CA3093888C - Dinucleotides 3'3'-cycliques - Google Patents

Dinucleotides 3'3'-cycliques

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Publication number
CA3093888C
CA3093888C CA3093888A CA3093888A CA3093888C CA 3093888 C CA3093888 C CA 3093888C CA 3093888 A CA3093888 A CA 3093888A CA 3093888 A CA3093888 A CA 3093888A CA 3093888 C CA3093888 C CA 3093888C
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CA
Canada
Prior art keywords
compound
inhibitors
acceptable salt
pharmaceutically acceptable
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3093888A
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English (en)
Other versions
CA3093888A1 (fr
Inventor
Gabriel Birkus
Ondrej Pav
Ivan Rosenberg
Ondrej Simak
Original Assignee
Institute of Organic Chemistry and Biochemistry of ASCR vvi
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Publication date
Application filed by Institute of Organic Chemistry and Biochemistry of ASCR vvi filed Critical Institute of Organic Chemistry and Biochemistry of ASCR vvi
Priority claimed from PCT/IB2019/052778 external-priority patent/WO2019193543A1/fr
Publication of CA3093888A1 publication Critical patent/CA3093888A1/fr
Application granted granted Critical
Publication of CA3093888C publication Critical patent/CA3093888C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne des dinucléotides 3'3'-cycliques modifiés par une liaison 3'-phosphonoalkyle et leurs dérivés, qui peuvent moduler l'activité de la protéine adaptatrice de STING (I) ou un sel pharmaceutiquement acceptable de ceux-ci, L1 étant -O- ou -K-C(R6R7)- ; L2 étant -K-C(R6R7)-.
CA3093888A 2018-04-06 2019-04-04 Dinucleotides 3'3'-cycliques Active CA3093888C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862654058P 2018-04-06 2018-04-06
US62/654,058 2018-04-06
PCT/IB2019/052778 WO2019193543A1 (fr) 2018-04-06 2019-04-04 Dinucléotides 3'3'-cycliques

Publications (2)

Publication Number Publication Date
CA3093888A1 CA3093888A1 (fr) 2019-10-10
CA3093888C true CA3093888C (fr) 2026-02-03

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