 description 1
240000009088 Fragaria x ananassa Species 0.000 description 1
235000011363 Fragaria x ananassa Nutrition 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
244000024873 Mentha crispa Species 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
240000008790 Musa x paradisiaca Species 0.000 description 1
235000018290 Musa x paradisiaca Nutrition 0.000 description 1
240000009023 Myrrhis odorata Species 0.000 description 1
235000007265 Myrrhis odorata Nutrition 0.000 description 1
235000012550 Pimpinella anisum Nutrition 0.000 description 1
240000007651 Rubus glaucus Species 0.000 description 1
235000011034 Rubus glaucus Nutrition 0.000 description 1
235000009122 Rubus idaeus Nutrition 0.000 description 1
239000004376 Sucralose Substances 0.000 description 1
244000299461 Theobroma cacao Species 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
101150046432 Tril gene Proteins 0.000 description 1
240000000851 Vaccinium corymbosum Species 0.000 description 1
235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
240000001717 Vaccinium macrocarpon Species 0.000 description 1
235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000003078 antioxidant effect Effects 0.000 description 1
235000021014 blueberries Nutrition 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002775 capsule Substances 0.000 description 1
235000013736 caramel Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000007958 cherry flavor Substances 0.000 description 1
235000019219 chocolate Nutrition 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000004040 coloring Methods 0.000 description 1
235000004634 cranberry Nutrition 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000000994 depressogenic effect Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940124274 edetate disodium Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
235000012907 honey Nutrition 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000004571 lime Substances 0.000 description 1
239000012263 liquid product Substances 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000010445 mica Substances 0.000 description 1
229910052618 mica group Inorganic materials 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229940100474 polyethylene glycol 1450 Drugs 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
235000010241 potassium sorbate Nutrition 0.000 description 1
239000004302 potassium sorbate Substances 0.000 description 1
229940069338 potassium sorbate Drugs 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000013341 scale-up Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000001334 starch sodium octenyl succinate Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA2906389A 2013-03-15 2014-03-07 Solution therapeutique liquide exempte de colorant Abandoned CA2906389A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN765/DEL/2013		2013-03-15
IN765DE2013		2013-03-15
PCT/US2014/021590 WO2014149939A1 (fr)	2013-03-15	2014-03-07	Solution thérapeutique liquide exempte de colorant

Publications (1)

Publication Number	Publication Date
CA2906389A1 true CA2906389A1 (fr)	2014-09-25

Family

ID=54258944

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2906389A Abandoned CA2906389A1 (fr)	2013-03-15	2014-03-07	Solution therapeutique liquide exempte de colorant

Country Status (4)

Country	Link
EP (1)	EP2968573A1 (fr)
CN (1)	CN105263524A (fr)
CA (1)	CA2906389A1 (fr)
SG (1)	SG11201507369WA (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN110115708A (zh) *	2018-02-07	2019-08-13	保瑞药业股份有限公司	乙酰胺酚及曲马多共溶复方止痛口服液

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0714872B2 (ja) *	1990-02-06	1995-02-22	昭和薬品化工株式会社	シロップ剤組成物
US5505961A (en) *	1993-08-05	1996-04-09	R. P. Scherer Corporation	Gelatin capsules containing a highly concentrated acetaminophen solution
US5616621A (en) *	1995-01-30	1997-04-01	American Home Products Corporation	Taste masking liquids
AU2002356831B2 (en) *	2001-10-22	2006-06-08	Taro Pharmaceutical Industries Ltd.	Taste masking spill-resistant formulation
US20080085892A1 (en) *	2006-08-31	2008-04-10	Sangeetha Kandeepan	Liquid dosage form of acetaminophen

2014
- 2014-03-07 CN CN201480015663.9A patent/CN105263524A/zh active Pending
- 2014-03-07 SG SG11201507369WA patent/SG11201507369WA/en unknown
- 2014-03-07 EP EP14714047.9A patent/EP2968573A1/fr not_active Withdrawn
- 2014-03-07 CA CA2906389A patent/CA2906389A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
EP2968573A1 (fr)	2016-01-20
SG11201507369WA (en)	2015-10-29
CN105263524A (zh)	2016-01-20

Legal Events

Date	Code	Title	Description
2019-04-18	FZDE	Discontinued	Effective date: 20190307

Publication	Publication Date	Title
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HU230456B1 (hu)	2016-07-28	Aripiprazol orális oldatai
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US11771706B2 (en)	2023-10-03	Oral solutions comprising fludrocortisone acetate
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