IT1204826B - Composizioni farmaceutiche per inalazione - Google Patents
Composizioni farmaceutiche per inalazioneInfo
- Publication number
- IT1204826B IT1204826B IT19625/86A IT1962586A IT1204826B IT 1204826 B IT1204826 B IT 1204826B IT 19625/86 A IT19625/86 A IT 19625/86A IT 1962586 A IT1962586 A IT 1962586A IT 1204826 B IT1204826 B IT 1204826B
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical compositions
- inhalation pharmaceutical
- inhalation
- microgranules
- conglomerate
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19625/86A IT1204826B (it) | 1986-03-04 | 1986-03-04 | Composizioni farmaceutiche per inalazione |
| EP87102816A EP0239798B1 (en) | 1986-03-04 | 1987-02-27 | New pharmaceutical compositions for inhalation |
| DE198787901468T DE258356T1 (de) | 1986-03-04 | 1987-02-27 | Pharmazeutische zusammensetzungen zum einatmen. |
| JP62501911A JPS63502895A (ja) | 1986-03-04 | 1987-02-27 | 新規な吸入用製薬組成物 |
| AT87901468T ATE94755T1 (de) | 1986-03-04 | 1987-02-27 | Pharmazeutische zusammensetzungen zum einatmen. |
| AU71645/87A AU597964B2 (en) | 1986-03-04 | 1987-02-27 | New pharmaceutical compositions for inhalation |
| DE87901468T DE3787502T2 (de) | 1986-03-04 | 1987-02-27 | Pharmazeutische zusammensetzungen zum einatmen. |
| HU871760A HU202748B (en) | 1986-03-04 | 1987-02-27 | Process for producing filling material usable in inhalation pharmaceutical compositions |
| KR1019870701005A KR940000099B1 (ko) | 1986-03-04 | 1987-02-27 | 신규 흡입용 제약 조성물 |
| ES198787102816T ES2031839T3 (es) | 1986-03-04 | 1987-02-27 | Nuevas composiciones farmaceuticas para inhalacion. |
| EP87901468A EP0258356B1 (en) | 1986-03-04 | 1987-02-27 | New pharmaceutical compositions for inhalation |
| PCT/EP1987/000118 WO1987005213A1 (en) | 1986-03-04 | 1987-02-27 | New pharmaceutical compositions for inhalation |
| ZA871523A ZA871523B (en) | 1986-03-04 | 1987-03-03 | Pharmaceutical compositions for inhalation |
| CA000531054A CA1297012C (en) | 1986-03-04 | 1987-03-03 | Pharmaceutical compositions for inhalation |
| NZ219484A NZ219484A (en) | 1986-03-04 | 1987-03-03 | Microgranular excipient for inhalation |
| MYPI87002294A MY102928A (en) | 1986-03-04 | 1987-09-29 | New pharmaceutical compositions for inhalation |
| FI874710A FI90015C (fi) | 1986-03-04 | 1987-10-26 | Fyllnadsaemne och dess anvaendning i farmaceutiska sammansaettningar foer inhalation |
| NO874590A NO874590L (no) | 1986-03-04 | 1987-11-03 | Brer fra farmaceutiske blandinger. |
| GR88300017T GR880300017T1 (en) | 1986-03-04 | 1988-05-20 | New pharmaceutical compositions for inhalation |
| GR90400695T GR3000879T3 (en) | 1986-03-04 | 1990-09-27 | New pharmaceutical compositions for inhalation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19625/86A IT1204826B (it) | 1986-03-04 | 1986-03-04 | Composizioni farmaceutiche per inalazione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8619625A0 IT8619625A0 (it) | 1986-03-04 |
| IT1204826B true IT1204826B (it) | 1989-03-10 |
Family
ID=11159814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT19625/86A IT1204826B (it) | 1986-03-04 | 1986-03-04 | Composizioni farmaceutiche per inalazione |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0258356B1 (it) |
| JP (1) | JPS63502895A (it) |
| KR (1) | KR940000099B1 (it) |
| AT (1) | ATE94755T1 (it) |
| AU (1) | AU597964B2 (it) |
| CA (1) | CA1297012C (it) |
| DE (2) | DE258356T1 (it) |
| ES (1) | ES2031839T3 (it) |
| FI (1) | FI90015C (it) |
| GR (2) | GR880300017T1 (it) |
| HU (1) | HU202748B (it) |
| IT (1) | IT1204826B (it) |
| MY (1) | MY102928A (it) |
| NO (1) | NO874590L (it) |
| NZ (1) | NZ219484A (it) |
| WO (1) | WO1987005213A1 (it) |
| ZA (1) | ZA871523B (it) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
| US5270305A (en) | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
| US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| GB9001635D0 (en) * | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
| SE9101090D0 (sv) * | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
| JPH0558911A (ja) * | 1991-08-27 | 1993-03-09 | N D Shinyaku Kaihatsu Kenkyusho:Kk | 鎮咳去痰剤 |
| US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| AUPM411494A0 (en) * | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| DE4425255A1 (de) | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| SE9404468D0 (sv) * | 1994-12-22 | 1994-12-22 | Astra Ab | Powder formulations |
| EP0806940B1 (en) | 1994-12-22 | 2003-04-09 | AstraZeneca AB | Aerosol drug formulations |
| US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US6503537B2 (en) * | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
| US6599883B1 (en) * | 1998-10-30 | 2003-07-29 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of xylitol |
| AU756852B2 (en) * | 1998-11-13 | 2003-01-23 | Jagotec Ag | Dry powder for inhalation |
| ES2286881T3 (es) | 1999-03-05 | 2007-12-01 | Chiesi Farmaceutici S.P.A. | Composiciones farmaceuticas en polvo mejoradas para inhalacion. |
| ITMI991582A1 (it) | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0009469D0 (en) | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| CA2413692C (en) * | 2000-06-27 | 2011-10-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| PT1296651E (pt) * | 2000-06-27 | 2008-02-12 | Vectura Ltd | Método para fazer partículas para serem usadas numa composição farmacêutica |
| EP2283818B1 (en) * | 2000-11-30 | 2017-08-02 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| EP2168571B1 (en) | 2000-11-30 | 2018-08-22 | Vectura Limited | Particles for use in a Pharmaceutical Composition |
| NZ526059A (en) † | 2000-11-30 | 2005-05-27 | Vectura Ltd | Method of making composite active particles in the presence of an additive material for use in a pharmaceutical composition |
| US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
| DE10141377A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| DE10141376A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Inhalationspulvern |
| WO2003024396A2 (en) | 2001-09-17 | 2003-03-27 | Glaxo Group Limited | Dry powder medicament formulations |
| JP2005508220A (ja) * | 2001-10-24 | 2005-03-31 | パーリ・ゲーエムベーハー | 薬用組成物調製用具 |
| EP1417961A1 (en) * | 2002-11-08 | 2004-05-12 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions containing a combination of ambroxol or bromhexine and isopropamide iodide |
| JP2009513529A (ja) * | 2003-07-11 | 2009-04-02 | グラクソ グループ リミテッド | ステアリン酸マグネシウムを含む医薬製剤 |
| TW200519108A (en) | 2003-07-17 | 2005-06-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| AP2007004239A0 (en) | 2003-10-14 | 2007-12-31 | Glaxo Group Ltd | Muscarinic acetycholine receptor antagonists |
| BRPI0415281A (pt) | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
| PE20050489A1 (es) | 2003-11-04 | 2005-09-02 | Glaxo Group Ltd | Antagonistas de receptores de acetilcolina muscarinicos |
| GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| WO2005095407A1 (en) | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| PE20060259A1 (es) | 2004-04-27 | 2006-03-25 | Glaxo Group Ltd | Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico |
| JP2007537261A (ja) | 2004-05-13 | 2007-12-20 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
| EP1901749B1 (en) | 2005-05-18 | 2016-08-03 | Raptor Pharmaceuticals Inc. | Aerosolized fluoroquinolones and uses thereof |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| WO2007022351A2 (en) | 2005-08-18 | 2007-02-22 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
| US7832397B2 (en) | 2005-12-28 | 2010-11-16 | Philip Morris Usa Inc. | Aerosol powder delivery device |
| GB0605723D0 (en) | 2006-03-23 | 2006-05-03 | 3M Innovative Properties Co | Powder filling processes |
| EP2346509B1 (en) | 2008-10-07 | 2020-05-13 | Horizon Orphan LLC | Inhalation of levofloxacin for reducing lung inflammation |
| JP2012505223A (ja) | 2008-10-07 | 2012-03-01 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 薬物動態の改善のためのエアゾールフルオロキノロン配合物 |
| LT2400950T (lt) | 2009-02-26 | 2019-08-26 | Glaxo Group Limited | Farmacinės kompozicijos, apimančios 4-{(1 r)-2-[(6-{2-[(2,6-dichlorbenzil)oksi]etoksi}heksil)amino]-1-hidroksetil}-2-(hidroksimetil)fenolį |
| RU2563809C2 (ru) | 2009-09-04 | 2015-09-20 | Мпекс Фармасьютикалс, Инк. | Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза |
| GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| WO2011131663A1 (en) * | 2010-04-21 | 2011-10-27 | Chiesi Farmaceutici S.P.A. | "process for providing particles with reduced electrostatic charges" |
| TR201007250A2 (tr) | 2010-09-01 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Selobioz içeren formülasyon. |
| UY33337A (es) | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
| JP6021117B2 (ja) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ,インク. | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| NZ628072A (en) | 2012-03-13 | 2015-08-28 | Respivert Ltd | Crystalline pi3 kinase inhibitors |
| EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
| EP2874928B1 (en) | 2012-07-19 | 2016-06-15 | Adamis Pharmaceuticals Corporation | Powder feeding apparatus |
| GB201305825D0 (en) | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| DE102016218604A1 (de) | 2016-09-27 | 2018-03-29 | Constantin Adams | Partikuläres Stoffgemisch, vorzugsweise zur Verwendung bei der Prophylaxe und/oder Behandlung einer Atemwegsstörung |
| WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
| WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
| WO2023128916A1 (en) * | 2021-12-31 | 2023-07-06 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | An apparatus with a grid (10) for the preparation of dry powder compositions for inhalation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957965A (en) * | 1967-08-08 | 1976-05-18 | Fisons Limited | Sodium chromoglycate inhalation medicament |
| DE3012136C2 (de) * | 1980-03-28 | 1984-02-16 | Bauer, Kurt Heinz, Prof. Dr., 7800 Freiburg | Verfahren zur Herstellung eines Granulats |
-
1986
- 1986-03-04 IT IT19625/86A patent/IT1204826B/it active
-
1987
- 1987-02-27 DE DE198787901468T patent/DE258356T1/de active Pending
- 1987-02-27 AT AT87901468T patent/ATE94755T1/de not_active IP Right Cessation
- 1987-02-27 JP JP62501911A patent/JPS63502895A/ja active Pending
- 1987-02-27 DE DE87901468T patent/DE3787502T2/de not_active Expired - Fee Related
- 1987-02-27 EP EP87901468A patent/EP0258356B1/en not_active Expired - Lifetime
- 1987-02-27 KR KR1019870701005A patent/KR940000099B1/ko not_active Expired - Lifetime
- 1987-02-27 EP EP87102816A patent/EP0239798B1/en not_active Expired - Lifetime
- 1987-02-27 HU HU871760A patent/HU202748B/hu not_active IP Right Cessation
- 1987-02-27 ES ES198787102816T patent/ES2031839T3/es not_active Expired - Lifetime
- 1987-02-27 WO PCT/EP1987/000118 patent/WO1987005213A1/en not_active Ceased
- 1987-02-27 AU AU71645/87A patent/AU597964B2/en not_active Ceased
- 1987-03-03 CA CA000531054A patent/CA1297012C/en not_active Expired - Lifetime
- 1987-03-03 NZ NZ219484A patent/NZ219484A/xx unknown
- 1987-03-03 ZA ZA871523A patent/ZA871523B/xx unknown
- 1987-09-29 MY MYPI87002294A patent/MY102928A/en unknown
- 1987-10-26 FI FI874710A patent/FI90015C/fi not_active IP Right Cessation
- 1987-11-03 NO NO874590A patent/NO874590L/no unknown
-
1988
- 1988-05-20 GR GR88300017T patent/GR880300017T1/el unknown
-
1990
- 1990-09-27 GR GR90400695T patent/GR3000879T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0258356B1 (en) | 1993-09-22 |
| ES2031839T3 (es) | 1993-01-01 |
| AU597964B2 (en) | 1990-06-14 |
| FI874710L (fi) | 1987-10-26 |
| FI874710A0 (fi) | 1987-10-26 |
| HUT46533A (en) | 1988-11-28 |
| ZA871523B (en) | 1987-08-24 |
| EP0239798A1 (en) | 1987-10-07 |
| FI90015C (fi) | 1993-12-27 |
| GR3000879T3 (en) | 1991-11-15 |
| WO1987005213A1 (en) | 1987-09-11 |
| NO874590D0 (no) | 1987-11-03 |
| GR880300017T1 (en) | 1988-10-18 |
| EP0239798B1 (en) | 1990-09-26 |
| NZ219484A (en) | 1989-10-27 |
| FI90015B (fi) | 1993-09-15 |
| KR880700666A (ko) | 1988-04-11 |
| KR940000099B1 (ko) | 1994-01-05 |
| ATE94755T1 (de) | 1993-10-15 |
| DE258356T1 (de) | 1988-09-01 |
| JPS63502895A (ja) | 1988-10-27 |
| EP0258356A1 (en) | 1988-03-09 |
| HU202748B (en) | 1991-04-29 |
| NO874590L (no) | 1987-12-30 |
| DE3787502T2 (de) | 1994-01-20 |
| AU7164587A (en) | 1987-09-28 |
| DE3787502D1 (de) | 1993-10-28 |
| IT8619625A0 (it) | 1986-03-04 |
| MY102928A (en) | 1993-03-31 |
| CA1297012C (en) | 1992-03-10 |
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