CA2950433C - Glycoanticorps anti-thf-alpha et leurs utilisations - Google Patents

Glycoanticorps anti-thf-alpha et leurs utilisations

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Publication number
CA2950433C
CA2950433C CA2950433A CA2950433A CA2950433C CA 2950433 C CA2950433 C CA 2950433C CA 2950433 A CA2950433 A CA 2950433A CA 2950433 A CA2950433 A CA 2950433A CA 2950433 C CA2950433 C CA 2950433C
Authority
CA
Canada
Prior art keywords
tnf
tnfa
antibody
disease
glycan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2950433A
Other languages
English (en)
Other versions
CA2950433A1 (fr
Inventor
Chi-Huey Wong
Chung-Yi Wu
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Priority claimed from PCT/US2015/032737 external-priority patent/WO2015184001A1/fr
Publication of CA2950433A1 publication Critical patent/CA2950433A1/fr
Application granted granted Critical
Publication of CA2950433C publication Critical patent/CA2950433C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne une nouvelle classe d'anticorps monoclonaux anti-TNFα ou des fragments de liaison de l'antigène comprenant une population homogène de molécules IgG anti-TNFα ayant le même N-glycane sur chaque Fc. Les anticorps de l'invention peut être produits à partir d'anticorps monoclonaux anti-TNFα par glycomodification de Fc. Les glycoanticorps de l'invention peuvent avoir des valeurs thérapeutique améliorées par rapport à celles d'anticorps monoclonaux correspondants qui n'ont pas été glycomodifiés.
CA2950433A 2014-05-28 2015-05-27 Glycoanticorps anti-thf-alpha et leurs utilisations Active CA2950433C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462003908P 2014-05-28 2014-05-28
US62/003,908 2014-05-28
US201462020199P 2014-07-02 2014-07-02
US62/020,199 2014-07-02
US201562110338P 2015-01-30 2015-01-30
US62/110,338 2015-01-30
PCT/US2015/032737 WO2015184001A1 (fr) 2014-05-28 2015-05-27 Glycoanticorps anti-thf-alpha et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2950433A1 CA2950433A1 (fr) 2015-12-03
CA2950433C true CA2950433C (fr) 2025-11-18

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CA2950433C (fr) Glycoanticorps anti-thf-alpha et leurs utilisations