CA3049739A1 - Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5 - Google Patents

Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5 Download PDF

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Publication number
CA3049739A1
CA3049739A1 CA3049739A CA3049739A CA3049739A1 CA 3049739 A1 CA3049739 A1 CA 3049739A1 CA 3049739 A CA3049739 A CA 3049739A CA 3049739 A CA3049739 A CA 3049739A CA 3049739 A1 CA3049739 A1 CA 3049739A1
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Prior art keywords
prmt5
cancer
cell
alteration
mmol
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CA3049739A
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Dirk Brehmer
Lijs Beke
Dana Suzanne Gaffney
Christopher H Moy
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CA3049739A1 publication Critical patent/CA3049739A1/fr
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
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  • Primary Health Care (AREA)
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  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une méthode d'identification d'un patient qui est susceptible de répondre à un traitement avec un inhibiteur de la protéine arginine N-méthyltransférase 5 (PRMT5) comprenant : l'évaluation dans un échantillon biologique provenant du patient de la présence d'une modification d'épissage, la présence de ladite modification indiquant une probabilité plus élevée pour ledit patient d'être sensible au traitement avec ledit inhibiteur de PRMT5 qu'en l'absence de ladite mutation ou modification.
CA3049739A 2017-02-27 2018-02-26 Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5 Pending CA3049739A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762464006P 2017-02-27 2017-02-27
US62/464006 2017-02-27
PCT/EP2018/054644 WO2018154104A1 (fr) 2017-02-27 2018-02-26 Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles à un traitement avec un inhibiteur de prmt5

Publications (1)

Publication Number Publication Date
CA3049739A1 true CA3049739A1 (fr) 2018-08-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA3049739A Pending CA3049739A1 (fr) 2017-02-27 2018-02-26 Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5

Country Status (23)

Country Link
US (2) US11279970B2 (fr)
EP (1) EP3585904B1 (fr)
JP (1) JP7225106B2 (fr)
KR (1) KR102573149B1 (fr)
CN (1) CN110382707A (fr)
AU (1) AU2018225312B2 (fr)
BR (1) BR112019017466A2 (fr)
CA (1) CA3049739A1 (fr)
CL (1) CL2019002438A1 (fr)
CO (1) CO2019008390A2 (fr)
EA (1) EA201992026A1 (fr)
ES (1) ES2971035T3 (fr)
IL (1) IL268842B2 (fr)
JO (1) JOP20190199B1 (fr)
MA (1) MA47594A (fr)
MX (1) MX2019010150A (fr)
MY (1) MY195860A (fr)
PE (1) PE20191359A1 (fr)
PH (1) PH12019501942A1 (fr)
SG (1) SG11201907607VA (fr)
TN (1) TN2019000212A1 (fr)
UA (1) UA127679C2 (fr)
WO (1) WO2018154104A1 (fr)

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CA3049739A1 (fr) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5
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KR102531344B1 (ko) 2016-10-03 2023-05-10 얀센 파마슈티카 엔.브이. Prmt5 억제제로서 사용하기 위한 신규의 모노사이클릭 및 바이사이클릭 고리 시스템 치환된 카르바뉴클레오시드 유사체
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CA3049739A1 (fr) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Utilisation de biomarqueurs dans l'identification de patients atteints d'un cancer sensibles a un traitement avec un inhibiteur de prmt5
JP7352544B2 (ja) 2017-12-08 2023-09-28 ヤンセン ファーマシューティカ エヌ．ベー． 新規なスピロ二環式類似体

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AU2018225312A1 (en) 2019-07-25
ES2971035T3 (es) 2024-06-03
CL2019002438A1 (es) 2019-11-29
MX2019010150A (es) 2019-10-21
SG11201907607VA (en) 2019-09-27
EP3585904A1 (fr) 2020-01-01
PH12019501942A1 (en) 2020-06-29
US11279970B2 (en) 2022-03-22
TN2019000212A1 (en) 2021-01-07
JOP20190199A1 (ar) 2019-08-27
EP3585904B1 (fr) 2023-11-29
EA201992026A1 (ru) 2020-01-24
IL268842A (en) 2019-10-31
US20200010881A1 (en) 2020-01-09
JP7225106B2 (ja) 2023-02-20
MY195860A (en) 2023-02-24
PE20191359A1 (es) 2019-10-01
US11999993B2 (en) 2024-06-04
US20220205026A1 (en) 2022-06-30
WO2018154104A1 (fr) 2018-08-30
KR102573149B1 (ko) 2023-08-30
UA127679C2 (uk) 2023-11-29
JP2020508048A (ja) 2020-03-19
CO2019008390A2 (es) 2019-08-20
IL268842B1 (en) 2024-05-01
KR20190122677A (ko) 2019-10-30
MA47594A (fr) 2020-01-01
BR112019017466A2 (pt) 2020-03-31
CN110382707A (zh) 2019-10-25
EP3585904C0 (fr) 2023-11-29
JOP20190199B1 (ar) 2023-09-17
IL268842B2 (en) 2024-09-01
AU2018225312B2 (en) 2024-02-08

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