CA3093886C - Dinucleotides 2'3'-cycliques - Google Patents

Dinucleotides 2'3'-cycliques

Info

Publication number
CA3093886C
CA3093886C CA3093886A CA3093886A CA3093886C CA 3093886 C CA3093886 C CA 3093886C CA 3093886 A CA3093886 A CA 3093886A CA 3093886 A CA3093886 A CA 3093886A CA 3093886 C CA3093886 C CA 3093886C
Authority
CA
Canada
Prior art keywords
compound
acceptable salt
inhibitors
pharmaceutically acceptable
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3093886A
Other languages
English (en)
Other versions
CA3093886A1 (fr
Inventor
Gabriel Birkus
Ondrej Pav
Ivan Rosenberg
Ondrej Simak
Original Assignee
Institute of Organic Chemistry and Biochemistry of ASCR vvi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Organic Chemistry and Biochemistry of ASCR vvi filed Critical Institute of Organic Chemistry and Biochemistry of ASCR vvi
Priority claimed from PCT/IB2019/052777 external-priority patent/WO2019193542A1/fr
Publication of CA3093886A1 publication Critical patent/CA3093886A1/fr
Application granted granted Critical
Publication of CA3093886C publication Critical patent/CA3093886C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne des dinucléotides 2'3'-cycliques modifiés par une liaison 2'- ou 3'-phosphonoalkyle et leurs dérivés, qui peuvent moduler l'activité de la protéine adaptatrice (IA) de STING ou un composé de formule (1B) ou un sel pharmaceutiquement acceptable de celui-ci, L1 étant -O- ou -K-C(R6R7)- ; L2 étant -K-C(R6R7)-.
CA3093886A 2018-04-06 2019-04-04 Dinucleotides 2'3'-cycliques Active CA3093886C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862654054P 2018-04-06 2018-04-06
US62/654,054 2018-04-06
US201862737205P 2018-09-27 2018-09-27
US62/737,205 2018-09-27
PCT/IB2019/052777 WO2019193542A1 (fr) 2018-04-06 2019-04-04 Dinucléotides 2'3'-cycliques

Publications (2)

Publication Number Publication Date
CA3093886A1 CA3093886A1 (fr) 2019-10-10
CA3093886C true CA3093886C (fr) 2026-02-10

Family

ID=

Similar Documents

Publication Publication Date Title
AU2018392212B2 (en) 2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
US10966999B2 (en) 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
WO2019211799A1 (fr) Analogue de dinucléotide 2'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle
WO2019123338A1 (fr) Dinucléotides 2'2' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
AU2019247904B2 (en) 2'3'-cyclic dinucleotides
AU2020231201B2 (en) 2'3'-cyclic dinucleotides and prodrugs thereof
TWI833744B (zh) 3'3'-環二核苷酸
CA3129011C (fr) Dinucleotides 3'3'-cycliques et leurs promedicaments
EP3935065A1 (fr) Analogue du dinucléotide 3'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle utilisé en tant que modulateur de sting
WO2019193533A1 (fr) Dinucléotides 2'2'-cycliques
CA3093886C (fr) Dinucleotides 2'3'-cycliques
CA3093888C (fr) Dinucleotides 3'3'-cycliques