IL256530A - (4–((r4, r3)–3–methoxytetrahydro–pyrene–4–ylamino)piperidin–1–yl(5–methyl–6–(((s6, r2)–6–(tolyl–p)tetrahydro h2– -pyrene-2-yl)methylamino)pyrimidine-4-yl)methanone citrate - Google Patents

(4–((r4, r3)–3–methoxytetrahydro–pyrene–4–ylamino)piperidin–1–yl(5–methyl–6–(((s6, r2)–6–(tolyl–p)tetrahydro h2– -pyrene-2-yl)methylamino)pyrimidine-4-yl)methanone citrate

Info

Publication number
IL256530A
IL256530A IL256530A IL25653017A IL256530A IL 256530 A IL256530 A IL 256530A IL 256530 A IL256530 A IL 256530A IL 25653017 A IL25653017 A IL 25653017A IL 256530 A IL256530 A IL 256530A
Authority
IL
Israel
Prior art keywords
pyran
ptolyl
methoxytetrahydro
ylamino
pyrimidin
Prior art date
Application number
IL256530A
Other languages
English (en)
Hebrew (he)
Original Assignee
Centrexion Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centrexion Therapeutics Corp filed Critical Centrexion Therapeutics Corp
Publication of IL256530A publication Critical patent/IL256530A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL256530A 2015-07-02 2017-12-24 (4–((r4, r3)–3–methoxytetrahydro–pyrene–4–ylamino)piperidin–1–yl(5–methyl–6–(((s6, r2)–6–(tolyl–p)tetrahydro h2– -pyrene-2-yl)methylamino)pyrimidine-4-yl)methanone citrate IL256530A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15175066 2015-07-02
PCT/US2016/040728 WO2017004537A1 (en) 2015-07-02 2016-07-01 (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate

Publications (1)

Publication Number Publication Date
IL256530A true IL256530A (en) 2018-02-28

Family

ID=53502570

Family Applications (1)

Application Number Title Priority Date Filing Date
IL256530A IL256530A (en) 2015-07-02 2017-12-24 (4–((r4, r3)–3–methoxytetrahydro–pyrene–4–ylamino)piperidin–1–yl(5–methyl–6–(((s6, r2)–6–(tolyl–p)tetrahydro h2– -pyrene-2-yl)methylamino)pyrimidine-4-yl)methanone citrate

Country Status (13)

Country Link
US (4) US10213428B2 (2)
EP (1) EP3317270B1 (2)
JP (1) JP6917910B2 (2)
CN (1) CN108026087B (2)
AU (1) AU2016287584B2 (2)
BR (1) BR112017028492B1 (2)
CA (1) CA2990460C (2)
ES (1) ES2811098T3 (2)
IL (1) IL256530A (2)
MX (1) MX383744B (2)
PL (1) PL3317270T3 (2)
PT (1) PT3317270T (2)
WO (1) WO2017004537A1 (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
PT3317270T (pt) * 2015-07-02 2020-08-24 Centrexion Therapeutics Corp (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona
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US20250333414A1 (en) 2024-04-30 2025-10-30 Boehringer Ingelheim International Gmbh Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228899A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Further heterocyclic compounds as sting antagonists and the use thereof as medicament
US20250333398A1 (en) 2024-04-30 2025-10-30 Boehringer Ingelheim International Gmbh Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228902A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Heterocyclic acids as sting antagonists and the use thereof as medicament

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US11147814B2 (en) 2021-10-19
AU2016287584A1 (en) 2018-04-19
EP3317270A4 (en) 2019-01-02
BR112017028492A2 (pt) 2018-08-28
CN108026087B (zh) 2021-06-04
BR112017028492B1 (pt) 2023-12-26
EP3317270A1 (en) 2018-05-09
WO2017004537A1 (en) 2017-01-05
CA2990460A1 (en) 2017-01-05
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US20190262339A1 (en) 2019-08-29
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US20180207157A1 (en) 2018-07-26
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