CA2990460C - (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate - Google Patents
(4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate Download PDFInfo
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- CA2990460C CA2990460C CA2990460A CA2990460A CA2990460C CA 2990460 C CA2990460 C CA 2990460C CA 2990460 A CA2990460 A CA 2990460A CA 2990460 A CA2990460 A CA 2990460A CA 2990460 C CA2990460 C CA 2990460C
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- Prior art keywords
- pain
- pyran
- salt
- crystalline form
- ray powder
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15175066 | 2015-07-02 | ||
| EP15175066.8 | 2015-07-02 | ||
| PCT/US2016/040728 WO2017004537A1 (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2990460A1 CA2990460A1 (en) | 2017-01-05 |
| CA2990460C true CA2990460C (en) | 2023-10-17 |
Family
ID=53502570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2990460A Active CA2990460C (en) | 2015-07-02 | 2016-07-01 | (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10213428B2 (2) |
| EP (1) | EP3317270B1 (2) |
| JP (1) | JP6917910B2 (2) |
| CN (1) | CN108026087B (2) |
| AU (1) | AU2016287584B2 (2) |
| BR (1) | BR112017028492B1 (2) |
| CA (1) | CA2990460C (2) |
| ES (1) | ES2811098T3 (2) |
| IL (1) | IL256530A (2) |
| MX (1) | MX383744B (2) |
| PL (1) | PL3317270T3 (2) |
| PT (1) | PT3317270T (2) |
| WO (1) | WO2017004537A1 (2) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| PT3317270T (pt) * | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228900A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Arylamide substituted indazoles and the use thereof as medicament |
| US20250333414A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
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| PT3317270T (pt) | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
-
2016
- 2016-07-01 PT PT168188985T patent/PT3317270T/pt unknown
- 2016-07-01 PL PL16818898T patent/PL3317270T3/pl unknown
- 2016-07-01 WO PCT/US2016/040728 patent/WO2017004537A1/en not_active Ceased
- 2016-07-01 JP JP2017568018A patent/JP6917910B2/ja not_active Expired - Fee Related
- 2016-07-01 EP EP16818898.5A patent/EP3317270B1/en active Active
- 2016-07-01 MX MX2017017177A patent/MX383744B/es unknown
- 2016-07-01 CA CA2990460A patent/CA2990460C/en active Active
- 2016-07-01 CN CN201680045214.8A patent/CN108026087B/zh active Active
- 2016-07-01 ES ES16818898T patent/ES2811098T3/es active Active
- 2016-07-01 BR BR112017028492-8A patent/BR112017028492B1/pt active IP Right Grant
- 2016-07-01 AU AU2016287584A patent/AU2016287584B2/en not_active Ceased
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2017
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2018
- 2018-12-19 US US16/224,902 patent/US10568885B2/en active Active
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- 2020-02-11 US US16/787,433 patent/US11147814B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| PT3317270T (pt) | 2020-08-24 |
| EP3317270B1 (en) | 2020-05-13 |
| ES2811098T3 (es) | 2021-03-10 |
| US11147814B2 (en) | 2021-10-19 |
| AU2016287584A1 (en) | 2018-04-19 |
| EP3317270A4 (en) | 2019-01-02 |
| BR112017028492A2 (pt) | 2018-08-28 |
| CN108026087B (zh) | 2021-06-04 |
| BR112017028492B1 (pt) | 2023-12-26 |
| EP3317270A1 (en) | 2018-05-09 |
| WO2017004537A1 (en) | 2017-01-05 |
| IL256530A (en) | 2018-02-28 |
| CA2990460A1 (en) | 2017-01-05 |
| MX2017017177A (es) | 2018-11-09 |
| JP2018524342A (ja) | 2018-08-30 |
| US10568885B2 (en) | 2020-02-25 |
| HK1254741A1 (en) | 2019-07-26 |
| CN108026087A (zh) | 2018-05-11 |
| US10213428B2 (en) | 2019-02-26 |
| US12076321B2 (en) | 2024-09-03 |
| AU2016287584B2 (en) | 2020-03-26 |
| US20200276197A1 (en) | 2020-09-03 |
| JP6917910B2 (ja) | 2021-08-11 |
| US20190262339A1 (en) | 2019-08-29 |
| MX383744B (es) | 2025-03-14 |
| US20180207157A1 (en) | 2018-07-26 |
| NZ738565A (en) | 2024-10-25 |
| US20220133723A1 (en) | 2022-05-05 |
| PL3317270T3 (pl) | 2020-11-16 |
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