CA2949984C - Systemes et procedes d'analyse biochimique comprenant un instrument de base et une cartouche amovible - Google Patents

Systemes et procedes d'analyse biochimique comprenant un instrument de base et une cartouche amovible Download PDF

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Publication number
CA2949984C
CA2949984C CA2949984A CA2949984A CA2949984C CA 2949984 C CA2949984 C CA 2949984C CA 2949984 A CA2949984 A CA 2949984A CA 2949984 A CA2949984 A CA 2949984A CA 2949984 C CA2949984 C CA 2949984C
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Prior art keywords
valve
removable cartridge
cartridge
flow
housing
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CA2949984A
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English (en)
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CA2949984A1 (fr
Inventor
Alex Aravanis
Boyan Boyanov
M. Shane Bowen
Dale Buermann
Alexander HSIAO
Behnam Javanmardi
Tarun Khurana
Poorya Sabounchi
Hai Quang Tran
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Illumina Inc
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Illumina Inc
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Priority to CA3127071A priority Critical patent/CA3127071A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0013—Rotary valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des systèmes et des procédés pour mener des réactions désignées au moyen d'un instrument de base et d'une cartouche amovible. La cartouche amovible comprend un réseau fluidique qui reçoit et dirige de manière fluidique un échantillon biologique pour mener les réactions désignées. La cartouche amovible comprend également une soupape de régulation du débit qui est couplée de façon opérationnelle au réseau fluidique et est mobile par rapport au réseau fluidique pour réguler le débit de l'échantillon biologique qui s'y écoule. La cartouche amovible est configurée pour pouvoir se coupler et se séparer d'un instrument de base. L'instrument de base comprend un actionneur de soupape qui se couple à la soupape de régulation de débit de la cartouche amovible. Un ensemble de détection supporté par au moins un élément parmi la cartouche amovible ou l'instrument de base peut être utilisé pour détecter les réactions désignées.
CA2949984A 2014-05-27 2015-05-27 Systemes et procedes d'analyse biochimique comprenant un instrument de base et une cartouche amovible Active CA2949984C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3127071A CA3127071A1 (en) 2014-05-27 2015-05-27 Systems and methods for biochemical analysis including a base instrument and a removable cartridge

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462003264P 2014-05-27 2014-05-27
US62/003,264 2014-05-27
PCT/US2015/032545 WO2015183871A1 (fr) 2014-05-27 2015-05-27 Systèmes et procédés d'analyse biochimique comprenant un instrument de base et une cartouche amovible

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3127071A Division CA3127071A1 (en) 2014-05-27 2015-05-27 Systems and methods for biochemical analysis including a base instrument and a removable cartridge

Publications (2)

Publication Number Publication Date
CA2949984A1 CA2949984A1 (fr) 2015-12-03
CA2949984C true CA2949984C (fr) 2021-10-19

Family

ID=53398202

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2949984A Active CA2949984C (fr) 2014-05-27 2015-05-27 Systemes et procedes d'analyse biochimique comprenant un instrument de base et une cartouche amovible
CA3127071A Pending CA3127071A1 (en) 2014-05-27 2015-05-27 Systems and methods for biochemical analysis including a base instrument and a removable cartridge

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3127071A Pending CA3127071A1 (en) 2014-05-27 2015-05-27 Systems and methods for biochemical analysis including a base instrument and a removable cartridge

Country Status (10)

Country Link
US (4) US10427155B2 (fr)
EP (1) EP3148697A1 (fr)
JP (3) JP6960223B2 (fr)
KR (2) KR102231650B1 (fr)
CN (2) CN106536055B (fr)
AU (3) AU2015267189B2 (fr)
BR (1) BR112016027815B1 (fr)
CA (2) CA2949984C (fr)
RU (1) RU2682546C2 (fr)
WO (1) WO2015183871A1 (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
WO2016130962A1 (fr) 2015-02-13 2016-08-18 Abbott Laboratories Modules de stockage automatisés pour liquides d'analyseur de diagnostic et systèmes et procédés associés
EP3222351A1 (fr) * 2016-03-23 2017-09-27 Ecole Polytechnique Fédérale de Lausanne (EPFL) Dispositif de réseau microfluidique
WO2017165852A1 (fr) * 2016-03-24 2017-09-28 Biological Dynamics, Inc. Cartouche fluidique jetable et composants associés
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
USD803173S1 (en) * 2016-09-07 2017-11-21 EMULATE, Inc. Perfusion module lid without pressure features
EP4439045A3 (fr) 2016-10-14 2024-11-27 Illumina, Inc. Ensemble cartouche
CN108265112B (zh) * 2016-12-30 2023-04-25 深圳市真迈生物科技有限公司 对序列测定反应进行控制的方法、序列测定系统和控制装置
GB201704761D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Common line selector valve for a system
US11579073B2 (en) * 2017-02-07 2023-02-14 Nodexus Inc. Microfluidic system with combined electrical and optical detection for high accuracy particle sorting and methods thereof
US10737267B2 (en) 2017-04-04 2020-08-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
US11351541B2 (en) 2017-04-06 2022-06-07 Illumina, Inc. In-situ fluidic inspection
EP3606673A4 (fr) 2017-04-06 2020-10-28 Illumina, Inc. Procédé et appareil pour identifier des positions de chemin fluidique
IL270445B2 (en) 2017-05-08 2024-06-01 Biological dynamics inc Methods and systems for analyte information processing
DE102017211693A1 (de) * 2017-07-07 2019-01-10 Resuscitec Gmbh Fluidanalysemodul sowie Fluidanalysator
CN107502534B (zh) * 2017-08-08 2021-03-19 珠海创飞芯科技有限公司 生物芯片的封装结构和封装方法
US10648573B2 (en) * 2017-08-23 2020-05-12 Facebook Technologies, Llc Fluidic switching devices
EP3459632A1 (fr) * 2017-09-26 2019-03-27 Lunaphore Technologies SA Cartouche microfluidique comportant un dispositif d'échantillonnage intégré
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
WO2019126388A1 (fr) 2017-12-19 2019-06-27 Biological Dynamics, Inc. Procédés et dispositifs de détection d'analytes multiples à partir d'un échantillon biologique
TWI741658B (zh) * 2018-01-24 2021-10-01 美商伊路米納有限公司 流體緩衝
NL2020616B1 (en) * 2018-02-03 2019-08-14 Illumina Inc Cartridge with laminated manifold
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
US11255868B2 (en) 2018-02-12 2022-02-22 Electronics And Telecommunications Research Institute Fluid control equipment for bio-reaction, bio-reaction system and fluid control method for bio-reaction
US11883833B2 (en) 2018-04-02 2024-01-30 Biological Dynamics, Inc. Dielectric materials
WO2019221913A1 (fr) * 2018-05-15 2019-11-21 Illumina, Inc. Cuve à circulation à raccord flexible
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
US20230302450A1 (en) * 2018-07-17 2023-09-28 Board Of Regents, The University Of Texas System Multiplexed instrument-free bar-chart spinchip integrated with nanoparticle-mediated aptasensors for visual quantitative detection of multiple pathogens
CN110856823B (zh) * 2018-08-22 2021-01-05 厦门大学 微流控芯片及其操作方法
BR112021003395A2 (pt) * 2018-08-23 2021-05-18 Sanwa Biotech Ltd aparelho de diagnóstico portátil e método do mesmo
EP3807007A4 (fr) 2018-11-30 2022-05-04 Illumina Inc Systèmes et procédés de chauffage actif d'une cartouche
WO2020118255A1 (fr) 2018-12-07 2020-06-11 Element Biosciences, Inc. Dispositif de cellule d'écoulement et son utilisation
US20200238282A1 (en) * 2019-01-24 2020-07-30 Ge Healthcare Bio-Sciences Corp. Fluid handling apparatus for a bioprocessing system
TWI873119B (zh) * 2019-01-29 2025-02-21 美商伊路米納有限公司 流通槽及製備其之方法
JP7492200B2 (ja) 2019-03-12 2024-05-29 オックスフォード ナノポール テクノロジーズ ピーエルシー ナノ細孔センシングデバイスと操作方法およびその成形方法
AU2020273459A1 (en) 2019-05-16 2021-01-07 Illumina, Inc. Base calling using convolutions
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
WO2020236471A1 (fr) * 2019-05-17 2020-11-26 Illumina, Inc. Pompes péristaltiques linéaires destinées à être utilisées avec des cartouches fluidiques
WO2020243077A1 (fr) 2019-05-31 2020-12-03 Illumina, Inc. Cytomètre en flux avec une ou plusieurs fonctionnalités de barrière
CN111111798A (zh) * 2019-06-04 2020-05-08 厦门大学 微流控检测芯片
TWI860366B (zh) * 2019-06-19 2024-11-01 美商伊路米納有限公司 儀器中的試劑交換
US12385874B2 (en) 2019-08-12 2025-08-12 Trustees Of Tufts College Modularized field-effect transistor biosensors
WO2021081472A1 (fr) * 2019-10-25 2021-04-29 Fabrico Technology Inc Systèmes et procédés de mesure de réactions colorimétriques
TWI902731B (zh) * 2019-12-30 2025-11-01 美商伊路米納有限公司 與流動池一同使用之致動系統及設備
WO2021173439A1 (fr) * 2020-02-27 2021-09-02 Illumina, Inc. Canal d'écoulement fluidique sur une surface active d'une puce
DE102020115728A1 (de) * 2020-06-15 2021-12-16 Agilent Technologies, Inc. Mikrofluidisches Bauteil mit Metallschichtstapel und damit gebondetem Fluidleitungselement aus anderem Material
EP4675256A3 (fr) 2020-07-17 2026-01-28 Oxford Nanopore Technologies PLC Dispositif de détection à nanopores
CN114308145A (zh) * 2020-09-30 2022-04-12 新加坡正煦诊断有限公司 微流体装置、试剂盒及其制备方法
CN116888273A (zh) * 2020-10-19 2023-10-13 富默乐国际控股有限公司 用于样本至结果pcr分析的具有流体通道几何形状的装置及其使用方法
US20220134336A1 (en) * 2020-10-30 2022-05-05 EGI Tech (Qing Dao) Co., Limited Sequencing systems including a base unit and removable cartridge
US20230356230A1 (en) * 2021-03-03 2023-11-09 Illumina, Inc. Reagent cartridges and related systems and methods for controlling reagent temperature
GB202105909D0 (en) * 2021-04-26 2021-06-09 Cytiva Sweden Ab Gb2105909.2
TWI785636B (zh) 2021-06-07 2022-12-01 新加坡商克雷多生醫有限公司 檢測卡匣
GB2629259B (en) 2021-07-21 2025-05-28 Element Biosciences Inc Optical systems for nucleic acid sequencing and methods thereof
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
CN115025729A (zh) * 2022-05-31 2022-09-09 利穗科技(苏州)有限公司 一种新型的寡核酸合成系统
WO2024088766A1 (fr) * 2022-10-25 2024-05-02 Dyconex Ag Dispositif de laboratoire sur carte de circuit imprimé (pcb) et son procédé de fabrication
WO2024102971A2 (fr) * 2022-11-11 2024-05-16 Synthego Corporation Appareil et procédés de manipulation microfluidique de fluides à l'aide de systèmes de vanne
WO2025012428A1 (fr) * 2023-07-13 2025-01-16 Curetis Gmbh Cartouche de manipulation d'au moins une substance, articles et procédés correspondants
WO2025137109A1 (fr) * 2023-12-20 2025-06-26 Abbott Point Of Care Inc. Cmp du sang total dans un dispositif dmf sans dilution
DE102024202356A1 (de) * 2024-03-13 2025-09-18 Robert Bosch Gesellschaft mit beschränkter Haftung Modulares System für eine mikrofluidische Kartusche, insbesondere zur Analyse einer biologischen Probe
WO2025212883A1 (fr) * 2024-04-03 2025-10-09 Xellar, Inc. Systèmes et procédés de commande de perfusion dans des dispositifs microfluidiques

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450060A1 (fr) 1989-10-26 1991-10-09 Sri International Sequen age d'adn
JPH08500052A (ja) * 1992-07-06 1996-01-09 ベックマン インスツルメンツ インコーポレーテッド 多重ポート弁を使用する流体配送装置
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
EP1498494A3 (fr) 1997-04-01 2007-06-20 Solexa Ltd. Procédé de séquencage d'acides nucléiques
EP1591541B1 (fr) 1997-04-01 2012-02-15 Illumina Cambridge Limited Methode de séquençage d'acide nucléique
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US6335546B1 (en) * 1998-07-31 2002-01-01 Sharp Kabushiki Kaisha Nitride semiconductor structure, method for producing a nitride semiconductor structure, and light emitting device
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US20050191698A1 (en) 1999-04-20 2005-09-01 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
DE60029582T3 (de) 1999-05-28 2012-03-08 Cepheid Patrone zum durchführen einer chemischen reaktion
AU780073B2 (en) 1999-05-28 2005-02-24 Cepheid Apparatus and method for cell disruption
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8518328B2 (en) * 2005-12-27 2013-08-27 Honeywell International Inc. Fluid sensing and control in a fluidic analyzer
ATE377093T1 (de) 2000-07-07 2007-11-15 Visigen Biotechnologies Inc Sequenzbestimmung in echtzeit
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
AU2001294922A1 (en) 2000-10-02 2002-04-15 Thomas F. Cannon Automated bioculture and bioculture experiments system
US8900811B2 (en) * 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
DK1258720T3 (da) * 2001-05-15 2007-11-12 Sysmex Corp Måleenhed og roterende ventil til anvendelse deri
US7459302B2 (en) * 2001-10-02 2008-12-02 Stratagene California Side-wall heater for thermocycler device
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
EP2607369B1 (fr) 2002-08-23 2015-09-23 Illumina Cambridge Limited Nucléotides modifiés pour le séquençage de polynucléotide
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
WO2004079342A2 (fr) * 2003-03-03 2004-09-16 Hts Biosystems, Inc. Mimetiques d'acides nucleiques pour reference interne et etalonnage dans une methode d'analyse de liaisons sur microreseau dans une cuve a circulation
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
US20110059865A1 (en) 2004-01-07 2011-03-10 Mark Edward Brennan Smith Modified Molecular Arrays
JP4179169B2 (ja) 2004-01-08 2008-11-12 カシオ計算機株式会社 分析装置
US20060062531A1 (en) 2004-09-17 2006-03-23 Stephen Turner Fabrication of optical confinements
EP1828412B2 (fr) 2004-12-13 2019-01-09 Illumina Cambridge Limited Procede ameliore de detection de nucleotides
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US8623628B2 (en) 2005-05-10 2014-01-07 Illumina, Inc. Polymerases
JP4661386B2 (ja) * 2005-06-20 2011-03-30 船井電機株式会社 受信装置
US7215584B2 (en) * 2005-07-01 2007-05-08 Lsi Logic Corporation Method and/or apparatus for training DQS strobe gating
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
US7955864B2 (en) * 2005-08-22 2011-06-07 Life Technologies Corporation Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
EP2021503A1 (fr) 2006-03-17 2009-02-11 Solexa Ltd. Procédés isothermiques pour créer des réseaux moléculaires clonales simples
WO2007123744A2 (fr) 2006-03-31 2007-11-01 Solexa, Inc. Systèmes et procédés pour analyse de séquençage par synthèse
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
EP2639578B1 (fr) 2006-12-14 2016-09-14 Life Technologies Corporation Appareil de mesure d'analytes à l'aide de matrices de FET à grande échelle
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
JP2009002899A (ja) * 2007-06-25 2009-01-08 Akita Prefecture 検出装置
DE102007053672A1 (de) * 2007-11-10 2009-05-20 Daimler Ag Lenksäulenanordnung für Kraftwagen
JP2010075072A (ja) 2008-09-24 2010-04-08 Toshiba Corp 核酸検出カセット
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CA2764678C (fr) * 2009-06-04 2017-12-12 Lockheed Martin Corporation Puce microfluidique a echantillons multiples pour l'analyse d'adn
DE102009037921B4 (de) * 2009-08-19 2014-02-13 Carl Zeiss Meditec Ag Tubus für Operationsmikroskop
US10034829B2 (en) 2010-10-27 2018-07-31 Noxell Corporation Semi-permanent mascara compositions
DK2504105T3 (da) * 2009-11-24 2021-03-15 Opko Diagnostics Llc Fluidblanding og -afgivelse i mikrofluidsystemer
EP3514519B1 (fr) * 2009-12-07 2022-02-09 Meso Scale Technologies, LLC. Cartouches de test
FR2955119B1 (fr) * 2010-01-13 2012-12-28 Millipore Corp Circuit pour liquide biologique
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
JP5562278B2 (ja) * 2011-03-15 2014-07-30 株式会社神戸製鋼所 タイヤ形状検査装置、及びタイヤ形状検査方法
US8574513B2 (en) * 2011-04-20 2013-11-05 California Institute Of Technology Single-layer PCB microfluidics
CN102917566A (zh) 2011-08-01 2013-02-06 富瑞精密组件（昆山）有限公司 散热器
EP3623481B1 (fr) 2011-09-23 2021-08-25 Illumina, Inc. Compositions de séquençage d'acide nucléique
CA2854023A1 (fr) 2011-11-07 2013-05-16 Illumina, Inc. Appareils de sequencage integre et procedes d'utilisation
CA3138752C (fr) * 2012-04-03 2024-02-06 Illumina, Inc. Tete de lecture optoelectronique integree et cartouche fluidique utile pour le sequencage d'acide nucleique
US8906320B1 (en) * 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
EP2870391B1 (fr) 2012-07-05 2019-03-27 Meso Scale Technologies, LLC Système de soupape de cartouche d'analyse
RU2532176C2 (ru) * 2012-07-09 2014-10-27 Владимир Николаевич Кононов Биореактор модульный
CN104737024B (zh) * 2012-09-05 2018-01-09 塞弗德公司 流体分析系统中的通用对接站和数据门
CA2900215A1 (fr) 2013-03-15 2014-09-18 Illumina, Inc. Systeme et procede pour generer ou analyser un echantillon biologique
CN110982689A (zh) 2014-03-11 2020-04-10 伊鲁米那股份有限公司 一次性的集成微流体盒及其制备和使用的方法

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