CA3033239A1 - Inhibiteurs spiro bicycliques de l'interaction menine-mll - Google Patents

Inhibiteurs spiro bicycliques de l'interaction menine-mll Download PDF

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Publication number
CA3033239A1
CA3033239A1 CA3033239A CA3033239A CA3033239A1 CA 3033239 A1 CA3033239 A1 CA 3033239A1 CA 3033239 A CA3033239 A CA 3033239A CA 3033239 A CA3033239 A CA 3033239A CA 3033239 A1 CA3033239 A1 CA 3033239A1
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Canada
Prior art keywords
group
optionally substituted
4alkyl
hydrogen
compound
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Pending
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CA3033239A
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English (en)
Inventor
Patrick Rene Angibaud
Vineet PANDE
Barbara HERKERT
Daniel Jason Krosky
Olivier Alexis Georges Querolle
Isabelle Noelle Constance Pilatte
Aaron Nathaniel PATRICK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA3033239A1 publication Critical patent/CA3033239A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des agents pharmaceutiques utiles pour la thérapie et/ou la prophylaxie chez un mammifère, et en particulier des composés spiro bicycliques, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs d'interactions ménine/protéine MLL/protéine, utiles pour le traitement de maladies telles que le cancer, le syndrome myélodysplasique (MDS) et le diabète.
CA3033239A 2016-09-14 2017-09-13 Inhibiteurs spiro bicycliques de l'interaction menine-mll Pending CA3033239A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662394295P 2016-09-14 2016-09-14
US62/394,295 2016-09-14
EP16192431 2016-10-05
EP16192431.1 2016-10-05
PCT/EP2017/073004 WO2018050686A1 (fr) 2016-09-14 2017-09-13 Inhibiteurs spiro bicycliques de l'interaction ménine-mll

Publications (1)

Publication Number Publication Date
CA3033239A1 true CA3033239A1 (fr) 2018-03-22

Family

ID=57083210

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3033239A Pending CA3033239A1 (fr) 2016-09-14 2017-09-13 Inhibiteurs spiro bicycliques de l'interaction menine-mll

Country Status (4)

Country Link
CA (1) CA3033239A1 (fr)
EA (1) EA201990699A1 (fr)
TW (1) TWI738864B (fr)
WO (1) WO2018050686A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112771055A (zh) * 2018-08-08 2021-05-07 大日本住友制药株式会社 光学活性桥接哌啶衍生物

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040330A1 (fr) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Composés de thiénopyrimidine et de thiénopyridine et leurs procédés d'utilisation
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
HK1246593A1 (zh) 2015-06-04 2018-09-14 Kura Oncology, Inc. 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物
EP3429591B1 (fr) 2016-03-16 2023-03-15 Kura Oncology, Inc. Composés thiéno[2,3-d]pyrimidiniques substitués en tant qu'inhibiteurs de ménine-mll et méthodes d'utilisation
MX387806B (es) 2016-03-16 2025-03-19 Kura Oncology Inc Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso
ES2872003T3 (es) 2016-09-14 2021-11-02 Janssen Pharmaceutica Nv Inhibidores espirobicíclicos de la interacción de menina-MLL
US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
EP3512858B1 (fr) 2016-09-14 2023-11-08 Janssen Pharmaceutica NV Inhibiteur bicyclique fusionné d'interaction menin-mll
KR102513564B1 (ko) 2016-12-15 2023-03-22 얀센 파마슈티카 엔.브이. 메닌-mll 상호작용의 아제판 억제제
EP3601249A4 (fr) 2017-03-24 2020-12-16 Kura Oncology, Inc. Méthodes de traitement d'hémopathies malignes et du sarcome d'ewing
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
TW201920170A (zh) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
JP7307729B2 (ja) * 2017-12-20 2023-07-12 ヤンセン ファーマシューティカ エヌ．ベー． メニン－ｍｌｌ相互作用のエキソ－アザスピロ阻害剤
US11396517B1 (en) 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction
CN112105621B (zh) 2018-03-30 2024-02-20 住友制药株式会社 光学活性桥型环状仲胺衍生物
US10815241B2 (en) 2018-08-27 2020-10-27 Sumitomo Dainippon Pharma Co., Ltd. Optically active azabicyclo ring derivative
JP6671574B1 (ja) 2018-08-27 2020-03-25 大日本住友製薬株式会社 光学活性なアザビシクロ環誘導体
MX2021006696A (es) 2018-12-06 2021-07-07 Daiichi Sankyo Co Ltd Derivado de cicloalcano-1,3-diamina.
JP7618567B2 (ja) * 2019-09-27 2025-01-21 住友ファーマ株式会社 架橋型光学活性２級アミン誘導体
TWI878414B (zh) 2019-12-19 2025-04-01 比利時商健生藥品公司 經取代之直鏈螺環接衍生物
WO2022237626A1 (fr) 2021-05-08 2022-11-17 Janssen Pharmaceutica Nv Dérivés spiro substitués
AU2022275192A1 (en) 2021-05-08 2024-01-04 Janssen Pharmaceutica Nv Substituted spiro derivatives
IL308862A (en) 2021-06-01 2024-01-01 Janssen Pharmaceutica Nv Altered phenyl-1H-pyrrolo[3,2-c]pyridine histories
BR112023025436A2 (pt) 2021-06-03 2024-02-27 Janssen Pharmaceutica Nv Piridazinas ou 1,2,4-triazinas substituídas por aminas espirocíclicas
PH12023553300A1 (en) 2021-06-17 2024-04-08 Janssen Pharmaceutica Nv (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cancer
US20250388592A1 (en) * 2022-08-11 2025-12-25 Remynd N.V. (aza)spiroheptane derivatives for the treatment of neurodegenerative disorders
WO2024110649A1 (fr) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 et d'inhibiteurs de ménine pour le traitement du cancer
AR132185A1 (es) 2023-03-24 2025-06-04 Acerta Pharma Bv COMPUESTOS DE 1-H-PIRROLO[2,3-c]PIRIDINA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993552B2 (en) 2009-09-04 2015-03-31 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
US9216993B2 (en) 2013-03-13 2015-12-22 The Regents Of The University Of Michigan Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
CN105732636B (zh) * 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
CN108779116A (zh) 2015-12-22 2018-11-09 生命医药公司 多发性内分泌瘤蛋白-mll相互作用的抑制剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112771055A (zh) * 2018-08-08 2021-05-07 大日本住友制药株式会社 光学活性桥接哌啶衍生物
CN112771055B (zh) * 2018-08-08 2023-10-20 住友制药株式会社 光学活性桥接哌啶衍生物

Also Published As

Publication number Publication date
TWI738864B (zh) 2021-09-11
TW201823250A (zh) 2018-07-01
WO2018050686A1 (fr) 2018-03-22
EA201990699A1 (ru) 2019-09-30

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