CA3094205A1 - Glycosides de steviol de haute purete - Google Patents

Glycosides de steviol de haute purete Download PDF

Info

Publication number
CA3094205A1
CA3094205A1 CA3094205A CA3094205A CA3094205A1 CA 3094205 A1 CA3094205 A1 CA 3094205A1 CA 3094205 A CA3094205 A CA 3094205A CA 3094205 A CA3094205 A CA 3094205A CA 3094205 A1 CA3094205 A1 CA 3094205A1
Authority
CA
Canada
Prior art keywords
rebaudioside
stevioside
udp
amino
glucosyltransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3094205A
Other languages
English (en)
Inventor
Avetik Markosyan
Saravanan A/l RAMANDACH
Mohamad AFZAAL BIN HASIM
Khairul NIZAM BIN NAWI
Siew Yin CHOW
Siddhartha Purkayastha
Marcia Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PureCircle USA Inc
Original Assignee
PureCircle USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2018/026920 external-priority patent/WO2019177634A1/fr
Application filed by PureCircle USA Inc filed Critical PureCircle USA Inc
Publication of CA3094205A1 publication Critical patent/CA3094205A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/36—Terpene glycosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des procédés d'utilisation de rébaudioside AM hautement purifié. Les procédés comprennent l'utilisation de préparations enzymatiques et de micro-organismes recombinants pour convertir diverses compositions de départ en glycosides de stéviol cibles. Les rébaudiosides AM hautement purifiés sont utiles en tant qu'exhausteur de goût, renforçateur de goût sucré et suppresseur de mousse dans des compositions comestibles et masticables comme des boissons, des confiseries, des produits de boulangerie, des biscuits et des gommes à mâcher.
CA3094205A 2018-03-16 2019-03-15 Glycosides de steviol de haute purete Pending CA3094205A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862644065P 2018-03-16 2018-03-16
US62/644,065 2018-03-16
US201862644407P 2018-03-17 2018-03-17
US62/644,407 2018-03-17
USPCT/US2018/026920 2018-04-10
PCT/US2018/026920 WO2019177634A1 (fr) 2018-03-16 2018-04-10 Glycosides de stéviol de haute pureté
US201962802111P 2019-02-06 2019-02-06
US62/802,111 2019-02-06
PCT/US2019/022581 WO2019178541A1 (fr) 2018-03-16 2019-03-15 Glycosides de stéviol de haute pureté

Publications (1)

Publication Number Publication Date
CA3094205A1 true CA3094205A1 (fr) 2019-09-19

Family

ID=67908464

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3094205A Pending CA3094205A1 (fr) 2018-03-16 2019-03-15 Glycosides de steviol de haute purete

Country Status (8)

Country Link
EP (1) EP3765472A4 (fr)
JP (2) JP7432533B2 (fr)
KR (1) KR20200132940A (fr)
CN (1) CN112513059A (fr)
AU (2) AU2019236279B2 (fr)
CA (1) CA3094205A1 (fr)
MX (1) MX2020009635A (fr)
WO (1) WO2019178541A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024010442A1 (fr) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd Glycosides de stéviol de haute pureté

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220232860A1 (en) * 2019-05-17 2022-07-28 Purecircle Usa Inc. Stevia flavor compositions
WO2021226417A1 (fr) * 2020-05-07 2021-11-11 The Coca-Cola Company Boissons comprenant du rébaudioside am et du rébaudioside m à saveur améliorée
CN114045273B (zh) * 2021-11-15 2022-07-22 四川大学 糖基转移酶OsUGT91C1突变体及其应用
CN114315926B (zh) * 2022-01-04 2024-02-06 东台市浩瑞生物科技有限公司 一种多次高温裂解法生产甜菊双糖苷的工艺方法
CN117106000A (zh) * 2023-07-17 2023-11-24 华南理工大学 一种甜菊糖苷聚集体及其制备方法和应用
CN117752583B (zh) * 2023-12-26 2025-12-19 江苏雪豹日化有限公司 一种无水漱口水及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5307730B2 (ja) * 2007-01-22 2013-10-02 カーギル・インコーポレイテッド 溶媒／貧溶媒晶析を用いる精製レバウディオサイドａ組成物の製法
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
EP3215629B1 (fr) * 2014-11-05 2024-08-07 Manus Bio Inc. Production microbienne de glycosides de stéviol
US10058112B2 (en) * 2014-11-21 2018-08-28 Eco Sweeteners Llc Sweetener composition including enzymatically processed stevia and method of manufacturing
JP6793957B2 (ja) * 2015-04-14 2020-12-02 コナゲン インコーポレイテッド 改変された全細胞触媒を用いたノンカロリー甘味料の生成
MX2018006599A (es) * 2015-11-30 2018-09-21 Purecircle Sdn Bhd Proceso para producir glicosidos de esteviol de alta pureza.
CN110191643B (zh) * 2016-10-14 2023-06-06 科纳根公司 甜菊醇糖苷的生物合成生产及其工艺
AU2017345605B2 (en) * 2016-10-20 2022-04-14 The Coca-Cola Company Diterpene glycosides isolated from Stevia, compositions and methods
MX2019010537A (es) * 2017-03-06 2019-11-21 Conagen Inc Produccion biosintetica del rebaudiosido d4 de glucosido de esteviol a partir del rebaudiosido e.
MX2019015404A (es) * 2017-06-30 2020-07-20 Conagen Inc Hidrólisis de glucósidos de esteviol por beta-glucosidasa.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024010442A1 (fr) * 2022-07-07 2024-01-11 Purecircle Sdn Bhd Glycosides de stéviol de haute pureté

Also Published As

Publication number Publication date
BR112020018972A2 (pt) 2021-01-05
EP3765472A4 (fr) 2022-01-19
CN112513059A (zh) 2021-03-16
AU2019236279B2 (en) 2023-11-23
JP7432533B2 (ja) 2024-02-16
KR20200132940A (ko) 2020-11-25
JP2021518163A (ja) 2021-08-02
AU2024201079A1 (en) 2024-03-07
MX2020009635A (es) 2021-02-16
AU2024201079B2 (en) 2026-04-09
JP2024033006A (ja) 2024-03-12
WO2019178541A1 (fr) 2019-09-19
AU2019236279A1 (en) 2020-10-08
EP3765472A1 (fr) 2021-01-20

Similar Documents

Publication Publication Date Title
US20250263768A1 (en) High-purity steviol glycosides
AU2024201079B2 (en) High-purity steviol glycosides
AU2019282411B2 (en) High-purity steviol glycosides
US20220017557A1 (en) High-purity steviol glycosides
US20220380824A1 (en) High-purity steviol glycosides
AU2019236227B2 (en) High-purity steviol glycosides
WO2019178471A1 (fr) Glycosides de stéviol de haute pureté
US20210002318A1 (en) High-purity steviol glycosides
US20240360489A1 (en) High-purity steviol glycosides
RU2848318C2 (ru) Стевиолгликозиды высокой чистоты
KR102955704B1 (ko) 고순도 스테비올 글리코사이드
BR112020018972B1 (pt) Método para intensificar o sabor em um produto consumível

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20240308

D16 Fast track examination requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D16-D106 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION REQUESTED - PARAGRAPH 84(1)(A) OF THE PATENT RULES

Effective date: 20241028

D17 Fast track examination accepted

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D17-D110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION DETERMINED COMPLIANT - PARAGRAPH 84(1)(A) OF THE PATENT RULES

Effective date: 20241028

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241028

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20241101

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D120 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: VOLUNTARY SUBMISSION OF PRIOR ART RECEIVED

Effective date: 20241121

D16 Fast track examination requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D16-D108 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION REQUESTED - PPH

Effective date: 20241121

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT

Effective date: 20241121

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241218

D00 Search and/or examination requested or commenced

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D00-D123 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIOR ART DISCLOSURE DETERMINED COMPLIANT

Effective date: 20241220

D16 Fast track examination requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D16-D116 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION REFUSED - PPH

Effective date: 20241220

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20241220

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20241220

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241220

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20241220

D17 Fast track examination accepted

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D17-D112 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ADVANCED EXAMINATION DETERMINED COMPLIANT - PPH

Effective date: 20250210

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250210

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250210

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250307

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250307

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250307

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20250411

B12 Application deemed to be withdrawn, abandoned or lapsed

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION

Effective date: 20250811