CA2919498C - Aerosol nintedanib compounds and uses thereof - Google Patents

Aerosol nintedanib compounds and uses thereof Download PDF

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Publication number
CA2919498C
CA2919498C CA2919498A CA2919498A CA2919498C CA 2919498 C CA2919498 C CA 2919498C CA 2919498 A CA2919498 A CA 2919498A CA 2919498 A CA2919498 A CA 2919498A CA 2919498 C CA2919498 C CA 2919498C
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CA
Canada
Prior art keywords
salt
imatinib
kinase inhibitor
tyrosine kinase
phenylaminopyrimidine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2919498A
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English (en)
French (fr)
Other versions
CA2919498A1 (en
Inventor
Mark William Surber
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Avalyn Pharma Inc
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Avalyn Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalyn Pharma Inc filed Critical Avalyn Pharma Inc
Priority to CA3172586A priority Critical patent/CA3172586C/en
Publication of CA2919498A1 publication Critical patent/CA2919498A1/en
Application granted granted Critical
Publication of CA2919498C publication Critical patent/CA2919498C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
CA2919498A 2013-07-31 2014-07-31 Aerosol nintedanib compounds and uses thereof Active CA2919498C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3172586A CA3172586C (en) 2013-07-31 2014-07-31 IMATINIB AEROSOL COMPOUNDS AND RELATED USES

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361860721P 2013-07-31 2013-07-31
US61/860,721 2013-07-31
US201461948461P 2014-03-05 2014-03-05
US61/948,461 2014-03-05
PCT/US2014/049294 WO2015017728A1 (en) 2013-07-31 2014-07-31 Aerosol tyrosine kinase inhibitor compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3172586A Division CA3172586C (en) 2013-07-31 2014-07-31 IMATINIB AEROSOL COMPOUNDS AND RELATED USES

Publications (2)

Publication Number Publication Date
CA2919498A1 CA2919498A1 (en) 2015-02-05
CA2919498C true CA2919498C (en) 2023-07-25

Family

ID=52432447

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2919498A Active CA2919498C (en) 2013-07-31 2014-07-31 Aerosol nintedanib compounds and uses thereof
CA3280124A Pending CA3280124A1 (en) 2013-07-31 2014-07-31 Aerosol imatinib compounds and uses thereof
CA3172586A Active CA3172586C (en) 2013-07-31 2014-07-31 IMATINIB AEROSOL COMPOUNDS AND RELATED USES

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3280124A Pending CA3280124A1 (en) 2013-07-31 2014-07-31 Aerosol imatinib compounds and uses thereof
CA3172586A Active CA3172586C (en) 2013-07-31 2014-07-31 IMATINIB AEROSOL COMPOUNDS AND RELATED USES

Country Status (7)

Country Link
US (5) US20150044288A1 (2)
EP (2) EP3782604A1 (2)
JP (8) JP6799201B2 (2)
AU (5) AU2014296032A1 (2)
CA (3) CA2919498C (2)
ES (1) ES3010397T3 (2)
WO (1) WO2015017728A1 (2)

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US11166953B2 (en) 2017-04-17 2021-11-09 Yale University Compounds, compositions and methods of treating or preventing acute lung injury
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JP2023544685A (ja) * 2020-09-14 2023-10-25 イスタンブル ウニヴェルシテシ レクトールルグ 吸入ルートを介するソフトミスト吸入器又は振動型メッシュ式噴霧器を用いた新型コロナウイルス感染症を含むウイルス性肺疾患の治療における抗ウイルス性、抗マラリア性及び／又は粘液溶解性を備える活性物質の使用
CA3097717A1 (en) * 2020-11-02 2022-05-02 Skymount Medical Us Inc. TYROSINE KINASE IN THE TREATMENT OF CORONAVIRUS DISEASES
CN116916889A (zh) * 2020-11-17 2023-10-20 联合治疗公司 用于肺高压领域的吸入式伊马替尼
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CN117098557A (zh) * 2020-11-23 2023-11-21 埃渃维特治疗学公司 伊马替尼调配物、其制备和用途
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