CA2960031A1 - Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia - Google Patents

Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia Download PDF

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Publication number
CA2960031A1
CA2960031A1 CA2960031A CA2960031A CA2960031A1 CA 2960031 A1 CA2960031 A1 CA 2960031A1 CA 2960031 A CA2960031 A CA 2960031A CA 2960031 A CA2960031 A CA 2960031A CA 2960031 A1 CA2960031 A1 CA 2960031A1
Authority
CA
Canada
Prior art keywords
dextromethorphan
salts
quinidine
administered
deuterated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2960031A
Other languages
English (en)
French (fr)
Inventor
Joao Siffert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avanir Pharmaceuticals Inc
Original Assignee
Avanir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Publication of CA2960031A1 publication Critical patent/CA2960031A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2960031A 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia Pending CA2960031A1 (en)

Applications Claiming Priority (35)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US62/050,170 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US62/061,451 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US62/063,122 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US62/063,861 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US62/068,742 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US62/111,053 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US62/111,590 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US62/128,446 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US62/162,140 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US62/165,535 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US62/169,997 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US62/180,026 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US62/193,347 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US62/205,061 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US62/216,636 2015-09-10
US201562217142P 2015-09-11 2015-09-11
US201562217470P 2015-09-11 2015-09-11
US62/217,470 2015-09-11
US62/217,142 2015-09-11
PCT/US2015/049934 WO2016040930A1 (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Publications (1)

Publication Number Publication Date
CA2960031A1 true CA2960031A1 (en) 2016-03-17

Family

ID=55459653

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2960031A Pending CA2960031A1 (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Country Status (15)

Country Link
US (3) US20190111047A1 (2)
EP (4) EP3193872A4 (2)
JP (4) JP2017531033A (2)
KR (1) KR20170052684A (2)
CN (3) CN117427077A (2)
AU (3) AU2015314710A1 (2)
CA (1) CA2960031A1 (2)
IL (2) IL250786A0 (2)
MX (3) MX2017003066A (2)
MY (1) MY198587A (2)
PH (1) PH12017500444A1 (2)
RU (1) RU2017112747A (2)
SG (2) SG11201701645WA (2)
TW (3) TW202106301A (2)
WO (1) WO2016040930A1 (2)

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CN115245515A (zh) * 2021-04-27 2022-10-28 杭州剂泰医药科技有限责任公司 一种组合物的医药用途
CN115322150B (zh) * 2021-05-11 2024-05-28 深圳信立泰药业股份有限公司 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途
CN113209042A (zh) * 2021-05-28 2021-08-06 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法
IL312310A (en) * 2021-10-27 2024-06-01 Avanir Pharmaceuticals Inc Methods for treating agitation associated with Alzheimer's disease
CN116459255A (zh) * 2022-01-19 2023-07-21 深圳信立泰药业股份有限公司 氘代右美沙芬与安非他酮联合在制备ad激越的药物中的用途
US11730706B1 (en) * 2022-07-07 2023-08-22 Antecip Bioventures Ii Llc Treatment of depression in certain patient populations
CN117783322A (zh) * 2022-12-16 2024-03-29 杭州剂泰医药科技有限责任公司 右美沙芬奎尼丁组合物的hplc分析方法
KR20250120917A (ko) 2024-02-02 2025-08-11 단국대학교 천안캠퍼스 산학협력단 덱스트로메토르판을 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학 조성물
KR20250129211A (ko) 2024-02-22 2025-08-29 단국대학교 천안캠퍼스 산학협력단 데가렐릭스를 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학적 조성물

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Also Published As

Publication number Publication date
TW201613591A (en) 2016-04-16
EP3932907A3 (en) 2022-03-30
US20190111047A1 (en) 2019-04-18
SG10201901242PA (en) 2019-03-28
JP2020019818A (ja) 2020-02-06
KR20170052684A (ko) 2017-05-12
MX2017003066A (es) 2017-09-12
IL274742A (en) 2020-07-30
JP7360409B2 (ja) 2023-10-12
SG11201701645WA (en) 2017-04-27
US20200289499A1 (en) 2020-09-17
RU2017112747A (ru) 2018-10-15
EP3932907A2 (en) 2022-01-05
EP4166141A1 (en) 2023-04-19
RU2017112747A3 (2) 2019-04-29
AU2015314710A1 (en) 2017-04-20
CN110664801A (zh) 2020-01-10
EP3193872A1 (en) 2017-07-26
JP2023105265A (ja) 2023-07-28
MX2021010696A (es) 2021-10-01
RU2020116666A (ru) 2020-07-31
EP3193872A4 (en) 2018-02-28
MX2022008181A (es) 2022-08-10
US20240082237A1 (en) 2024-03-14
JP2021080300A (ja) 2021-05-27
CN107072990A (zh) 2017-08-18
PH12017500444A1 (en) 2017-07-31
WO2016040930A1 (en) 2016-03-17
JP2017531033A (ja) 2017-10-19
TWI869633B (zh) 2025-01-11
TW202231278A (zh) 2022-08-16
AU2022283671B2 (en) 2025-03-20
IL250786A0 (en) 2017-04-30
EP3708168A2 (en) 2020-09-16
CN117427077A (zh) 2024-01-23
TW202106301A (zh) 2021-02-16
MY198587A (en) 2023-09-06
EP3708168A3 (en) 2020-12-09
AU2022283671A1 (en) 2023-02-02
AU2020289733A1 (en) 2021-01-21

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