CA3023154C - Derive de benzazepine, procede pour le preparer, composition pharmaceutique et son utilisation - Google Patents

Derive de benzazepine, procede pour le preparer, composition pharmaceutique et son utilisation Download PDF

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CA3023154C
CA3023154C CA3023154A CA3023154A CA3023154C CA 3023154 C CA3023154 C CA 3023154C CA 3023154 A CA3023154 A CA 3023154A CA 3023154 A CA3023154 A CA 3023154A CA 3023154 C CA3023154 C CA 3023154C
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compound
alkyl
group
pharmaceutically acceptable
prodrug
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CA3023154A1 (fr
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Daxin Gao
Yuxun Wang
Shoujun Chen
Heping Yang
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Shanghai de Novo Pharmatech Co Ltd
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Shanghai de Novo Pharmatech Co Ltd
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

L'invention concerne un dérivé de benzazépine, un procédé pour le préparer, ainsi qu'une composition pharmaceutique et une utilisation de celle-ci. Le composé tel que présenté dans la formule (I) de la présente invention, et un isomère, un promédicament, un dérivé isotopique stable ou un sel pharmaceutiquement acceptable de celui-ci ont la structure suivante. Le dérivé de benzazépine de la présente invention a un bon effet de régulation sur la famille des TLR et sur la voie de signalisation associée. Il a en particulier un très bon effet de régulation sur TLR8 et peut efficacement traiter, soulager et/ou prévenir diverses maladies médiées par la famille des TLR et la voie de signalisation associée aux TLR, en particulier peut efficacement traiter, soulager et/ou prévenir diverses maladies médiées par TLR8, telles que des cancers, des maladies auto-immunes, des infections, des inflammations, des rejets de greffon, des maladies du greffon contre l'hôte, etc.
CA3023154A 2016-05-06 2017-05-04 Derive de benzazepine, procede pour le preparer, composition pharmaceutique et son utilisation Active CA3023154C (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CN201610296748 2016-05-06
CN201610296748.X 2016-05-06
CN201610589219 2016-07-25
CN201610589219.9 2016-07-25
CN201610965360 2016-11-04
CN201610965360.4 2016-11-04
CN201710020298 2017-01-12
CN201710020298.6 2017-01-12
CN201710054038.0 2017-01-24
CN201710054038 2017-01-24
PCT/CN2017/083031 WO2017190669A1 (fr) 2016-05-06 2017-05-04 Dérivé de benzazépine, procédé pour le préparer, composition pharmaceutique et son utilisation

Publications (2)

Publication Number Publication Date
CA3023154A1 CA3023154A1 (fr) 2017-11-09
CA3023154C true CA3023154C (fr) 2021-01-12

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CA3023154A Active CA3023154C (fr) 2016-05-06 2017-05-04 Derive de benzazepine, procede pour le preparer, composition pharmaceutique et son utilisation

Country Status (22)

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US (1) US10669252B2 (fr)
EP (1) EP3453707B1 (fr)
JP (1) JP6739548B2 (fr)
KR (1) KR102274557B1 (fr)
CN (1) CN107344931B (fr)
AU (1) AU2017259654B2 (fr)
CA (1) CA3023154C (fr)
CY (1) CY1126367T1 (fr)
DK (1) DK3453707T3 (fr)
ES (1) ES2907981T3 (fr)
HR (1) HRP20220577T1 (fr)
HU (1) HUE057924T2 (fr)
LT (1) LT3453707T (fr)
MX (1) MX382727B (fr)
PH (1) PH12018502336A1 (fr)
PL (1) PL3453707T3 (fr)
PT (1) PT3453707T (fr)
RS (1) RS63116B1 (fr)
SG (1) SG11201809859VA (fr)
SI (1) SI3453707T1 (fr)
SM (1) SMT202200122T1 (fr)
WO (1) WO2017190669A1 (fr)

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MX382033B (es) 2014-03-19 2025-03-13 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2017048702A1 (fr) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Formes solides de dérivés d'isoquinolinone, leur procédé de fabrication, compositions les comprenant et méthodes d'utilisation de celles-ci
JP6918838B2 (ja) 2016-05-23 2021-08-11 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 第三級アミド基を有するベンズアゼピンジカルボキサミド化合物
CN109311854B (zh) 2016-05-23 2021-08-10 豪夫迈·罗氏有限公司 具有仲酰胺官能团的苯并氮杂卓二甲酰胺化合物
JP7012668B2 (ja) 2016-06-12 2022-02-14 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物
KR20230010826A (ko) 2016-10-14 2023-01-19 프리시젼 바이오사이언시스 인코포레이티드 B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제
SG10202110182PA (en) 2017-03-15 2021-10-28 Silverback Therapeutics Inc Benzazepine compounds, conjugates, and uses thereof
US10899733B2 (en) 2017-08-23 2021-01-26 Oregon Health & Science University Inhibitors of PARPs that catalyze mono-ADP-ribosylation
WO2019084060A1 (fr) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. Conjugués et leurs procédés d'utilisation pour l'administration sélective d'agents immunomodulateurs
JP2021506827A (ja) 2017-12-15 2021-02-22 シルバーバック セラピューティックス インコーポレイテッド 肝炎の治療用の抗体コンストラクト−薬物コンジュゲート
EP3728283B1 (fr) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
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