BR9909146A - Derivados de indol apresentando uma atividade antiviral - Google Patents

Derivados de indol apresentando uma atividade antiviral

Info

Publication number
BR9909146A
BR9909146A BR9909146-1A BR9909146A BR9909146A BR 9909146 A BR9909146 A BR 9909146A BR 9909146 A BR9909146 A BR 9909146A BR 9909146 A BR9909146 A BR 9909146A
Authority
BR
Brazil
Prior art keywords
optionally substituted
hydrogen
antiviral activity
lower alkyl
indole derivatives
Prior art date
Application number
BR9909146-1A
Other languages
English (en)
Inventor
Toshio Fujishita
Tomokazu Yoshinaga
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR9909146A publication Critical patent/BR9909146A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE INDOL APRESENTANDO UMA ATIVIDADE ANTIVIRAL"<D>. Composto da fórmula: onde R¹ é hidrogênio, alquila inferior, ou aril sulfonila opcionalmente substituída, ou semelhantes, R² é hidrogênio, alquila inferior, ou aralquila opcionalmente substituída, ou semelhantes, R³, R^ 4^, R^ 5^, e R^ 6^ cada um é independentemente hidrogênio, halogênio, alquila inferior tri - halogenado, ou semelhantes, X é hidróxi ou amino opcionalmente substituído, Y é COOR (R é hidrogênio ou um resíduo éster), arila opcionalmente substituída, ou hetero arila opcionalmente substituída, tem atividade de inibição de integrase, e é útil como uma droga anti-HIV.
BR9909146-1A 1998-03-26 1999-03-26 Derivados de indol apresentando uma atividade antiviral BR9909146A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7820398 1998-03-26
PCT/JP1999/001547 WO1999050245A1 (en) 1998-03-26 1999-03-26 Indole derivatives with antiviral activity

Publications (1)

Publication Number Publication Date
BR9909146A true BR9909146A (pt) 2000-12-05

Family

ID=13655476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909146-1A BR9909146A (pt) 1998-03-26 1999-03-26 Derivados de indol apresentando uma atividade antiviral

Country Status (17)

Country Link
US (3) US6333323B1 (pt)
EP (1) EP1069111A4 (pt)
JP (1) JP3794469B2 (pt)
KR (1) KR20010041705A (pt)
CN (1) CN1142909C (pt)
AU (1) AU752005B2 (pt)
BR (1) BR9909146A (pt)
CA (1) CA2326166A1 (pt)
HU (1) HUP0103460A3 (pt)
ID (1) ID26031A (pt)
IL (1) IL137974A0 (pt)
NO (1) NO317423B1 (pt)
NZ (1) NZ506435A (pt)
PL (1) PL343249A1 (pt)
RU (1) RU2217421C2 (pt)
WO (1) WO1999050245A1 (pt)
ZA (1) ZA200004047B (pt)

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Also Published As

Publication number Publication date
PL343249A1 (en) 2001-07-30
US6506787B2 (en) 2003-01-14
NO20004787L (no) 2000-11-27
HUP0103460A3 (en) 2002-11-28
EP1069111A4 (en) 2001-06-06
CN1294580A (zh) 2001-05-09
NZ506435A (en) 2002-08-28
HUP0103460A2 (hu) 2002-01-28
EP1069111A1 (en) 2001-01-17
NO317423B1 (no) 2004-10-25
IL137974A0 (en) 2001-10-31
US6333323B1 (en) 2001-12-25
CA2326166A1 (en) 1999-10-07
WO1999050245A1 (en) 1999-10-07
NO20004787D0 (no) 2000-09-25
ZA200004047B (en) 2001-04-25
AU752005B2 (en) 2002-09-05
US6716605B2 (en) 2004-04-06
CN1142909C (zh) 2004-03-24
KR20010041705A (ko) 2001-05-25
ID26031A (id) 2000-11-16
US20020019434A1 (en) 2002-02-14
JP3794469B2 (ja) 2006-07-05
US20030181499A1 (en) 2003-09-25
RU2217421C2 (ru) 2003-11-27
AU2958199A (en) 1999-10-18

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